MX9705612A - Induccion dirigida por linaje de la diferenciacion de celulas mesenquimatosas humanas de origen. - Google Patents

Induccion dirigida por linaje de la diferenciacion de celulas mesenquimatosas humanas de origen.

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Publication number
MX9705612A
MX9705612A MX9705612A MX9705612A MX9705612A MX 9705612 A MX9705612 A MX 9705612A MX 9705612 A MX9705612 A MX 9705612A MX 9705612 A MX9705612 A MX 9705612A MX 9705612 A MX9705612 A MX 9705612A
Authority
MX
Mexico
Prior art keywords
lineage
mesenchymal stem
stem cells
human mesenchymal
induction
Prior art date
Application number
MX9705612A
Other languages
English (en)
Other versions
MXPA97005612A (es
Inventor
Scott P Bruder
Arnold I Caplan
Stephen E Haynesworth
Original Assignee
Univ Case Western Reserve
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Case Western Reserve filed Critical Univ Case Western Reserve
Publication of MX9705612A publication Critical patent/MX9705612A/es
Publication of MXPA97005612A publication Critical patent/MXPA97005612A/es

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/203—Retinoic acids ; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
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    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
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    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1841—Transforming growth factor [TGF]
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    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
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    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/00—Medicinal preparations containing peptides
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0654—Osteocytes, Osteoblasts, Odontocytes; Bones, Teeth
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0655—Chondrocytes; Cartilage
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
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Abstract

Se presentan métodos para la induccion dirigida por linaje in vitro o ek vivo de células mesenquimatosas de origen humanas expandidas por cultivo, aisladas, que comprenden la puesta en contacto de la células mesenquimatosas de origen con un factor bioactivo efectivo para inducir la diferenciacion de las mismas en un linaje de eleccion así como composiciones que incluyen células mesenquimatosas de origen humanas expandidas por cultivo aisladas y factores bioactivos efectivos para inducir la induccion por linaje dirigida. Se presenta además el método que incluye también la introduccion de tales células mesenquimatosas de origen inducidas por linaje expandidas por cultivo en un huéspeda partir del cual han sido originadas con el proposito de regeneracion o bien reparacion de tejido mesenquimatoso.
MXPA/A/1997/005612A 1995-01-24 1997-07-24 Induccion dirigida por linaje de la diferenciacion de celulas mesenquimatosas humanas de origen MXPA97005612A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08377461 1995-01-24
US08/377,461 US5736396A (en) 1995-01-24 1995-01-24 Lineage-directed induction of human mesenchymal stem cell differentiation

Publications (2)

Publication Number Publication Date
MX9705612A true MX9705612A (es) 1998-10-31
MXPA97005612A MXPA97005612A (es) 1999-01-11

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Also Published As

Publication number Publication date
PT805853E (pt) 2007-06-27
JP2010012331A (ja) 2010-01-21
ES2285710T3 (es) 2007-11-16
US5942225A (en) 1999-08-24
CA2211120C (en) 2001-04-03
EP0805853A4 (en) 1999-12-22
CA2211120A1 (en) 1996-08-01
JP4454697B2 (ja) 2010-04-21
WO1996023059A1 (en) 1996-08-01
ATE357508T1 (de) 2007-04-15
AU719098B2 (en) 2000-05-04
EP0805853A1 (en) 1997-11-12
EP1717310A1 (en) 2006-11-02
JPH10512756A (ja) 1998-12-08
US5736396A (en) 1998-04-07
DE69636979T2 (de) 2007-12-20
DE69636979D1 (de) 2007-05-03
AU4746996A (en) 1996-08-14
JP5173982B2 (ja) 2013-04-03
EP0805853B1 (en) 2007-03-21
DK0805853T3 (da) 2007-07-23

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