MX9301817A - POLYMERIC SYSTEM CONTAINING A PARTIALLY SOLUBLE COMPOUND. - Google Patents

POLYMERIC SYSTEM CONTAINING A PARTIALLY SOLUBLE COMPOUND.

Info

Publication number
MX9301817A
MX9301817A MX9301817A MX9301817A MX9301817A MX 9301817 A MX9301817 A MX 9301817A MX 9301817 A MX9301817 A MX 9301817A MX 9301817 A MX9301817 A MX 9301817A MX 9301817 A MX9301817 A MX 9301817A
Authority
MX
Mexico
Prior art keywords
polymer
compound
partially soluble
partially
soluble compound
Prior art date
Application number
MX9301817A
Other languages
Spanish (es)
Inventor
Wouter Erik Roorda
Fred Ehnow
Susan M Marks
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of MX9301817A publication Critical patent/MX9301817A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/20—Compounding polymers with additives, e.g. colouring
    • C08J3/203—Solid polymers with solid and/or liquid additives

Abstract

La presente invención se dirige a un método de dos pasos para incorporar un compuesto parcialmente soluble a una matriz polimérica. El método de la invención comprende los pasos de: (1) mezclar una primera porción de un compuesto parcialmente en su fase soluble a un polímero a una concentración cerca o igual a la solubilidad de equilibrio del compuesto en el polímero para dar una sola fase homogénea seguido por (2) mezclar una segunda porción del compuesto parcialmente soluble en su fase al polímero de una manera que el compuesto no se disuelve en el polímero ya que es dispersado a través del polímero y el tamaño o distribución del tamaño de las partículas se controla. La invención se dirige además a un compuesto/composiciones poliméricas preparadas durante el procedimiento anterior, para suministrar dispositivos compuestos de tales composiciones, y a un método para suministrar a un ambiente de uso un agente activo parcialmente soluble a partir de una matriz polimérica, y dicho método comprende colocar un dispositivo de suministro apropiadamente dimensionado y configurado de la invención en el ambiente de uso.The present invention is directed to a two-step method of incorporating a partially soluble compound into a polymer matrix. The method of the invention comprises the steps of: (1) mixing a first portion of a compound partially in its soluble phase to a polymer at a concentration close to or equal to the equilibrium solubility of the compound in the polymer to give a single homogeneous phase followed by (2) mixing a second portion of the phase partially soluble compound to the polymer in a way that the compound does not dissolve in the polymer as it is dispersed through the polymer and the size or particle size distribution is controlled . The invention is further directed to a polymeric compound / compositions prepared during the above process, for supplying devices composed of such compositions, and to a method of supplying a partially soluble active agent from a polymeric matrix to an environment of use, and said method it comprises placing a properly sized and configured delivery device of the invention in the environment of use.

MX9301817A 1992-03-30 1993-03-30 POLYMERIC SYSTEM CONTAINING A PARTIALLY SOLUBLE COMPOUND. MX9301817A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US86063092A 1992-03-30 1992-03-30

Publications (1)

Publication Number Publication Date
MX9301817A true MX9301817A (en) 1994-01-31

Family

ID=25333639

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9301817A MX9301817A (en) 1992-03-30 1993-03-30 POLYMERIC SYSTEM CONTAINING A PARTIALLY SOLUBLE COMPOUND.

Country Status (4)

Country Link
AU (1) AU3970993A (en)
MX (1) MX9301817A (en)
WO (1) WO1993020138A2 (en)
ZA (1) ZA932268B (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5700485A (en) 1992-09-10 1997-12-23 Children's Medical Center Corporation Prolonged nerve blockade by the combination of local anesthetic and glucocorticoid
US5618563A (en) * 1992-09-10 1997-04-08 Children's Medical Center Corporation Biodegradable polymer matrices for sustained delivery of local anesthetic agents
DE69511418T2 (en) 1995-10-28 2000-03-30 Braun Melsungen Ag Pharmaceutical compositions containing local anesthetics and / or central analgesics
DE19710009A1 (en) * 1997-03-12 1998-09-24 Knoll Ag Multi-phase preparation forms containing active ingredients
WO1999000013A2 (en) 1997-06-30 1999-01-07 Monsanto Company Microparticles containing agricultural active ingredients
US6787157B1 (en) 1998-03-10 2004-09-07 Abbott Laboratories Multiphase active ingredient-containing formulations
DE10026698A1 (en) 2000-05-30 2001-12-06 Basf Ag Self-emulsifying active ingredient formulation and use of this formulation
DE10207394B4 (en) * 2002-02-21 2007-03-29 Lts Lohmann Therapie-Systeme Ag Taste-masked oblate medicinal preparation
FR2846557B1 (en) * 2002-10-30 2007-06-08 Statice Sante IMPLANTABLE STRUCTURE FOR PROLONGED AND CONTROLLED RELEASE OF AN ACTIVE INGREDIENT
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
US8377952B2 (en) 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
EP1690528A1 (en) 2005-02-11 2006-08-16 Abbott GmbH & Co. KG Process for the preparation of dosage forms comprising a solid dispersion of a microcrystalline active agent
EP3658123A4 (en) 2017-07-24 2021-04-28 Acryspharm LLC High drug loading pharmaceutical compositions

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4093709A (en) * 1975-01-28 1978-06-06 Alza Corporation Drug delivery devices manufactured from poly(orthoesters) and poly(orthocarbonates)
EP0156080B2 (en) * 1984-03-05 1993-10-20 Nitto Denko Corporation Percutaneous absorption type adhesive pharmaceutical preparation
JP2849950B2 (en) * 1990-11-30 1999-01-27 日東電工株式会社 Transdermal formulation

Also Published As

Publication number Publication date
AU3970993A (en) 1993-11-08
ZA932268B (en) 1993-11-11
WO1993020138A3 (en) 1994-02-17
WO1993020138A2 (en) 1993-10-14

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