MX9401408A - Nuevos derivados heterociclicos. - Google Patents
Nuevos derivados heterociclicos.Info
- Publication number
- MX9401408A MX9401408A MX9401408A MX9401408A MX9401408A MX 9401408 A MX9401408 A MX 9401408A MX 9401408 A MX9401408 A MX 9401408A MX 9401408 A MX9401408 A MX 9401408A MX 9401408 A MX9401408 A MX 9401408A
- Authority
- MX
- Mexico
- Prior art keywords
- alkyl
- suitable substituent
- pct
- hydrogen
- heterocyclic group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Esta invención se relaciona con nuevos derivados heterociclicos. Más particularmente, esta invención se relaciona con derivados pirazol y sus sales farmacéuticamente aceptables, los cuales tienen actividades farmacológicas, con procesos para su preparación, con una composición farmacéutica que los comprende y el uso de los mismos. Por consiguiente, un aspecto de esta invención es el de proporcionar nuevos y útiles derivados de pirazol y sus sales farmacéuticamente aceptables, las cuales poseen una fuerte actividad inhibidora sobre la producción de la Interleucina-1 (IL-1) y una fuerte actividad inhibidora sobre la producción del factor de necrosis necrosis (TNF). Otro objeto de esta invención, es el de proporcionar procesos para la preparación de los derivados pirazol y sus sales. Otro objeto de esta invención, es el de proporcionar una composición farmacéutica, que comprende los derivados pirazol o sales farmacéuticamente aceptables. Aún otro objeto de esta invención, es el de proporcionar un uso los derivados pirazol o una sal de los mismos farmacéuticamente aceptables, como un medicamento para el tratamiento profiláctico y terapéutico de enfermedades mediadas por IL-1 y TNF tales como enfermedades inflamatorias crónicas, enfermedades autoinmunes específicas, lesión a órganos inducidas por sepsis y similares en seres humanos y animales.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939303993A GB9303993D0 (en) | 1993-02-26 | 1993-02-26 | New heterocyclic derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX9401408A true MX9401408A (es) | 1994-08-31 |
Family
ID=10731142
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX9401408A MX9401408A (es) | 1993-02-26 | 1994-02-24 | Nuevos derivados heterociclicos. |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5670503A (es) |
| EP (1) | EP0686156B1 (es) |
| JP (1) | JP3569917B2 (es) |
| KR (1) | KR100313615B1 (es) |
| CN (1) | CN1041929C (es) |
| AT (1) | ATE220677T1 (es) |
| AU (1) | AU681625B2 (es) |
| CA (1) | CA2156919A1 (es) |
| DE (1) | DE69430988T2 (es) |
| DK (1) | DK0686156T3 (es) |
| ES (1) | ES2176235T3 (es) |
| GB (1) | GB9303993D0 (es) |
| HU (1) | HUT70832A (es) |
| IL (1) | IL108562A (es) |
| MX (1) | MX9401408A (es) |
| PT (1) | PT686156E (es) |
| RU (1) | RU2124517C1 (es) |
| TW (1) | TW260669B (es) |
| WO (1) | WO1994019350A1 (es) |
| ZA (1) | ZA94787B (es) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101817784B (zh) | 1996-04-25 | 2012-02-01 | 日产化学工业株式会社 | 乙烯衍生物和含有该衍生物的杀有害生物剂 |
| EP1019394A1 (en) | 1997-05-22 | 2000-07-19 | G.D. Searle & Co. | PYRAZOLE DERIVATIVES AS p38 KINASE INHIBITORS |
| US6979686B1 (en) | 2001-12-07 | 2005-12-27 | Pharmacia Corporation | Substituted pyrazoles as p38 kinase inhibitors |
| US6514977B1 (en) * | 1997-05-22 | 2003-02-04 | G.D. Searle & Company | Substituted pyrazoles as p38 kinase inhibitors |
| CA2293436C (en) | 1997-06-12 | 2010-10-26 | Rhone-Poulenc Rorer Limited | Imidazolyl-cyclic acetals as tnf inhibitors |
| US20020156104A1 (en) | 1997-06-13 | 2002-10-24 | Jerry L. Adams | Novel pyrazole and pyrazoline substituted compounds |
| ES2237850T3 (es) * | 1997-10-14 | 2005-08-01 | Mitsubishi Pharma Corporation | Compuestos de piperazina y su uso medicinal. |
| WO1999032121A1 (en) | 1997-12-19 | 1999-07-01 | Smithkline Beecham Corporation | Compounds of heteroaryl substituted imidazole, their pharmaceutical compositions and uses |
| US6858617B2 (en) | 1998-05-26 | 2005-02-22 | Smithkline Beecham Corporation | Substituted imidazole compounds |
| EP1112070B1 (en) * | 1998-08-20 | 2004-05-12 | Smithkline Beecham Corporation | Novel substituted triazole compounds |
| DE69914357T2 (de) | 1998-11-04 | 2004-11-11 | Smithkline Beecham Corp. | Pyridin-4-yl oder pyrimidin-4-yl substituierte pyrazine |
| EP1208748A4 (en) * | 1999-08-31 | 2002-11-20 | Fujisawa Pharmaceutical Co | PRESERVATIVES FOR ORGANS |
| US7253169B2 (en) | 1999-11-12 | 2007-08-07 | Gliamed, Inc. | Aza compounds, pharmaceutical compositions and methods of use |
| US6417189B1 (en) * | 1999-11-12 | 2002-07-09 | Gpi Nil Holdings, Inc. | AZA compounds, pharmaceutical compositions and methods of use |
| JP2003514900A (ja) | 1999-11-23 | 2003-04-22 | スミスクライン・ビーチャム・コーポレイション | ＣＳＢＰ／ｐ３８キナーゼ阻害剤としての３，４−ジヒドロ−（１Ｈ）−キナゾリン−２−オン化合物 |
| US6759410B1 (en) | 1999-11-23 | 2004-07-06 | Smithline Beecham Corporation | 3,4-dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors |
| WO2001038312A1 (en) | 1999-11-23 | 2001-05-31 | Smithkline Beecham Corporation | 3,4-DIHYDRO-(1H)QUINAZOLIN-2-ONE COMPOUNDS AS CSBP/p38 KINASE INHIBITORS |
| WO2001038313A1 (en) | 1999-11-23 | 2001-05-31 | Smithkline Beecham Corporation | 3,4-DIHYDRO-(1H)QUINAZOLIN-2-ONE COMPOUNDS AS CSBP/p39 kINASE INHIBITORS |
| US7235551B2 (en) | 2000-03-02 | 2007-06-26 | Smithkline Beecham Corporation | 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases |
| NZ524806A (en) | 2000-10-23 | 2006-03-31 | Smithkline Beecham Corp | Tri-substituted 8H-pyrido[2,3-d]pyrimidin-7-one compounds |
| US6583143B2 (en) * | 2000-12-28 | 2003-06-24 | Neurocrine Biosciences, Inc. | CRF receptor antagonists and methods relating thereto |
| PT1397364E (pt) * | 2001-05-24 | 2007-10-22 | Lilly Co Eli | Novos derivados de pirrole como agentes farmacêuticos |
| RU2004133811A (ru) | 2002-04-19 | 2005-04-20 | Смитклайн Бичам Корпорейшн (US) | Новые соединения |
| EP1707205A2 (en) | 2002-07-09 | 2006-10-04 | Boehringer Ingelheim Pharma GmbH & Co. KG | Pharmaceutical compositions of anticholinergics and p38 kinase inhibitors in the treatment of respiratory diseases |
| EP1572113B1 (en) * | 2002-08-26 | 2017-05-17 | Takeda Pharmaceutical Company Limited | Calcium receptor modulating compound and use thereof |
| ATE490244T1 (de) | 2003-01-27 | 2010-12-15 | Merck Sharp & Dohme | Substituierte pyrazole, zusammensetzungen,die solche verbindungen enthalten, und anwendungsverfahren |
| MY143599A (en) * | 2004-06-04 | 2011-06-15 | Merck Sharp & Dohme | Pyrazole derivatives, compositions containing such compounds and methods of use |
| US20060035893A1 (en) | 2004-08-07 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders |
| PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
| UY29440A1 (es) | 2005-03-25 | 2006-10-02 | Glaxo Group Ltd | Nuevos compuestos |
| JP2008535822A (ja) | 2005-03-25 | 2008-09-04 | グラクソ グループ リミテッド | 新規化合物 |
| PE20061193A1 (es) | 2005-03-25 | 2006-12-02 | Glaxo Group Ltd | DERIVADOS DE 3,4-DIHIDROPIRIMIDO[4,5-d]PIRIMIDIN-2-[1H]-0NA COMO INHIBIDORES DE QUINASA p38 |
| WO2006104917A2 (en) | 2005-03-25 | 2006-10-05 | Glaxo Group Limited | Process for preparing pyrido[2,3-d]pyrimidin-7-one and 3,4-dihydropyrimido[4,5-d]pyrimidin-2(1h)-one derivatives |
