MX9703074A - Inhibidores de sintesis de apoliproteina-b. - Google Patents
Inhibidores de sintesis de apoliproteina-b.Info
- Publication number
- MX9703074A MX9703074A MX9703074A MX9703074A MX9703074A MX 9703074 A MX9703074 A MX 9703074A MX 9703074 A MX9703074 A MX 9703074A MX 9703074 A MX9703074 A MX 9703074A MX 9703074 A MX9703074 A MX 9703074A
- Authority
- MX
- Mexico
- Prior art keywords
- hydrogen
- halo
- formula
- apolipoprotein
- synthesis inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Abstract
La presente invencion provee compuestos novedosos de formula (I): (Ver Formula); los N-oxidos, las formas esteroquímicamente isoméricas de los mismos y la salácida de adicion farmacéuticamente aceptable de los mismos, en los que A y B tomados juntos forman un radical bivalente de formula: -N=CH- (a) -CH=N- (b), -CH2-CH2- (c), CH=CH- (d), -C(=0)-CH2- (e) Y -CH2-C(=0)- (f); R1 es hidrogeno, alquilo de C1-6 o halo; R2 es hidrogeno o halo; R2 es hidrogeno; alquilo de C1-8, cicloalquilo de C3-6 o alquilo de C1-8 sustituidos con hidroxi, oxo, cicloalquilo o arilo de C3-6; Hst es un anillo heterociclico opcionalmente substituido de cinco o seis miembros; se describe el uso como medicina, especialmente como un agente disminusor de lipidos, así como composiciones farmacéuticas y procedimientos para preparar compuestos y composiciones.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP94203120 | 1994-10-27 | ||
| EP94203120.4 | 1994-10-27 | ||
| US08/455,304 US5521186A (en) | 1994-10-27 | 1995-05-31 | Apolipoprotein-β synthesis inhibitors |
| US08455304 | 1995-05-31 | ||
| PCT/EP1995/004111 WO1996013499A1 (en) | 1994-10-27 | 1995-10-19 | Apolipoprotein-b synthesis inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX9703074A true MX9703074A (es) | 1997-07-31 |
| MXPA97003074A MXPA97003074A (es) | 1997-12-01 |
Family
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