MX9703017A - Inmunizacion oral con plantas transgenicas. - Google Patents

Inmunizacion oral con plantas transgenicas.

Info

Publication number
MX9703017A
MX9703017A MX9703017A MX9703017A MX9703017A MX 9703017 A MX9703017 A MX 9703017A MX 9703017 A MX9703017 A MX 9703017A MX 9703017 A MX9703017 A MX 9703017A MX 9703017 A MX9703017 A MX 9703017A
Authority
MX
Mexico
Prior art keywords
plants
plant
transgenic
animals
transgenic plants
Prior art date
Application number
MX9703017A
Other languages
English (en)
Inventor
Charles J Arntzen
Hugh S Mason
Tariq A Haq
John D Clements
Original Assignee
Texas A & M Univ Sys
Univ Tulane
Educational Fund
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Texas A & M Univ Sys, Univ Tulane, Educational Fund filed Critical Texas A & M Univ Sys
Publication of MX9703017A publication Critical patent/MX9703017A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/16011—Caliciviridae
    • C12N2770/16022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Cosmetics (AREA)

Abstract

Las vacunas orales y los auxiliares de vacuna orales de la presente invencion se producen en plantas transgénicas, y luego se administran a través del consumo de la planta transgénica. Se construyen secuencias de ADN que codifican tanto naturalmente como sintéticamente la expresion de agentes inmunogénicos que son capaces de provocar una respuesta inmune en animales cuando se dan como alimento en plantas comestibles, tejidos de plantas, o materiales derivados de plantas, y se transforman plantas para una expresion estable o transitoria en células de plantas. La presente invencion proporciona el primer método funcional conocido para inmunizar animales por medio de plantas transgénicas, en donde las plantas expresan antígenos bacterianos que actuan tanto como inmunogenos como auxiliares, cuando se da como alimento el material de planta transgénica que expresa los antígenos a animales.
MX9703017A 1994-10-24 1995-10-24 Inmunizacion oral con plantas transgenicas. MX9703017A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32871694A 1994-10-24 1994-10-24
PCT/US1995/013376 WO1996012801A1 (en) 1994-10-24 1995-10-24 Oral immunization with transgenic plants

Publications (1)

Publication Number Publication Date
MX9703017A true MX9703017A (es) 1997-10-31

Family

ID=23282114

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9703017A MX9703017A (es) 1994-10-24 1995-10-24 Inmunizacion oral con plantas transgenicas.

Country Status (11)

Country Link
US (1) US6194560B1 (es)
EP (1) EP0793717B1 (es)
JP (1) JPH10507916A (es)
AT (1) ATE287947T1 (es)
AU (1) AU691707B2 (es)
CA (1) CA2203679C (es)
DE (1) DE69533964T2 (es)
ES (1) ES2235176T3 (es)
MX (1) MX9703017A (es)
NZ (1) NZ297142A (es)
WO (1) WO1996012801A1 (es)

