MX9602034A - Retinoid-like compounds. - Google Patents
Retinoid-like compounds.Info
- Publication number
- MX9602034A MX9602034A MX9602034A MX9602034A MX9602034A MX 9602034 A MX9602034 A MX 9602034A MX 9602034 A MX9602034 A MX 9602034A MX 9602034 A MX9602034 A MX 9602034A MX 9602034 A MX9602034 A MX 9602034A
- Authority
- MX
- Mexico
- Prior art keywords
- alkyl
- formula
- independently hydrogen
- compound
- nhcs
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
Abstract
The present invention relates to a compound of formula (see formula) or a nontoxic pharmaceutically acceptable salt, physiologically hydrolyzable ester or solvate thereof, in which X is -O-CO-, -NH-CO-, -CS-NH-, -CO-O-, -CO-O-, -CO-NH-, -COS-, -SCO-, -SCH2-, -CH2-CH2-, -C(C-, -CH2,-NH-, -COCH2-, -NHCS-, -NHCS-, -CH2S-; -CH2O-, -OCH2-, -NHCH2- or -CR5=CR6-; Rm and Rk are independently hydrogen, halogen, C1-6 alkyl, hydroxy, C1-6 alkyloxy or nitro; n is zero or one; R4 is -(CH2)t-Y, C1-6 alkyl, or C3-6 cycloalkyl; R1 is -CO2Z, C1-6alkyl, CH2OH, -CONHRy , or CHO; R2 and R3 are independently hydrogen or C1-6 alkyl alkyl; Ra and Rb are independently hydrogen or C1-6 alkyl; but when n is one, Ra and Rb together can form a radical of the formula (see formula); Y is naphthyl or phenyl, both radicals can be optionally substituted with one to three same or different C1-6 alkyl or halogen; Z is hydrogen or C1-6 alkyl;R5, R6 and Ry are independently hydrogen or C1-6 alkyl; and t is zero to six. Also porivided by this invention are methods for preventing and/or treating tumors, arthritis and nonmalignant skin disorders comprising administering a compound of formula Y to a mammal. Further provided is a pharmaceutical formulation (composition) comprising a compound of formula Y in admixture with (a) pharmaceutically acceptable excipient (s).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/464,186 US5648385A (en) | 1994-01-03 | 1995-06-05 | Retinoid-like compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9602034A true MX9602034A (en) | 1997-08-30 |
Family
ID=23842896
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9602034A MX9602034A (en) | 1995-06-05 | 1996-05-29 | Retinoid-like compounds. |
Country Status (11)
Country | Link |
---|---|
KR (1) | KR970000224A (en) |
CN (1) | CN1144217A (en) |
CZ (1) | CZ160996A3 (en) |
HU (1) | HU218963B (en) |
IL (1) | IL118528A (en) |
MX (1) | MX9602034A (en) |
NO (1) | NO305946B1 (en) |
RU (1) | RU2163590C2 (en) |
SG (1) | SG42412A1 (en) |
TW (1) | TW418186B (en) |
ZA (1) | ZA964264B (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2020142865A1 (en) * | 2019-01-07 | 2020-07-16 | 江苏凯迪恩医药科技有限公司 | Benzamide compound, intermediates, preparation method, and application |
RU2714932C1 (en) * | 2019-09-26 | 2020-02-21 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Саратовский национальный исследовательский государственный университет имени Н.Г. Чернышевского" | Agent possessing cytotoxic activity |
-
1996
- 1996-05-15 TW TW085105756A patent/TW418186B/en active
- 1996-05-27 ZA ZA9604264A patent/ZA964264B/en unknown
- 1996-05-29 NO NO962168A patent/NO305946B1/en not_active IP Right Cessation
- 1996-05-29 MX MX9602034A patent/MX9602034A/en unknown
- 1996-06-02 IL IL11852896A patent/IL118528A/en active IP Right Grant
- 1996-06-03 CZ CZ961609A patent/CZ160996A3/en unknown
- 1996-06-04 HU HU9601518A patent/HU218963B/en not_active IP Right Cessation
- 1996-06-04 SG SG1996009977A patent/SG42412A1/en unknown
- 1996-06-04 RU RU96111015/04A patent/RU2163590C2/en active
- 1996-06-05 CN CN96105345A patent/CN1144217A/en active Pending
- 1996-06-05 KR KR1019960020024A patent/KR970000224A/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
HU218963B (en) | 2001-01-29 |
SG42412A1 (en) | 1997-08-15 |
CZ160996A3 (en) | 1997-02-12 |
NO305946B1 (en) | 1999-08-23 |
HU9601518D0 (en) | 1996-07-29 |
KR970000224A (en) | 1997-01-21 |
NO962168L (en) | 1996-12-06 |
NO962168D0 (en) | 1996-05-29 |
ZA964264B (en) | 1997-11-27 |
IL118528A (en) | 2001-04-30 |
RU2163590C2 (en) | 2001-02-27 |
TW418186B (en) | 2001-01-11 |
IL118528A0 (en) | 1996-06-02 |
HUP9601518A2 (en) | 1997-05-28 |
HUP9601518A3 (en) | 1997-06-30 |
CN1144217A (en) | 1997-03-05 |
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