MX9602977A - Proteinas que reparan la mala union de adn humano. - Google Patents

Proteinas que reparan la mala union de adn humano.

Info

Publication number
MX9602977A
MX9602977A MX9602977A MX9602977A MX9602977A MX 9602977 A MX9602977 A MX 9602977A MX 9602977 A MX9602977 A MX 9602977A MX 9602977 A MX9602977 A MX 9602977A MX 9602977 A MX9602977 A MX 9602977A
Authority
MX
Mexico
Prior art keywords
human dna
proteins
repair proteins
mismatch repair
dna mismatch
Prior art date
Application number
MX9602977A
Other languages
English (en)
Inventor
William A Haseltine
Steven M Ruben
Ying-Fei Wei
Mark D Adams
Robert D Fleischmann
Claire M Fraser
Rebeca A Fuldner
Ewen F Kirkness
Craig A Rosen
Original Assignee
Human Genome Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/187,757 external-priority patent/US6482606B1/en
Priority claimed from US08/294,312 external-priority patent/US6380369B1/en
Application filed by Human Genome Sciences Inc filed Critical Human Genome Sciences Inc
Publication of MX9602977A publication Critical patent/MX9602977A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invencion describe tres proteínas de reparacion de ADN humano y el ADN (ARN) que codifica para tales proteínas, y un procedimiento para la produccion de tales proteínas mediante técnicas recombinantes. Una de las proteínas para la reparacion del ADN humano, hMLH1, ha sido trazada en mapa al cromosoma 3, mientras que hMLH2 ha sido trazada en mapa al cromosoma 2, y hMLH3 ha sido trazada en mapa al cromosoma 7. La invencion proporciona los métodos para el diagnostico de las alteraciones en los genes hMLH1, hMLH2 y hMLH3.
MX9602977A 1994-01-27 1996-07-24 Proteinas que reparan la mala union de adn humano. MX9602977A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/187,757 US6482606B1 (en) 1994-01-27 1994-01-27 Human DNA mismatch repair polynucleotides
US08/210,143 US6620619B2 (en) 1994-01-27 1994-03-16 Human DNA mismatch repair protein
US08/294,312 US6380369B1 (en) 1994-01-27 1994-08-23 Human DNA mismatch repair proteins

Publications (1)

Publication Number Publication Date
MX9602977A true MX9602977A (es) 1998-01-31

Family

ID=27392292

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9602977A MX9602977A (es) 1994-01-27 1996-07-24 Proteinas que reparan la mala union de adn humano.

Country Status (9)

Country Link
US (3) US6416984B1 (es)
EP (1) EP0749496A4 (es)
JP (3) JP3732509B2 (es)
AU (1) AU697269B2 (es)
CA (1) CA2182206A1 (es)
IL (1) IL112453A0 (es)
MX (1) MX9602977A (es)
NZ (1) NZ281023A (es)
WO (1) WO1995020678A1 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7396678B1 (en) 1993-11-17 2008-07-08 Dana-Farber Cancer Institute Method for detection of alterations in the DNA mismatch repair pathway
US7229755B1 (en) 1993-11-17 2007-06-12 Dana Farber Cancer Institute, Inc. Method for detection of alterations in the DNA mismatch repair pathway
US6191268B1 (en) * 1993-12-17 2001-02-20 Dana-Farber Cancer Institute Compositions and methods relating to DNA mismatch repair genes
CA2182206A1 (en) * 1994-01-27 1995-08-03 William A. Haseltine Human dna mismatch repair proteins
US7022472B2 (en) 1998-10-22 2006-04-04 Diadexus, Inc. Mutations in human MLH1 and human MSH2 genes useful in diagnosing colorectal cancer
WO2002024741A2 (en) 2000-09-21 2002-03-28 Ryan James W Isolated genomic polynucleotide fragments from chromosome 7
WO2002061085A2 (en) 2000-10-31 2002-08-08 Ryan James W Isolated genomic polynucleotide fragments from the p15 region of chromosome 11
JP2007537709A (ja) * 2003-05-23 2007-12-27 モーフオテク・インコーポレーテツド 腫瘍抗原を特異的に結合するモノクローナル抗体
CA2548813A1 (en) * 2003-12-08 2005-06-23 Morphotek, Inc. Antibodies that specifically bind pms2
JP4805848B2 (ja) * 2004-02-12 2011-11-02 モルフォテック、インク． 腫瘍抗原の生物活性を特異的に阻止するモノクローナル抗体
EP2322560B1 (en) * 2005-03-10 2013-09-04 Morphotek, Inc. Anti-mesothelin antibodies
EP1879922A2 (en) 2005-04-22 2008-01-23 Morphotek, Inc. Antibodies with immune effector activity and that internalize in folate receptor alpha-positive cells
WO2008103475A1 (en) * 2007-02-20 2008-08-28 Anaptysbio, Inc. Somatic hypermutation systems
US11859246B2 (en) 2013-12-11 2024-01-02 Accuragen Holdings Limited Methods and compositions for enrichment of amplification products
CA2933343A1 (en) 2013-12-11 2015-06-18 Accuragen, Inc. Compositions and methods for detecting rare sequence variants
US11286519B2 (en) 2013-12-11 2022-03-29 Accuragen Holdings Limited Methods and compositions for enrichment of amplification products
WO2017062863A1 (en) 2015-10-09 2017-04-13 Accuragen Holdings Limited Methods and compositions for enrichment of amplification products
WO2017201102A1 (en) 2016-05-16 2017-11-23 Accuragen Holdings Limited Method of improved sequencing by strand identification
JP6966052B2 (ja) 2016-08-15 2021-11-10 アキュラーゲン ホールディングス リミテッド 稀な配列変異体を検出するための組成物および方法
US11203782B2 (en) 2018-03-29 2021-12-21 Accuragen Holdings Limited Compositions and methods comprising asymmetric barcoding

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4737454A (en) 1983-07-14 1988-04-12 Molecular Diagnostics, Inc. Fast photochemical method of labelling nucleic acids for detection purposes in hybridization assays
US5124443A (en) 1989-05-16 1992-06-23 University Of Kansas cDNA clones encoding chicken egg white cystatin
AU8116494A (en) 1993-11-12 1995-06-13 Kenichi Matsubara Gene signature
US7229755B1 (en) 1993-11-17 2007-06-12 Dana Farber Cancer Institute, Inc. Method for detection of alterations in the DNA mismatch repair pathway
ATE273387T1 (de) 1993-12-02 2004-08-15 Univ Johns Hopkins Menschliches mutator-gen nmsh2 und seine verbindung zum hereditaren, nichtpolypösen kolorrektalen karzinom
US6191268B1 (en) 1993-12-17 2001-02-20 Dana-Farber Cancer Institute Compositions and methods relating to DNA mismatch repair genes
US5922855A (en) 1993-12-17 1999-07-13 Oregon Health Sciences University Mammalian DNA mismatch repair genes MLH1 and PMS1
CA2182206A1 (en) * 1994-01-27 1995-08-03 William A. Haseltine Human dna mismatch repair proteins
US6380369B1 (en) * 1994-01-27 2002-04-30 Human Genome Sciences, Inc. Human DNA mismatch repair proteins

Also Published As

Publication number Publication date
AU1733095A (en) 1995-08-15
EP0749496A4 (en) 1999-03-03
IL112453A0 (en) 1995-03-30
JPH09508280A (ja) 1997-08-26
NZ281023A (en) 1998-04-27
JP2005323601A (ja) 2005-11-24
US6416984B1 (en) 2002-07-09
WO1995020678A1 (en) 1995-08-03
EP0749496A1 (en) 1996-12-27
JP3752457B2 (ja) 2006-03-08
US20030027177A1 (en) 2003-02-06
JP2002325588A (ja) 2002-11-12
CA2182206A1 (en) 1995-08-03
US6610477B1 (en) 2003-08-26
JP3732509B2 (ja) 2006-01-05
AU697269B2 (en) 1998-10-01

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