MX9300482A - PROCESS FOR THE PREPARATION OF 2-AMINO-6-CHLOROPURINE. - Google Patents

PROCESS FOR THE PREPARATION OF 2-AMINO-6-CHLOROPURINE.

Info

Publication number
MX9300482A
MX9300482A MX9300482A MX9300482A MX9300482A MX 9300482 A MX9300482 A MX 9300482A MX 9300482 A MX9300482 A MX 9300482A MX 9300482 A MX9300482 A MX 9300482A MX 9300482 A MX9300482 A MX 9300482A
Authority
MX
Mexico
Prior art keywords
chloropurine
amino
preparation
acyl group
diacylated
Prior art date
Application number
MX9300482A
Other languages
Spanish (es)
Inventor
Christopher Robert Jame Killen
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of MX9300482A publication Critical patent/MX9300482A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Se describe un proceso para la preparación de 2-amino-6-cloropurina que comprende la reacción de un derivado 2,9-diacilado de guanina con un agente de cloración, en presencia de un catalizador de transferencia de fase que contienen iones cloruro y después de esto la eliminación del grupo 9-acilo y el grupo 2-acilo mediante hidrólisis.A process for the preparation of 2-amino-6-chloropurine is described which comprises the reaction of a 2,9-diacylated guanine derivative with a chlorinating agent, in the presence of a phase transfer catalyst containing chloride ions and then hence the removal of the 9-acyl group and the 2-acyl group by hydrolysis.

MX9300482A 1992-01-30 1993-01-28 PROCESS FOR THE PREPARATION OF 2-AMINO-6-CHLOROPURINE. MX9300482A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929201961A GB9201961D0 (en) 1992-01-30 1992-01-30 Pharmaceuticals

Publications (1)

Publication Number Publication Date
MX9300482A true MX9300482A (en) 1994-07-29

Family

ID=10709516

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9300482A MX9300482A (en) 1992-01-30 1993-01-28 PROCESS FOR THE PREPARATION OF 2-AMINO-6-CHLOROPURINE.

Country Status (10)

Country Link
EP (1) EP0625154A1 (en)
JP (1) JPH07503246A (en)
KR (1) KR950700299A (en)
AU (1) AU669874B2 (en)
CA (1) CA2117435A1 (en)
GB (1) GB9201961D0 (en)
MX (1) MX9300482A (en)
NZ (1) NZ246677A (en)
WO (1) WO1993015075A1 (en)
ZA (1) ZA93615B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4231036A1 (en) * 1992-09-17 1994-03-24 Basf Ag Process for the preparation of 2-amino-6-halopurines
JPH07133276A (en) * 1993-09-17 1995-05-23 Jiyuuzen Kagaku Kk Production of 2-acetylamono-6-chloropurine
DE4415196C1 (en) * 1994-04-30 1995-04-27 Boehringer Ingelheim Kg Improved process for the preparation of 2-amino-6-chloropurine and 2-acylamino-6-chloropurines
US5789590A (en) * 1995-11-09 1998-08-04 Sumika Fine Chemicals Co., Ltd. Double cone-like crystal form of 2-amino-6-chloropurine and preparation
ES2292998T3 (en) * 2002-04-04 2008-03-16 Sumitomo Chemical Company, Limited PRODUCTION METHOD OF 2,6-DIHALOPURIN.
CN102336755B (en) * 2011-09-30 2013-03-27 浙江工业大学 Chemical synthesis method of 6-chloropurine
CN113214260B (en) * 2021-05-10 2022-04-01 上海凌凯医药科技有限公司 Synthesis method of 2-acetamido-9-acetyl purine

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3485225D1 (en) 1983-08-18 1991-12-05 Beecham Group Plc ANTIVIRAL GUANINE DERIVATIVES.
EP0182024B1 (en) 1984-09-20 1991-04-03 Beecham Group Plc Purine derivatives and their pharmaceutical use
GB8507606D0 (en) * 1985-03-23 1985-05-01 Beecham Group Plc Process
DE3941658A1 (en) * 1989-12-16 1991-06-20 Hoechst Ag METHOD FOR PRODUCING 2-ACYLAMINO-9-ACYL-6-HALOGEN PURIN
DE3941657A1 (en) * 1989-12-16 1991-06-20 Hoechst Ag METHOD FOR PRODUCING 2-ACYLAMINO-6-HALOGEN PURINE FROM 2,9-DIACYLGUANINE
GB9102127D0 (en) * 1991-01-31 1991-03-13 Smithkline Beecham Plc Pharmaceuticals

Also Published As

Publication number Publication date
CA2117435A1 (en) 1993-08-05
KR950700299A (en) 1995-01-16
AU3365493A (en) 1993-09-01
AU669874B2 (en) 1996-06-27
ZA93615B (en) 1993-11-26
JPH07503246A (en) 1995-04-06
NZ246677A (en) 1996-02-27
EP0625154A1 (en) 1994-11-23
WO1993015075A1 (en) 1993-08-05
GB9201961D0 (en) 1992-03-18

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