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US5612487A (en) * 1991-08-26 1997-03-18 Edible Vaccines, Inc. Anti-viral vaccines expressed in plants
US5484719A (en) 1991-08-26 1996-01-16 Edible Vaccines, Inc. Vaccines produced and administered through edible plants
US6034298A (en) * 1991-08-26 2000-03-07 Prodigene, Inc. Vaccines expressed in plants
AU6976296A (en) * 1995-09-15 1997-04-01 John A Howard Expression cassettes and methods for delivery of animal vaccines
WO1997040161A1 (en) 1996-04-19 1997-10-30 Henry M. Jackson Foundation For The Advancement Of Military Medecine Histidine-tagged intimin and methods of using intimin to stimulate an immune response and as an antigen carrier with targeting capability
JP2000510332A (ja) 1996-04-19 2000-08-15 ヘンリー エム．ジャクソン ファンデーション フォー ザ アドバンスメント オブ ミリタリー メディシン インチミンを単独で、または１以上の他の抗原との融合タンパク質として発現する宿主生物の投与による、免疫応答を刺激する方法
FR2748480B1 (fr) * 1996-05-09 1998-09-04 Biocem Plantes transgeniques exprimant la glycoproteine g de la rage, et glycoproteines ainsi obtenues
US20050032211A1 (en) * 1996-09-26 2005-02-10 Metabogal Ltd. Cell/tissue culturing device, system and method
IL155588A0 (en) * 2003-04-27 2003-11-23 Metabogal Ltd Methods for expression of enzymatically active recombinant lysosomal enzymes in transgenic plant root cells and vectors used thereby
US6664080B1 (en) 1997-04-22 2003-12-16 Bavarian Nordic Research Institute TaqMan™-PCR for the detection of pathogenic E. coli strains
US7422747B2 (en) 1997-10-07 2008-09-09 Loma Linda University Transgenic plant-based vaccines
US20050241024A1 (en) * 1997-10-07 2005-10-27 Langridge William H Transgenic plant-based vaccines
US6777546B2 (en) 1997-10-07 2004-08-17 Loma Linda University Methods and substances for preventing and treating autoimmune disease
SE9801852D0 (sv) * 1998-05-26 1998-05-26 Sbl Vaccin Ab Method of producing thy A-strains of Vibro cholerae, suck strains and their use
AU773953B2 (en) * 1998-12-22 2004-06-10 Boyce Thompson Institute For Plant Research Inc. Orally immunogenic bacterial enterotoxins expressed in transgenic plants
BR9916522A (pt) * 1998-12-23 2002-12-24 Thompson Boyce Plant Res Vetor de expressão de plantas, célula, semente vegetal, polinucleotìdeo, composição imunogênica, métodos para eliciar uma rsposta imune em mamìfero e para isolar polipeptìdeo, e, planta ou célula vegetal transgênicas
CA2397396A1 (en) * 2000-01-14 2001-07-19 Joseph M. Jilka Methods and compositions for obtaining disease protection for animals
AUPQ520800A0 (en) * 2000-01-21 2000-02-17 Alfred Hospital Prime-boost vaccination strategy
AU2001234592B2 (en) * 2000-01-27 2004-01-29 Loma Linda University Transgenic plant-based vaccines
US7081567B2 (en) * 2000-12-03 2006-07-25 Lexun Xue Transgenic dunaliella salina as a bioreactor
ITRM20010332A1 (it) * 2001-06-11 2002-12-11 Ist Superiore Sanita Vaccini a subunita' e procedimenti per la loro produzione.
US20040003432A1 (en) * 2002-05-06 2004-01-01 Pharmacia Corporation Production of hexosamines and uses thereof
US20060121468A1 (en) * 2002-06-26 2006-06-08 Allnutt F C T Viruses and virus-like particles for multiple antigen and target display
ES2224792B1 (es) 2002-06-28 2007-02-16 Era Plantech, S.L. Produccion de peptidos y proteinas por acumulacion de cuerpos proteicos derivados de reticulos endoplasmico en plantas.
AU2003274925A1 (en) * 2002-08-27 2004-03-19 Dow Agrosciences Llc Use of escherichia coli heat labile toxin as an adjuvant in birds and poultry
US20040117874A1 (en) * 2002-10-15 2004-06-17 Jianjun Yang Methods for accumulating translocated proteins
TWI350310B (en) 2002-12-13 2011-10-11 Novartis Ag Immunization of fish with plant-expressed recombinant proteins
CA2515779A1 (en) 2003-02-14 2004-09-02 The Curators Of The University Of Missouri Contraceptive method and compositions related to proteasomal interference
US7951557B2 (en) 2003-04-27 2011-05-31 Protalix Ltd. Human lysosomal proteins from plant cell culture
US20100196345A1 (en) * 2003-04-27 2010-08-05 Protalix Production of high mannose proteins in plant culture
AU2004235800B2 (en) * 2003-05-05 2010-02-18 Dow Agrosciences Llc Stable immunoprophylactic and therapeutic compositions derived from transgenic plant cells and methods for production
CN100393870C (zh) * 2003-05-05 2008-06-11 波依斯汤普森植物研究所 用于制备免疫保护性组合物的载体和来源于转基因植物的细胞
EP1522585A1 (en) * 2003-10-09 2005-04-13 Plant Research International B.V. Chimeric carrier molecules for the production of mucosal vaccines
JP4898432B2 (ja) 2004-05-31 2012-03-14 北里第一三共ワクチン株式会社 遺伝子組換え植物による抗原虫病経口ワクチン
DE602005022458D1 (de) 2004-09-10 2010-09-02 Asahi Glass Co Ltd Impfstoff gegen humanes papillomavirus zur oralen verabreichung
US7723570B2 (en) 2004-10-12 2010-05-25 Soymeds, Inc. Edible vaccines expressed in soybeans
EP1685848A1 (en) * 2005-01-26 2006-08-02 Plant Research International B.V. Oral vaccines for fish
NZ568562A (en) 2005-11-04 2011-03-31 Dow Agroscience Llc Preparation of vaccine master cell lines using recombinant plant suspension cultures
CA2630220C (en) * 2005-11-22 2020-10-13 Doris Coit Norovirus and sapovirus antigens
WO2007111500A1 (en) * 2006-03-27 2007-10-04 Plant Research International B.V. Immunization with transgenic mushrooms
SI2150608T1 (en) 2007-05-07 2018-04-30 Protalix Ltd. An extensive disposable bioreactor
US20110014231A1 (en) * 2007-11-05 2011-01-20 Mor Research Applications Ltd Anti-measles cancer immunotherapy
CN102016034B (zh) 2008-05-02 2014-11-05 出光兴产株式会社 细菌毒素疫苗
CN102356161A (zh) * 2009-03-19 2012-02-15 株式会社钟化 核酸的检测方法以及试剂盒、装置
KR101339703B1 (ko) * 2012-07-23 2013-12-11 전북대학교산학협력단 식물을 이용한 재조합 돼지 유행성 설사병 바이러스 (ｐｅｄｖ) 백신의 제조 방법 및 그에 따른 ｐｅｄｖ 백신
US20160213766A1 (en) * 2013-09-23 2016-07-28 Ventria Bioscience, Inc. OspA Fusion Protein for Vaccination against Lyme Disease
JP6523966B2 (ja) 2013-11-26 2019-06-05 出光興産株式会社 大腸菌性下痢症の予防

