MX9706429A - Variantes de dnasa i humana. - Google Patents

Variantes de dnasa i humana.

Info

Publication number
MX9706429A
MX9706429A MX9706429A MX9706429A MX9706429A MX 9706429 A MX9706429 A MX 9706429A MX 9706429 A MX9706429 A MX 9706429A MX 9706429 A MX9706429 A MX 9706429A MX 9706429 A MX9706429 A MX 9706429A
Authority
MX
Mexico
Prior art keywords
variants
human dnase
actin
relates
resistant
Prior art date
Application number
MX9706429A
Other languages
English (en)
Inventor
Robert A Lazarus
Steven Shak
Jana S Ulmer
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1995/002366 external-priority patent/WO1996026278A1/en
Application filed by Genentech Inc filed Critical Genentech Inc
Priority claimed from PCT/US1996/002421 external-priority patent/WO1996026279A1/en
Publication of MX9706429A publication Critical patent/MX9706429A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases RNAses, DNAses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente invencion se relaciona con la secuencia de aminoácidos de variantes de DNasa I humana que tienen afinidad de union reducida por actina. La invencion proporciona secuencias de ácido nucleico que codifica para tales variantes resistentes a actina, por lo que permiten la produccion de estas variantes en cantidades suficientes para uso clínico. La invencion también es relaciona con composiciones farmacéuticas y usos terapéuticos de las variantes resistentes a actina de la DNasa I humana.
MX9706429A 1995-02-24 1996-02-21 Variantes de dnasa i humana. MX9706429A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/US1995/002366 WO1996026278A1 (en) 1995-02-24 1995-02-24 HUMAN DNase I VARIANTS
US54052795A 1995-10-10 1995-10-10
PCT/US1996/002421 WO1996026279A1 (en) 1995-02-24 1996-02-21 Human dnase i variants

Publications (1)

Publication Number Publication Date
MX9706429A true MX9706429A (es) 1997-11-29

Family

ID=24155835

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9706429A MX9706429A (es) 1995-02-24 1996-02-21 Variantes de dnasa i humana.

Country Status (5)

Country Link
JP (3) JP4624380B2 (es)
BG (1) BG64423B1 (es)
CZ (1) CZ297463B6 (es)
MX (1) MX9706429A (es)
PT (1) PT854927E (es)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990007572A1 (en) * 1988-12-23 1990-07-12 Genentech, Inc. HUMAN DNase
US5464817A (en) * 1990-04-11 1995-11-07 Brigham And Women's Hospital Method for reducing the viscosity of pathological mucoid airway contents in the respiratory tract comprising administering actin-binding compounds with or without DNASE I

Also Published As

Publication number Publication date
BG64423B1 (bg) 2005-01-31
CZ267897A3 (cs) 1998-01-14
JP2007312781A (ja) 2007-12-06
JP2010088452A (ja) 2010-04-22
JP2010057516A (ja) 2010-03-18
PT854927E (pt) 2008-09-08
CZ297463B6 (cs) 2006-12-13
BG101847A (en) 1998-07-31
JP4624380B2 (ja) 2011-02-02

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Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees