MX9702092A - Compuestos de 1-acil-4-alifatilaminopiperidina. - Google Patents
Compuestos de 1-acil-4-alifatilaminopiperidina.Info
- Publication number
- MX9702092A MX9702092A MX9702092A MX9702092A MX9702092A MX 9702092 A MX9702092 A MX 9702092A MX 9702092 A MX9702092 A MX 9702092A MX 9702092 A MX9702092 A MX 9702092A MX 9702092 A MX9702092 A MX 9702092A
- Authority
- MX
- Mexico
- Prior art keywords
- alkyl
- amino
- substituted
- alkylene
- lower alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La invencion se refiere a novedosos compuestos de 1-acil-4-alifatilaminopiperidina de la formula I: en donde R1 es un radical de benzoílo, naftoílo, o cicloalcanoílo que está insustituido por alquilo inferior, alcoxi inferior, halogeno y/o trifluorometilo; R2 es cicloalquilo o un radical de fenilo o naftilo que está insustituido o sustituido por alquilo inferior, alcoxi inferior, halogeno, nitro, ciano, y/o trifluorometilo; R3 y R4 son juntos alquileno inferior o aza-, oxa-, o tia-alquileno inferior; o R3 es alquilo inferior, alcoxi inferior-alquilo inferior, dialquilo inferior-aminoalquilo inferior, o un radical de la formula -(CH2)n-C(=O)-R5(Ia); y R4 es hidrogeno, alquilo inferior, o un radical de la formula -(CH2)n-C(=O)-R5(Ia); R5 es (i) hidrogeno, alquilo, o alquilo que está sustituido por halogeno, alcoxi inferior, amino, o amino sustituido por alquilo inferior, aminoalquilo inferior, mono- o di-alquilo inferior-aminoalquilo, alcanoílo inferior, alcoxi inferior-carbonilo, o alquileno inferior, o aza-, oxa-, o tia-alquileno inferior, (ii) hidroxilo, cicloalcoxi, alcoxi inferior, o alcoxi inferior que está sustituido por alcoxi inferior que está sustituido por alcoxi inferior, amino, o amino sustituido por alquilo inferior, aminoalquilo inferior, mono- o di-alquilo inferior-aminoalquilo, alcanoílo inferior, alcoxi inferior-carbonilo, o alquileno inferior, o aza-, oxa-, o tia-alquileno inferior, o (iii) amino, o amino sustituido por alquilo inferior, cicloalquilo, aminoalquilo inferior, mono-o di-alquilo inferior, alcoxi inferior-carbonilo, o alquileno inferior, o aza-, -oxa-, o tia-alquileno inferior; X1 es metileno, etileno, un enlace directo, un grupo carbonilo libre o cetalizado, o un grupo hidroximetileno libre o eterificado; y n es 0 o 1, y sus sales, a procesos para la preparacion de los compuestos de acuerdo con la invencion, a composiciones farmacéuticas que los contienen, y a su uso como ingredientes activos farmacéuticos.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH2966/94-1 | 1994-09-30 | ||
| CH296694 | 1994-09-30 | ||
| PCT/EP1995/003681 WO1996010562A1 (en) | 1994-09-30 | 1995-09-19 | 1-acyl-4-aliphatylaminopiperidine compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX9702092A true MX9702092A (es) | 1997-10-31 |
| MXPA97002092A MXPA97002092A (es) | 1998-07-03 |
Family
ID=
Also Published As
| Publication number | Publication date |
|---|---|
| AU3607895A (en) | 1996-04-26 |
| FI971260A0 (fi) | 1997-03-26 |
| ATE212981T1 (de) | 2002-02-15 |
| NO971383L (no) | 1997-05-14 |
| FI971260A (fi) | 1997-03-26 |
| EP0783490B1 (en) | 2002-02-06 |
| DE69525355T2 (de) | 2002-09-19 |
| CA2198382A1 (en) | 1996-04-11 |
| ES2172595T3 (es) | 2002-10-01 |
| HUT77318A (hu) | 1998-03-30 |
| NO971383D0 (no) | 1997-03-24 |
| DE69525355D1 (de) | 2002-03-21 |
| DK0783490T3 (da) | 2002-05-13 |
| WO1996010562A1 (en) | 1996-04-11 |
| JPH10506399A (ja) | 1998-06-23 |
| EP0783490A1 (en) | 1997-07-16 |
| PT783490E (pt) | 2002-06-28 |
| US5935951A (en) | 1999-08-10 |
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