MX9308199A - ENZYME INHIBITORS. - Google Patents

ENZYME INHIBITORS.

Info

Publication number
MX9308199A
MX9308199A MX9308199A MX9308199A MX9308199A MX 9308199 A MX9308199 A MX 9308199A MX 9308199 A MX9308199 A MX 9308199A MX 9308199 A MX9308199 A MX 9308199A MX 9308199 A MX9308199 A MX 9308199A
Authority
MX
Mexico
Prior art keywords
synthase
enzyme inhibitors
tetrahydrobiopterin
endothelial
binds
Prior art date
Application number
MX9308199A
Other languages
Spanish (es)
Inventor
Eric Cleveland Bigham
John Frederick Reinhard Jr
Philip Keith Moore
Rachel Cecilia Babbedge
Richard Graham Knowles
Malcolm Stuart Nobbs
Donald Bull
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929226377A external-priority patent/GB9226377D0/en
Priority claimed from GB939303221A external-priority patent/GB9303221D0/en
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of MX9308199A publication Critical patent/MX9308199A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

Se describe el uso de un compuesto que se une en el sitio detetrahidrobiopterina de la sintasa ON para el tratamiento de condicionesen donde hay ventaja en la inhibición de la ON-sintasa neuronal, con pocao ninguna inhibición de la ON-sintasa endotelial. También se describenformulaciones farmacéuticas que comprenden dichos compuestos y losprocedimientos, incluyendo un procedimiento novedoso, para su preparación.The use of a compound that binds to the ON synthase tetrahydrobiopterin site is described for the treatment of conditions where there is an advantage in inhibiting neuronal ON synthase, with little or no endothelial ON synthase inhibition. Pharmaceutical formulations comprising said compounds and the procedures, including a novel procedure, for their preparation are also described.

MX9308199A 1992-12-18 1993-12-17 ENZYME INHIBITORS. MX9308199A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929226377A GB9226377D0 (en) 1992-12-18 1992-12-18 Pharmaceutical compositions
GB939303221A GB9303221D0 (en) 1993-02-18 1993-02-18 Nitric oxide synthase inhibitors

Publications (1)

Publication Number Publication Date
MX9308199A true MX9308199A (en) 1995-01-31

Family

ID=26302179

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9308199A MX9308199A (en) 1992-12-18 1993-12-17 ENZYME INHIBITORS.

Country Status (6)