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US5612487A (en) * 1991-08-26 1997-03-18 Edible Vaccines, Inc. Anti-viral vaccines expressed in plants
UA48104C2 (uk) * 1991-10-04 2002-08-15 Новартіс Аг Фрагмент днк, який містить послідовність,що кодує інсектицидний протеїн, оптимізовану для кукурудзи,фрагмент днк, який забезпечує направлену бажану для серцевини стебла експресію зв'язаного з нею структурного гена в рослині, фрагмент днк, який забезпечує специфічну для пилку експресію зв`язаного з нею структурного гена в рослині, рекомбінантна молекула днк, спосіб одержання оптимізованої для кукурудзи кодуючої послідовності інсектицидного протеїну, спосіб захисту рослин кукурудзи щонайменше від однієї комахи-шкідника
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Also Published As

Publication number Publication date
AU691707B2 (en) 1998-05-21
DE69533964T2 (de) 2006-03-30
EP0793717B1 (en) 2005-01-26
WO1996012801A1 (en) 1996-05-02
NZ297142A (en) 2001-09-28
CA2203679A1 (en) 1996-05-02
AU4194096A (en) 1996-05-15
DE69533964D1 (de) 2005-03-03
EP0793717A1 (en) 1997-09-10
ES2235176T3 (es) 2005-07-01
US6194560B1 (en) 2001-02-27
ATE287947T1 (de) 2005-02-15
EP0793717A4 (en) 1998-11-25
JPH10507916A (ja) 1998-08-04
CA2203679C (en) 2010-08-17

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