| EP1910303A2 (en) * | 2005-07-26 | 2008-04-16 | Merck & Co., Inc. | Process for synthesizing a substituted pyrazole |
| EP1992344A1 (en) | 2007-05-18 | 2008-11-19 | Institut Curie | P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation |
| US20110195962A1 (en) * | 2007-08-16 | 2011-08-11 | Alcon Research, Ltd. | Use of multi-pharmacophore compounds to treat nasal disorders |
| CA2700327A1 (en) * | 2007-09-20 | 2009-03-26 | Wyeth Llc | Pyrazolo[5, 1-c] [1,2,4] triazines, methods for preparation and use thereof |
| CN101441969B (zh) | 2007-11-23 | 2010-07-28 | 清华大学 | 场发射像素管 |
| CN101441972B (zh) | 2007-11-23 | 2011-01-26 | 鸿富锦精密工业（深圳）有限公司 | 场发射像素管 |
| EP2402344A1 (en) * | 2010-06-29 | 2012-01-04 | Basf Se | Pyrazole fused bicyclic compounds |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992012154A1 (en) * | 1990-12-31 | 1992-07-23 | Fujisawa Pharmaceutical Co., Ltd. | Imidazotriazine derivatives |
| US5356897A (en) * | 1991-09-09 | 1994-10-18 | Fujisawa Pharmaceutical Co., Ltd. | 3-(heteroaryl)-pyrazololi[1,5-a]pyrimidines |
-
1993
- 1993-02-26 GB GB939303993A patent/GB9303993D0/en active Pending
-
1994
- 1994-02-04 ZA ZA94787A patent/ZA94787B/xx unknown
- 1994-02-04 IL IL108562A patent/IL108562A/xx not_active IP Right Cessation
- 1994-02-09 EP EP94906381A patent/EP0686156B1/en not_active Expired - Lifetime
- 1994-02-09 CA CA002156919A patent/CA2156919A1/en not_active Abandoned
- 1994-02-09 WO PCT/JP1994/000213 patent/WO1994019350A1/en active IP Right Grant
- 1994-02-09 DK DK94906381T patent/DK0686156T3/da active
- 1994-02-09 JP JP51881094A patent/JP3569917B2/ja not_active Expired - Fee Related
- 1994-02-09 RU RU95117872A patent/RU2124517C1/ru active
- 1994-02-09 KR KR1019950703609A patent/KR100313615B1/ko not_active IP Right Cessation
- 1994-02-09 AT AT94906381T patent/ATE220677T1/de not_active IP Right Cessation
- 1994-02-09 AU AU60108/94A patent/AU681625B2/en not_active Ceased
- 1994-02-09 US US08/505,284 patent/US5670503A/en not_active Expired - Fee Related
- 1994-02-09 ES ES94906381T patent/ES2176235T3/es not_active Expired - Lifetime
- 1994-02-09 HU HU9402459A patent/HUT70832A/hu unknown
- 1994-02-09 DE DE69430988T patent/DE69430988T2/de not_active Expired - Fee Related
- 1994-02-09 CN CN94191768A patent/CN1041929C/zh not_active Expired - Fee Related
- 1994-02-09 PT PT94906381T patent/PT686156E/pt unknown
- 1994-02-18 TW TW083101366A patent/TW260669B/zh active
- 1994-02-24 MX MX9401408A patent/MX9401408A/es not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US5670503A (en) | 1997-09-23 |
| DE69430988D1 (de) | 2002-08-22 |
| AU6010894A (en) | 1994-09-14 |
| AU681625B2 (en) | 1997-09-04 |
| EP0686156A1 (en) | 1995-12-13 |
| DK0686156T3 (da) | 2002-11-11 |
| TW260669B (es) | 1995-10-21 |
| CN1120840A (zh) | 1996-04-17 |
| ZA94787B (en) | 1994-09-08 |
| HUT70832A (en) | 1995-11-28 |
| IL108562A (en) | 1997-06-10 |
| KR100313615B1 (ko) | 2002-05-30 |
| IL108562A0 (en) | 1994-05-30 |
| CN1041929C (zh) | 1999-02-03 |
| JP3569917B2 (ja) | 2004-09-29 |
| JPH08507056A (ja) | 1996-07-30 |
| DE69430988T2 (de) | 2002-11-28 |
| ATE220677T1 (de) | 2002-08-15 |
| KR960701055A (ko) | 1996-02-24 |
| HU9402459D0 (en) | 1994-11-28 |
| EP0686156B1 (en) | 2002-07-17 |
| GB9303993D0 (en) | 1993-04-14 |
| WO1994019350A1 (en) | 1994-09-01 |
| PT686156E (pt) | 2002-12-31 |
| CA2156919A1 (en) | 1994-09-01 |
| RU2124517C1 (ru) | 1999-01-10 |
| ES2176235T3 (es) | 2002-12-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration | ||
| MM | Annulment or lapse due to non-payment of fees |