MX9204258A - Sintesis asimetrica de la cadena lateral de taxol. - Google Patents
Sintesis asimetrica de la cadena lateral de taxol.Info
- Publication number
- MX9204258A MX9204258A MX9204258A MX9204258A MX9204258A MX 9204258 A MX9204258 A MX 9204258A MX 9204258 A MX9204258 A MX 9204258A MX 9204258 A MX9204258 A MX 9204258A MX 9204258 A MX9204258 A MX 9204258A
- Authority
- MX
- Mexico
- Prior art keywords
- taxol
- side chain
- asymmetric synthesis
- asymmetric
- synthesis
- Prior art date
Links
- 229930012538 Paclitaxel Natural products 0.000 title 1
- 238000011914 asymmetric synthesis Methods 0.000 title 1
- 229960001592 paclitaxel Drugs 0.000 title 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1896—Compounds having one or more Si-O-acyl linkages
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Epoxy Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73901891A | 1991-07-31 | 1991-07-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX9204258A true MX9204258A (es) | 1993-03-01 |
Family
ID=24970469
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX9204258A MX9204258A (es) | 1991-07-31 | 1992-07-21 | Sintesis asimetrica de la cadena lateral de taxol. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5300638A (es) |
| EP (1) | EP0525589A1 (es) |
| JP (1) | JPH05201969A (es) |
| KR (1) | KR930002312A (es) |
| CN (1) | CN1069028A (es) |
| AU (1) | AU2064092A (es) |
| CA (1) | CA2071160A1 (es) |
| CZ (1) | CZ227592A3 (es) |
| FI (1) | FI923309A (es) |
| HU (1) | HU9202371D0 (es) |
| IE (1) | IE922353A1 (es) |
| IL (1) | IL102586A0 (es) |
| MX (1) | MX9204258A (es) |
| NO (1) | NO922863L (es) |
| PL (1) | PL295148A1 (es) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69329304T2 (de) * | 1992-01-15 | 2001-01-04 | E.R. Squibb & Sons, Inc. | Enzymatische Verfahren zur Resolution von Enantiomeren-Mischungen nützlich wie Zwischenprodukte zur Herstellung von Taxanen |
| FR2703994B1 (fr) * | 1993-04-16 | 1995-05-24 | Rhone Poulenc Rorer Sa | Procédé de préparation de beta-lactames. |
| US5939561A (en) * | 1992-03-10 | 1999-08-17 | Rhone-Poulence Rorer S.A. | Process for the preparation of β-phenylisoserine and β-lactam and their analogues |
| US5478854A (en) * | 1992-10-01 | 1995-12-26 | Bristol-Myers Squibb Company | Deoxy taxols |
| ZA94128B (en) * | 1993-02-01 | 1994-08-19 | Univ New York State Res Found | Process for the preparation of taxane derivatives and betalactam intermediates therefor |
| US5684175A (en) * | 1993-02-05 | 1997-11-04 | Napro Biotherapeutics, Inc. | C-2' hydroxyl-benzyl protected, N-carbamate protected (2R, 3S)- 3-phenylisoserine and production process therefor |
| TW397866B (en) | 1993-07-14 | 2000-07-11 | Bristol Myers Squibb Co | Enzymatic processes for the resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes |
| AU716005B2 (en) * | 1995-06-07 | 2000-02-17 | Cook Medical Technologies Llc | Implantable medical device |
| US5807888A (en) * | 1995-12-13 | 1998-09-15 | Xechem International, Inc. | Preparation of brominated paclitaxel analogues and their use as effective antitumor agents |
| US5654448A (en) * | 1995-10-02 | 1997-08-05 | Xechem International, Inc. | Isolation and purification of paclitaxel from organic matter containing paclitaxel, cephalomannine and other related taxanes |
| US5840748A (en) * | 1995-10-02 | 1998-11-24 | Xechem International, Inc. | Dihalocephalomannine and methods of use therefor |
