MX9605196A - HALOMETHYL AMIDES AS IL-1'beta' PROTEASE INHIBITORS. - Google Patents

HALOMETHYL AMIDES AS IL-1'beta' PROTEASE INHIBITORS.

Info

Publication number
MX9605196A
MX9605196A MX9605196A MX9605196A MX9605196A MX 9605196 A MX9605196 A MX 9605196A MX 9605196 A MX9605196 A MX 9605196A MX 9605196 A MX9605196 A MX 9605196A MX 9605196 A MX9605196 A MX 9605196A
Authority
MX
Mexico
Prior art keywords
beta
protease inhibitors
halomethyl
amides
halomethyl amides
Prior art date
Application number
MX9605196A
Other languages
Spanish (es)
Inventor
Roland E Dolle
James M Rinker
Original Assignee
Sanofi Winthrop Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Winthrop Inc filed Critical Sanofi Winthrop Inc
Publication of MX9605196A publication Critical patent/MX9605196A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
    • C07C233/13—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • C07C255/25—Aminoacetonitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C311/06—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by carboxyl groups

Abstract

Disclosed are compounds, compositions and methods for inhibiting interleukin-1'beta' protease activity, the compounds having formula (A) described herein.
MX9605196A 1994-04-29 1995-04-28 HALOMETHYL AMIDES AS IL-1'beta' PROTEASE INHIBITORS. MX9605196A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23642594A 1994-04-29 1994-04-29
PCT/US1995/005347 WO1995029672A1 (en) 1994-04-29 1995-04-28 HALOMETHYL AMIDES AS IL-1β PROTEASE INHIBITORS

Publications (1)

Publication Number Publication Date
MX9605196A true MX9605196A (en) 1997-12-31

Family

ID=22889450

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9605196A MX9605196A (en) 1994-04-29 1995-04-28 HALOMETHYL AMIDES AS IL-1'beta' PROTEASE INHIBITORS.

Country Status (9)

Country Link
EP (1) EP0758891A4 (en)
JP (1) JPH09512556A (en)
CN (1) CN1147201A (en)
AU (1) AU705321B2 (en)
CA (1) CA2189036A1 (en)
FI (1) FI964342A0 (en)
MX (1) MX9605196A (en)
NO (1) NO964472D0 (en)
WO (1) WO1995029672A1 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6204261B1 (en) 1995-12-20 2001-03-20 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β Converting enzyme inhibitors
US6008217A (en) * 1995-12-20 1999-12-28 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β converting enzyme
US5874424A (en) * 1995-12-20 1999-02-23 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β converting enzyme
US6420522B1 (en) 1995-06-05 2002-07-16 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β converting enzyme
WO1996030395A2 (en) * 1995-03-31 1996-10-03 Takeda Chemical Industries, Ltd. Cysteine protease inhibitor
US5843904A (en) * 1995-12-20 1998-12-01 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1βconverting enzyme
WO1999046248A1 (en) 1998-03-09 1999-09-16 Vertex Pharmaceuticals Incorporated 1,2-diazepane derivatives as interleukin-1beta converting enzyme inhibitors
DE69939689D1 (en) 1998-03-19 2008-11-20 Vertex Pharma CASPASE INHIBITORS
GB9922830D0 (en) 1999-09-27 1999-11-24 Novartis Ag Processes
ATE387199T1 (en) * 2000-01-06 2008-03-15 Merck Frosst Canada Ltd NEW SUBSTANCES AND COMPOUNDS AS PROTEASE INHIBITORS
PE20011350A1 (en) 2000-05-19 2002-01-15 Vertex Pharma PROPHARMAC OF AN INHIBITOR OF INTERLEUKIN-1ß CONVERTER ENZYME (ICE)
SI1533292T1 (en) 2002-08-30 2007-08-31 Japan Tobacco Inc Dibenzylamine compound and medicinal use thereof
CN100441186C (en) * 2003-12-03 2008-12-10 和记黄埔医药企业有限公司 Medical use of artificial lywrine
EP2295054A1 (en) 2004-05-27 2011-03-16 Vertex Pharmaceuticals Incorporated Ice inhibitors for the treatment of autoinflammatory diseases
US9956260B1 (en) 2011-07-22 2018-05-01 The J. David Gladstone Institutes Treatment of HIV-1 infection and AIDS

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1806291A1 (en) * 1968-10-31 1970-05-14 Badische Anilin Und & Soda Fab fungicide
US4195096A (en) * 1977-01-12 1980-03-25 Gaf Corporation Carboxylic amides as fungicides to eumycotina in phanerogamia plant life
DE2946910A1 (en) * 1979-11-21 1981-07-02 Hoechst Ag, 6230 Frankfurt FUNGICIDAL SULFONYL, BZW. SULFINYL ACETANILIDE
DE3122738A1 (en) * 1980-06-12 1982-03-18 CIBA-GEIGY AG, 4002 Basel "USE OF IODOACETAMIDE FOR CONTROLLING PAD ORGANISMS AND AGENT FOR CONTROLLING"
US4377587A (en) * 1980-07-25 1983-03-22 Ciba-Geigy Corporation Arylamine derivatives and use thereof as microbicides
JPS5798202A (en) * 1980-12-09 1982-06-18 Kumiai Chem Ind Co Ltd Herbicide
EP0059536B1 (en) * 1981-03-04 1987-04-22 Imperial Chemical Industries Plc Amide derivatives, processes for preparing them, their use as fungicides and pesticidal compositions containing them
DE3339351A1 (en) * 1983-10-29 1985-05-09 Bayer Ag, 5090 Leverkusen IODACETAMIDE
US4800211A (en) * 1986-08-18 1989-01-24 Merck & Co., Inc. 5-methylthio-3-hydroxybenzo [b]thiophene-2-carboxamide derivatives as cyclooxygenase and lipoxygenase inhibitors
US4874864A (en) * 1988-05-24 1989-10-17 Pfizer Inc. Benzamide protease inhibitors
US5258407A (en) * 1991-12-31 1993-11-02 Sterling Winthrop Inc. 3,4-disubstituted phenols-immunomodulating agents

Also Published As

Publication number Publication date
NO964472L (en) 1996-10-21
NO964472D0 (en) 1996-10-21
AU705321B2 (en) 1999-05-20
EP0758891A4 (en) 1997-12-03
FI964342A (en) 1996-10-28
EP0758891A1 (en) 1997-02-26
CN1147201A (en) 1997-04-09
JPH09512556A (en) 1997-12-16
AU2463495A (en) 1995-11-29
CA2189036A1 (en) 1995-11-09
WO1995029672A1 (en) 1995-11-09
FI964342A0 (en) 1996-10-28

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