Country Link
EP (1) EP0674627A1 (en)
JP (1) JPH08504798A (en)
AU (1) AU5704594A (en)
IL (1) IL108075A0 (en)
MX (1) MX9308199A (en)
WO (1) WO1994014780A1 (en)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2136661C1 (en) * 1993-10-21 1999-09-10 Джи Ди Сирл энд Ко. Amidino-derivatives, their use and pharmaceutical composition
WO1995024382A1 (en) * 1994-03-10 1995-09-14 G.D. Searle & Co. L-n6-(1-iminoethyl)lysine derivatives useful as nitric oxide synthase inhibitors
DE4418097A1 (en) * 1994-05-24 1995-11-30 Cassella Ag Use of tetrahydropteridine derivatives as inhibitors of NO synthase
DE4418096A1 (en) * 1994-05-24 1995-11-30 Cassella Ag Use of pteridine derivatives as inhibitors of NO synthase
US5684008A (en) 1994-11-09 1997-11-04 G. D. Searle & Co. Aminotetrazole derivatives useful as nitric oxide synthase inhibitors
WO1996018617A1 (en) * 1994-12-12 1996-06-20 Merck & Co., Inc. Substituted 2-acylamino-pyridines as inhibitors of nitric oxide synthase
WO1996018616A1 (en) * 1994-12-12 1996-06-20 Merck & Co., Inc. Substituted 2-aminopyridines as inhibitors of nitric oxide synthase
WO1996033175A1 (en) * 1995-04-20 1996-10-24 G.D. Searle & Co. Cyclic amidino agents useful as nitric oxide synthase inhibitors
US5830917A (en) * 1995-09-11 1998-11-03 G. D. Searle & Co. L-N6 -(1-iminoethyl) lysine derivatives useful as nitric oxide synthase inhibitors
US5908842A (en) * 1995-12-08 1999-06-01 Merck & Co., Inc. Substituted 2-acylamino-pyridines as inhibitors of nitric oxide synthase
US5981511A (en) * 1996-03-06 1999-11-09 G.D. Searle & Co. Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors
US5945408A (en) * 1996-03-06 1999-08-31 G.D. Searle & Co. Hydroxyanidino derivatives useful as nitric oxide synthase inhibitors
FR2745812B1 (en) * 1996-03-08 1998-05-07 Hoechst Lab DIBENZO (C, F) AZONINES, PROCESSES FOR THEIR PREPARATION AND THEIR APPLICATIONS
PT891332E (en) * 1996-03-29 2004-07-30 Pfizer 6-PHENYLPYRIDYL-2-AMINE DERIVATIVES
HN1997000027A (en) * 1996-12-06 1997-06-05 Pfizer Prod Inc DERIVATIVES OF 6-PHENYL PIRIDIL - 2 AMINE
US6160000A (en) * 1996-12-23 2000-12-12 Merck & Co., Inc. Antidiabetic agents based on aryl and heteroarylacetic acids
US6090839A (en) * 1996-12-23 2000-07-18 Merck & Co., Inc. Antidiabetic agents
BR9811093A (en) * 1997-02-10 2000-07-18 Pfizer Prod Inc Pyridines replaced with 2-amino-6- (2-substituted 4-phenoxy)
US5981556A (en) * 1997-07-22 1999-11-09 G.D. Searle & Co. 1,3-diazolino and 1,3-diazolidino heterocycles as useful nitric oxide synthase inhibitors
US20010049379A1 (en) 1997-08-27 2001-12-06 Lowe John Adams 2-aminopyridines containing fused ring substituents
US6440965B1 (en) 1997-10-15 2002-08-27 Krenitsky Pharmaceuticals, Inc. Substituted pyrimidine derivatives, their preparation and their use in the treatment of neurodegenerative or neurological disorders of the central nervous system
GB9726987D0 (en) 1997-12-22 1998-02-18 Glaxo Group Ltd Compounds
US6552052B2 (en) 1998-06-10 2003-04-22 Monsanto/G.D. Searle Pyrrolo[2,1-c][1,2,4] thiadiazoles and Pyrollo[2,1-c][1,12,4]oxadiazoles useful as nitric oxide synthase inhibitors
US6489323B1 (en) 1998-06-10 2002-12-03 G.D. Searle & Co. Heterobicyclic and tricyclic nitric oxide synthase inhibitors
FR2784678B1 (en) * 1998-09-23 2002-11-29 Sod Conseils Rech Applic NOVEL N- (IMINOMETHYL) AMINE DERIVATIVES, THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US6583148B1 (en) 1999-04-08 2003-06-24 Krenitsky Pharmaceuticals, Inc. Neurotrophic substituted pyrimidines
DE19944767A1 (en) 1999-09-17 2001-03-29 Vasopharm Biotech Gmbh & Co Kg N-substituted 4-aminopteridines, process for their preparation and their use as medicines
YU54202A (en) 2000-01-18 2006-01-16 Agouron Pharmaceuticals Inc. Indazole compounds,pharmaceutical compositions,and methods for mediating or inhibiting cell proliferation
HN2001000008A (en) 2000-01-21 2003-12-11 Inc Agouron Pharmaceuticals AMIDA COMPOSITE AND PHARMACEUTICAL COMPOSITIONS TO INHIBIT PROTEINKINASES, AND THE INSTRUCTIONS FOR USE
AU2001247745B2 (en) 2000-03-24 2006-08-31 Pharmacia Corporation Amidino compounds useful as nitric oxide synthase inhibitors
AR032318A1 (en) 2000-04-13 2003-11-05 Pharmacia Corp HALOGENATED DERIVATIVE COMPOUND OF HEPTENOIC ACID 2-AMINO-5,6; PHARMACEUTICAL COMPOSITION THAT INCLUDES IT AND ITS USE IN THE MANUFACTURE OF A USEFUL MEDICINAL PRODUCT AS AN INHIBITOR OF NITRICAL SYNTHEASE OXIDE
US6787668B2 (en) 2000-04-13 2004-09-07 Pharmacia Corporation 2-amino-4,5 heptenoic acid derivatives useful as nitric oxide synthase inhibitors
US6956131B2 (en) 2000-04-13 2005-10-18 Pharmacia Corporation 2-amino-3, 4 heptenoic compounds useful as nitric oxide synthase inhibitors
US6545170B2 (en) 2000-04-13 2003-04-08 Pharmacia Corporation 2-amino-5, 6 heptenoic acid derivatives useful as nitric oxide synthase inhibitors
AR030416A1 (en) 2000-04-13 2003-08-20 Pharmacia Corp HALOGENATED DERIVATIVE COMPOUND OF HEPTENOIC ACID 2-AMINO-3,4, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT AND ITS USE IN THE MANUFACTURE OF A USEFUL MEDICINAL PRODUCT AS AN INHIBITOR OF SYNTHETIC NITRIC OXIDE
AR034120A1 (en) 2000-04-13 2004-02-04 Pharmacia Corp HALOGENATED DERIVATIVE COMPOUND OF HEPTENOIC ACID 2-AMINO-4,5, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT AND THE USE OF SUCH COMPOUND AND SUCH COMPOSITION IN THE MANUFACTURE OF A MEDICINAL PRODUCT TO INHIBIT OR MODULATE NITRIC ACID SYNTHESIS
WO2001079198A1 (en) 2000-04-18 2001-10-25 Agouron Pharmaceuticals, Inc. Pyrazoles for inhibiting protein kinase
US7205297B2 (en) 2000-07-24 2007-04-17 Krenitsky Pharmaceuticals, Inc. Substituted 5-alkynyl pyrimidines having neurotrophic activity
US6344473B1 (en) 2000-08-07 2002-02-05 G.D. Searle & Co. Imidazoles useful as nitric oxide synthase inhibitors
KR100406634B1 (en) * 2001-03-12 2003-11-20 주식회사 엘지생명과학 3,5-Diaminoindazole derivatives, their preparation and their use as inhibitors for cyclin dependent kinases
US7012098B2 (en) 2001-03-23 2006-03-14 Pharmacia Corporation Inhibitors of inducible nitric oxide synthase for chemoprevention and treatment of cancers
WO2005037286A1 (en) * 2003-03-25 2005-04-28 Vasopharm Biotech Gmbh Use of pteridine derivatives for the treatment of increased intracranial pressure and secondary ischemia
US7776869B2 (en) * 2004-10-18 2010-08-17 Amgen Inc. Heteroaryl-substituted alkyne compounds and method of use
AU2006264966B2 (en) 2005-07-04 2013-02-21 High Point Pharmaceuticals, Llc Histamine H3 receptor antagonists
CA2659570C (en) 2006-05-29 2015-10-06 High Point Pharmaceuticals, Llc 3-(1,3-benzodioxol-5-yl)-6-(4-cyclopropylpiperazin-1-yl)-pyridazine, its salts and solvates and its use as histamine h3 receptor antagonist
TW200901975A (en) 2007-03-05 2009-01-16 Kyowa Hakko Kogyo Kk Pharmaceutical composition
CN101675040A (en) 2007-05-03 2010-03-17 辉瑞有限公司 Pyridine derivatives
EP2014656A3 (en) 2007-06-11 2011-08-24 High Point Pharmaceuticals, LLC New heteocyclic h3 antagonists
PL2323992T3 (en) 2008-07-29 2017-01-31 Boehringer Ingelheim International Gmbh 5-alkynyl-pyrimidines
UY33198A (en) 2010-01-26 2011-08-31 Boehringer Ingelheim Int 5-ALQUINIL-PYRIMIDINS.
US8633183B2 (en) 2010-01-26 2014-01-21 Boehringer Ingelheim International Gmbh 5-alkynyl-pyrimidines
FR2978966B1 (en) 2011-08-12 2013-09-27 Schneider Electric Ind Sas FLAME RETARDANT MATERIAL COMPRISING A BIOPOLYMER.
CN103804312B (en) * 2014-02-17 2016-04-20 四川百利药业有限责任公司 Aza cyclic cpds and its production and use
CN111683660A (en) * 2018-02-05 2020-09-18 斯特拉斯堡大学 Compounds and compositions for the treatment of pain
JP2022543460A (en) 2019-08-06 2022-10-12 ドメイン・セラピューティクス 5-heteroaryl-pyridin-2-amine compounds as neuropeptide FF receptor antagonists
GB202006076D0 (en) * 2020-04-24 2020-06-10 Univ Greenwich Interleukin inhibitors
US20220289686A1 (en) * 2021-03-09 2022-09-15 Washington University Compositions of nrf2 inhibiting agents and methods of use thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE518622A (en) *
FR7631M (en) * 1968-08-13 1970-01-26
US3843678A (en) * 1971-03-15 1974-10-22 Tenneco Chem Process for the production of substituted indazoles
FR2265739B1 (en) * 1974-03-29 1976-12-17 Ugine Kuhlmann
US3988347A (en) * 1974-09-09 1976-10-26 Tenneco Chemicals, Inc. Process for the preparation of substituted indazoles
DE3378634D1 (en) * 1982-09-20 1989-01-12 Wellcome Found Pharmaceutically active pteridine derivatives
WO1988004293A1 (en) * 1986-12-02 1988-06-16 Malcolm Francis Graham Stevens Antifolate agents
FI895821A0 (en) * 1988-12-07 1989-12-05 Wellcome Found PHARMACEUTICAL ACTIVE CNS FOERENINGAR.
GB9012311D0 (en) * 1990-06-01 1990-07-18 Wellcome Found Pharmacologically active cns compounds
GB9012316D0 (en) * 1990-06-01 1990-07-18 Wellcome Found Pharmacologically active cns compounds

Also Published As

Publication number Publication date
JPH08504798A (en) 1996-05-21
IL108075A0 (en) 1994-04-12
EP0674627A1 (en) 1995-10-04
AU5704594A (en) 1994-07-19
WO1994014780A1 (en) 1994-07-07

Similar Documents

Publication Publication Date Title
MX9308199A (en) ENZYME INHIBITORS.
UY24799A1 (en) 6-PHENYLPIRIDYL-2-AMINE DERIVATIVES
ES2124793T3 (en) DERIVATIVES OF RAPAMICINA RENTED IN OR AND ITS USE, PARTICULARLY AS IMMUNOSUPRESORES.
BR9805544C1 (en) Use of a compound.
BR0312464A (en) Tyrosine kinase inhibitors
UY25322A1 (en) THIOUREA AND BENZAMIDE COMPOUNDS, COMPOSITIONS AND METHODS TO TREAT AND PREVENT INFLAMMATORY DISEASES AND ATEROSCLEROSIS
BR0212042A (en) Compound, pharmaceutical composition, method of treating or preventing disease, and use of a compound
BR0108396A (en) Pyrimidine-4-0na derivatives as ldl-pla inhibitors (2)
TR200201505T2 (en) Pirazolopyrimidines as therapeutic agents
BR9811099A (en) Urokinase inhibitors
DK0735868T3 (en) Use of non-steroidal cyclooxygenase inhibitors for the manufacture of a medicament for the treatment of elevated intracellular
ES2196190T3 (en) INHIBITORS OF METALOPROTEINASAS MATRICIALES, WITH BIFENLICO HYDROXAMATE.
DE69725860D1 (en) PLAN FOR ADMINISTRATION OF H +, K + -ATPase INHIBITORS
MX9307011A (en) WATER SOLUBLE DERIVATIVES OF CAMPTOTECINE, PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.
DK599789D0 (en) 3,5-DI-TERTIAER-BUTYL-4-HYDROXYPHENYL-1,3,4-THIADAZOLES AND OXADIAZOLES, AND 3,5-DI-TERTIAER-BUTYL-4-HYDROXYPHENYL-1,2,4-THIADAZOLES, OXADIAZOLES AND -TRIAZOLES AS ANTI-INFLAMMATORY AGENTS
DE69034070D1 (en) Racemic huperzine A
FI951298A0 (en) 2-Amino-4-phenyl-4-oxobutyric acid derivatives having kynureninase and / or kynurenine-3-hydroxylase inhibitory activity
BR0315662A (en) 1- (4-Benzyl-piperazin-1-yl) -3-phenyl-propenone derivatives
ES2187738T3 (en) DERIVATIVES OF FLAVONAS, ITS PREPARATION PROCEDURE AND THE PHARMACEUTICAL COMPOUNDS THAT CONTAIN THEM.
GR3029370T3 (en) Compounds and methods for inhibition of hiv and related viruses
DE69720996D1 (en) NEW PHARMACEUTICAL COMPOSITIONS OF STEROID NITRATE ESTER FOR USE AS AN INFLAMMATORY INHIBITOR
PT880520E (en) DERIVATIVES OF BENZOICHINOLIZIN ITS PREPARATION AND USE AS 5-ALPHA-REDUCTASE INHIBITORS
YU6396A (en) Combination of hiv protease inhibitor with other compounds for hiv infection treatment
DE69412612D1 (en) DESOXYAZAPHOSPHOLIPID DERIVATIVES WITH INHIBITING ACTIVITY ON PHOSPHOLIPASE
HN1997000070A (en) INHIBITION OF MATRIX METALOPROTEINASES BY ACIDS 2 - ((1) -AROYLALKYL) -4-BIARYL-4-OXOBURITICS