| US5854278A (en) * | 1995-12-13 | 1998-12-29 | Xechem International, Inc. | Preparation of chlorinated paclitaxel analogues and use thereof as antitumor agents |
| US6177456B1 (en) | 1995-10-02 | 2001-01-23 | Xechem International, Inc. | Monohalocephalomannines having anticancer and antileukemic activity and method of preparation therefor |
| EP1019347B1 (en) | 1997-08-21 | 2003-03-19 | Florida State University | Method for the synthesis of taxanes |
| US5917062A (en) * | 1997-11-21 | 1999-06-29 | Indena S.P.A | Intermediates and methods useful in the semisynthesis of paclitaxel and analogs |
| US6150537A (en) * | 1997-12-12 | 2000-11-21 | Emory University | Methods for the esterification of alcohols and compounds useful therefor as potential anticancer agents |
| CA2440935A1 (en) * | 2001-03-13 | 2002-09-19 | Richard Liggins | Micellar drug delivery vehicles and precursors thereto and uses thereof |
| US20030157170A1 (en) * | 2001-03-13 | 2003-08-21 | Richard Liggins | Micellar drug delivery vehicles and precursors thereto and uses thereof |
| ES2286244T3 (es) * | 2001-04-20 | 2007-12-01 | The University Of British Columbia | Sistemas de suministro de farmaco micelar para farmacos hirofobicos. |
| AU2002365883A1 (en) * | 2001-11-30 | 2003-06-17 | Bristol-Myers Squibb Company | Paclitaxel solvates |
| US20030216758A1 (en) * | 2001-12-28 | 2003-11-20 | Angiotech Pharmaceuticals, Inc. | Coated surgical patches |
| EP1594459B1 (en) | 2002-12-30 | 2010-02-17 | Angiotech International Ag | Drug delivery from rapid gelling polymer composition |
| US7846940B2 (en) * | 2004-03-31 | 2010-12-07 | Cordis Corporation | Solution formulations of sirolimus and its analogs for CAD treatment |
| US8003122B2 (en) * | 2004-03-31 | 2011-08-23 | Cordis Corporation | Device for local and/or regional delivery employing liquid formulations of therapeutic agents |
| US7989490B2 (en) | 2004-06-02 | 2011-08-02 | Cordis Corporation | Injectable formulations of taxanes for cad treatment |
| US20070073385A1 (en) * | 2005-09-20 | 2007-03-29 | Cook Incorporated | Eluting, implantable medical device |
| US20070196423A1 (en) * | 2005-11-21 | 2007-08-23 | Med Institute, Inc. | Implantable medical device coatings with biodegradable elastomer and releasable therapeutic agent |
| EP2043704B2 (en) | 2006-06-30 | 2017-04-19 | Cook Medical Technologies LLC | Methods of manufacturing and modifying taxane coatings for implantable medical devices |
| US20080241215A1 (en) * | 2007-03-28 | 2008-10-02 | Robert Falotico | Local vascular delivery of probucol alone or in combination with sirolimus to treat restenosis, vulnerable plaque, aaa and stroke |
| US8409601B2 (en) | 2008-03-31 | 2013-04-02 | Cordis Corporation | Rapamycin coated expandable devices |
| US8420110B2 (en) | 2008-03-31 | 2013-04-16 | Cordis Corporation | Drug coated expandable devices |
| US8273404B2 (en) * | 2008-05-19 | 2012-09-25 | Cordis Corporation | Extraction of solvents from drug containing polymer reservoirs |
| US8642063B2 (en) * | 2008-08-22 | 2014-02-04 | Cook Medical Technologies Llc | Implantable medical device coatings with biodegradable elastomer and releasable taxane agent |
| US9198968B2 (en) | 2008-09-15 | 2015-12-01 | The Spectranetics Corporation | Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens |
| CN101838281B (zh) * | 2010-05-20 | 2015-02-18 | 上海博速医药科技有限公司 | 一种多西他赛手性侧链中间体的制备方法 |
| US20120303115A1 (en) | 2011-05-25 | 2012-11-29 | Dadino Ronald C | Expandable devices coated with a rapamycin composition |
| US20120302954A1 (en) | 2011-05-25 | 2012-11-29 | