MX9603975A - Compuesto de isoxazolina como inhibidores de la liberacion del factor de necrosis tumoral. - Google Patents

Compuesto de isoxazolina como inhibidores de la liberacion del factor de necrosis tumoral.

Info

Publication number
MX9603975A
MX9603975A MX9603975A MX9603975A MX9603975A MX 9603975 A MX9603975 A MX 9603975A MX 9603975 A MX9603975 A MX 9603975A MX 9603975 A MX9603975 A MX 9603975A MX 9603975 A MX9603975 A MX 9603975A
Authority
MX
Mexico
Prior art keywords
disease
isoxazoline compounds
inhibitors
compounds
alkyl
Prior art date
Application number
MX9603975A
Other languages
English (en)
Other versions
MXPA96003975A (es
Inventor
Victoria L Cohan
Edward F Kleinman
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MX9603975A publication Critical patent/MX9603975A/es
Publication of MXPA96003975A publication Critical patent/MXPA96003975A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Transplantation (AREA)
  • Nutrition Science (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Esta invencion se refiere a compuestos de isoxazolina que son inhibidores del factor de necrosis del tumor (TNF). Los compuestos de isoxazolina son utiles para la inhibicion del TNF en un mamífero en su necesidad y en el tratamiento o alivio de transtornos o enfermedades inflamatorias, que incluyen pero no se limitan a artritis reumatoide, osteoartritis, asma, bronquitis, enfermedad de las vías respiratorias obstructiva cronica, psoriasis, rinitis alérgica, dermatitis y enfermedad inflamatoria del intestino, sepsis, ataque séptico, tuberculosis, injerto frente a la enfermedad del huésped y caquexia asociada a SIDA o cáncer. Esta invencion también se refiere a las composiciones farmacéuticas utiles paraéstas que comprenden tales compuestos.
MXPA/A/1996/003975A 1994-03-09 1996-09-06 Compuestos de isoxazolina como inhibidores de la liberacion del factor de necrosis tumoral MXPA96003975A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US209125 1988-06-20
US20912594A 1994-03-09 1994-03-09
PCT/IB1995/000078 WO1995024398A1 (en) 1994-03-09 1995-02-03 Isoxazoline compounds as inhibitors of tnf release

Publications (2)

Publication Number Publication Date
MX9603975A true MX9603975A (es) 1997-09-30
MXPA96003975A MXPA96003975A (es) 1998-07-03

Family

ID=

Also Published As

Publication number Publication date
IL112847A0 (en) 1995-06-29
NO963746L (no) 1996-11-06
ATE169009T1 (de) 1998-08-15
WO1995024398A1 (en) 1995-09-14
ZA951909B (en) 1996-09-09
DK0749428T3 (da) 1998-11-16
MY114667A (en) 2002-12-31
US6114367A (en) 2000-09-05
ES2118557T3 (es) 1998-09-16
CN1143363A (zh) 1997-02-19
NO310496B1 (no) 2001-07-16
NO963746D0 (no) 1996-09-06
EP0749428A1 (en) 1996-12-27
CA2185019C (en) 2000-08-08
FI963510A0 (fi) 1996-09-06
US5869511A (en) 1999-02-09
IL112847A (en) 1999-10-28
EP0749428B1 (en) 1998-07-29
AU1464795A (en) 1995-09-25
AU684887B2 (en) 1998-01-08
DE69503769D1 (de) 1998-09-03
JPH09505082A (ja) 1997-05-20
KR100200449B1 (ko) 1999-06-15
NZ278667A (en) 2000-12-22
DE69503769T2 (de) 1998-12-03
FI963510A (fi) 1996-09-06

Similar Documents

Publication Publication Date Title
ZA951909B (en) Isoxazoline compounds as inhibitors of tnf release
MX9504020A (es) Compuestos de catecol dieter como inhibidores de la liberacion de factor de necrosis tumoral.
DE69426830D1 (en) Substituierte indole als phosphodiesterase typ iv inhibitoren
EP0874629A4 (en) ISOXAZOLINE, ISOTHIAZOLINE AND PYRAZOLINE AS FACTOR Xa INHIBITORS
DE69513285D1 (de) Hydroxyalkylammonium-pyrimidine und purine und nukleosidderivate zur inhibierung entzündlicher cytokine
IL154272A (en) Use of benzylideneaminoguanidines and hydroxyguanidines as melanocortin receptor ligands
KR970703975A (ko) 염증치토킨 억제제로서 유용한 n-치환-(디히드록시보릴) 알킬 푸린, 인돌 및 피리미딘 유도체(n-substituted-(dihydroxyboryl) purine, indole and pyrimidine derivatives, useful as inhibitors of inflammatory cytokines)
ES2195419T3 (es) Inhibidores bencenosulfonamida de pde-iv y su uso terapeutico.
MXPA03011409A (es) Derivados 6-(arilamido o arilamidometil)-naftalen-2-iloxiacidos como inhibidores del inhibidor tipo 1 de activador de plasminogeno (pai-1).
GEP20033029B (en) Substituted 1,8-Naphthyridin-4(1H)-Ones as Phosphodiesterase 4 Inhibitors
HRP980231B1 (en) Phosphodiesterase 4 - inhibiting diazepinoindolones
MY129491A (en) Hydrazono-malonitriles
CA2338073A1 (en) Novel urokinase inhibitors
CA2305058A1 (en) Polyalkylpyrrolidines and fuel compositions containing the same
ES2085519T3 (es) Procedimiento para la fabricacion de macromonomeros de polialquimetacrilato.
MXPA01007648A (es) Composiciones para mitigar la formacion de coque en hornos de descomposicion termica.
AU2321688A (en) Compositions comprising 1-oxo- or thiohydrocarbyl substituted azacycloalkanes
UA71004C2 (uk) Похідні 1-трифторометил-4-гідрокси-7-піперидиніламінометилхроману
HK1116188A1 (en) Chromane and thiochromane-3-yl-1,3-dihydroimidazoles as inhibitors of dopamine-beta-hydroxylase and methods of their preparation
MXPA05005414A (es) Derivados de propargil-trifluorometoxi-amino-benzotiazol.
TNSN01085A1 (en) Carboxyalkylether-acat inhibitor combinations
GR1002589B (el) Ενωσεις τριαρυλο ιμιδαζολης.

Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees