MX9602951A - Composiciones de metronidazol de liberacion modificada y metodos para fabricar y utilizar las mismas. - Google Patents
Composiciones de metronidazol de liberacion modificada y metodos para fabricar y utilizar las mismas.Info
- Publication number
- MX9602951A MX9602951A MX9602951A MX9602951A MX9602951A MX 9602951 A MX9602951 A MX 9602951A MX 9602951 A MX9602951 A MX 9602951A MX 9602951 A MX9602951 A MX 9602951A MX 9602951 A MX9602951 A MX 9602951A
- Authority
- MX
- Mexico
- Prior art keywords
- percent
- metronidazole
- aqueous
- compositions
- aqueous soluble
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Composiciones farmacéuticas que tiene un perfil de liberacion modificado para la dosificacion una vez al día de metronidazol, métodos para fabricar las composiciones farmacéuticas, y métodos para tratar una infeccion microbiana con la dosificacion una vez al día de las composiciones farmacéuticas de la invencion, son provistos. Las composiciones dadas una vez al día exhiben una bioequivalencia substancial con respecto al metrodinazol de liberacion inmediata dado tres veces al día. Las composiciones de la invencion comprenden: (a) una primera porcion de metronidazol la cual es de aproximadamente 53% peso hasta aproximadamente 79% peso de metronidazol; (b) aproximadamente 1.5% peos hasta aproximadamente 3.0% peso de un copolímero de éster del ácido poli(met)acrílico insoluble, acuoso, el cual es permeable al agua, expansible en el agua e independiente del pH; (c) aproximadamente 0.1% peso hasta aproximadamente 2.0% peso del agente de desunion; (d) 0 hasta aproximadamente 23% peso de un primer diluyente farmacéutico soluble acuoso; (e) 0 hasta aproximadamente 23% peso de un segundo diluyente soluble, acuoso, el cual es adecuado para formar una tableta farmacéutica cuando se comprimen con los gránulos de (a), el segundo diluyente soluble acuoso que es el mismo que o diferente del primer diluyente soluble acuoso; (f) 0 hasta aproximadamente 20% peso de una segunda porcion de metronidazol; (g) 0 hasta aproximadamente 0.2% peso del agente de deslizamiento; y (h) 0 hasta aproximadamente 2% peso del lubricante, en donde la composicion comprende gránulos que contienen metronidazol, que comprenden (a), (b), (c) y (d), en donde la suma de los porcentajes en peso del metronidazol provisto pro (a) y (f) está entre aproximadamente 72% peso y aproximadamente 79% peso, y en donde la suma de los porcentajes en peos del diluyente soluble acuoso provisto por (d) y (e) está entre aproximadamente 16% peso y aproximadamente 23% peso.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/187,568 US6103262A (en) | 1994-01-27 | 1994-01-27 | Modified-release metronidazole compositions and methods for making and using same |
| PCT/US1995/000005 WO1995020383A1 (en) | 1994-01-27 | 1995-01-04 | Modified-release metronidazole compositions and methods for making and using same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX9602951A true MX9602951A (es) | 1997-06-28 |
Family
ID=22689500
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX9602951A MX9602951A (es) | 1994-01-27 | 1995-01-04 | Composiciones de metronidazol de liberacion modificada y metodos para fabricar y utilizar las mismas. |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US6103262A (es) |
| EP (1) | EP0744947B1 (es) |
| JP (1) | JPH09508381A (es) |
| KR (1) | KR100368769B1 (es) |
| CN (1) | CN1095665C (es) |
| AT (1) | ATE216236T1 (es) |
| AU (1) | AU682248B2 (es) |
| BR (1) | BR9506662A (es) |
| CA (1) | CA2181985C (es) |
| DE (1) | DE69526434T2 (es) |
| DK (1) | DK0744947T3 (es) |
| ES (1) | ES2174930T3 (es) |
| MX (1) | MX9602951A (es) |
| NZ (1) | NZ279368A (es) |
| PT (1) | PT744947E (es) |
| WO (1) | WO1995020383A1 (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999004829A1 (en) | 1997-07-28 | 1999-02-04 | Redmond Mary L | Composition and process for the treatment of epidermal traumas such as decubitus ulcers |
| US6322819B1 (en) | 1998-10-21 | 2001-11-27 | Shire Laboratories, Inc. | Oral pulsed dose drug delivery system |
| DE19850445A1 (de) * | 1998-11-02 | 2000-05-04 | Falk Pharma Gmbh | Arzneimittel zur topischen Behandlung entzündlicher Darmerkrankungen |
| ECSP003851A (es) * | 1999-12-22 | 2002-05-23 | Pharmacia Corp | Composicon de liberacion doble de un inhibidor ciclooxigenasa-2 |
| US6423707B1 (en) | 2000-08-28 | 2002-07-23 | California Pacific Medical Center | Nitroimidazole ester analogues and therapeutic applications |
| US8846100B2 (en) | 2006-05-12 | 2014-09-30 | Shire Llc | Controlled dose drug delivery system |
| US20130259947A1 (en) | 2010-11-29 | 2013-10-03 | Dr. Reddy's Laboratories Ltd. | Oral metronidazole pharmaceutical compositions |
| US20140377347A1 (en) * | 2012-01-23 | 2014-12-25 | Ranbaxy Laboratories Limited | In-situ multilayered tablet technology |
| AU2015311674B2 (en) | 2014-09-05 | 2018-03-08 | Lupin Inc. | Secnidazole for use in the treatment of bacterial vaginosis |
| CA2988082C (en) * | 2015-06-01 | 2020-09-29 | Symbiomix Therapeutics, Llc | Novel nitroimidazole formulations and uses thereof |
| WO2017027528A1 (en) * | 2015-08-10 | 2017-02-16 | Purdue Research Foundation | Methods and systems for depositing active ingredients on substrates |
| GR1008992B (el) | 2015-12-17 | 2017-03-23 | Verisfield (Uk) Ltd, Υποκαταστημα Ελλαδας, Εμπορια Φαρμακων | Φαρμακευτικη συνθεση σε μορφη κοκκιων για χορηγηση απο το στομα που περιεχει μετρονιδαζολη ή παραγωγα αυτης και εναν παραγοντα καλυψης της γευσης |
| CN112007002B (zh) * | 2020-08-05 | 2022-08-12 | 河北君临药业有限公司 | 一种质量稳定的甲硝唑片剂组合物及其制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2944061A (en) * | 1957-09-20 | 1960-07-05 | Acyl derivatives and process | |
| FI63335B (fi) * | 1979-02-02 | 1983-02-28 | Orion Yhtymae Oy | Foerfarande foer framstaellning av tabletter med foerdroejd loslighet av effektaemne |
| JPS6056122B2 (ja) * | 1980-05-21 | 1985-12-09 | 塩野義製薬株式会社 | 徐放性製剤 |
| GB8707416D0 (en) * | 1987-03-27 | 1987-04-29 | Wellcome Found | Pharmaceutical formulations |
| US4927639A (en) * | 1989-02-02 | 1990-05-22 | Warner-Lambert Company | Modified release gemfibrozil composition |
| DE4125048A1 (de) * | 1991-07-29 | 1993-02-04 | Peggy Albrecht | Arzneimittel mit verzoegerter freisetzung zur behandlung von periodontitis |
| CA2093282C (en) * | 1992-05-04 | 1999-01-12 | Tibor Sipos | Intraoral medicament-releasing device |
-
1994
- 1994-01-27 US US08/187,568 patent/US6103262A/en not_active Expired - Fee Related
-
1995
- 1995-01-04 NZ NZ279368A patent/NZ279368A/en unknown
- 1995-01-04 DK DK95907963T patent/DK0744947T3/da active
- 1995-01-04 AU AU15967/95A patent/AU682248B2/en not_active Ceased
- 1995-01-04 CN CN95191364A patent/CN1095665C/zh not_active Expired - Fee Related
- 1995-01-04 PT PT95907963T patent/PT744947E/pt unknown
- 1995-01-04 WO PCT/US1995/000005 patent/WO1995020383A1/en active IP Right Grant
- 1995-01-04 EP EP95907963A patent/EP0744947B1/en not_active Expired - Lifetime
- 1995-01-04 MX MX9602951A patent/MX9602951A/es not_active IP Right Cessation
- 1995-01-04 KR KR1019960703863A patent/KR100368769B1/ko not_active IP Right Cessation
- 1995-01-04 AT AT95907963T patent/ATE216236T1/de not_active IP Right Cessation
- 1995-01-04 BR BR9506662A patent/BR9506662A/pt not_active IP Right Cessation
- 1995-01-04 JP JP7520048A patent/JPH09508381A/ja not_active Ceased
- 1995-01-04 CA CA002181985A patent/CA2181985C/en not_active Expired - Fee Related
- 1995-01-04 ES ES95907963T patent/ES2174930T3/es not_active Expired - Lifetime
- 1995-01-04 DE DE69526434T patent/DE69526434T2/de not_active Expired - Fee Related
- 1995-05-19 US US08/445,309 patent/US5618559A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU1596795A (en) | 1995-08-15 |
| JPH09508381A (ja) | 1997-08-26 |
| DE69526434T2 (de) | 2002-10-31 |
| CN1095665C (zh) | 2002-12-11 |
| US5618559A (en) | 1997-04-08 |
| US6103262A (en) | 2000-08-15 |
| BR9506662A (pt) | 1997-11-18 |
| EP0744947A1 (en) | 1996-12-04 |
| CA2181985A1 (en) | 1995-08-03 |
| NZ279368A (en) | 1998-04-27 |
| ATE216236T1 (de) | 2002-05-15 |
| AU682248B2 (en) | 1997-09-25 |
| CA2181985C (en) | 2000-12-05 |
| WO1995020383A1 (en) | 1995-08-03 |
| ES2174930T3 (es) | 2002-11-16 |
| PT744947E (pt) | 2002-08-30 |
| KR100368769B1 (ko) | 2003-05-16 |
| EP0744947B1 (en) | 2002-04-17 |
| DE69526434D1 (de) | 2002-05-23 |
| CN1139382A (zh) | 1997-01-01 |
| DK0744947T3 (da) | 2002-07-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration | ||
| MM | Annulment or lapse due to non-payment of fees |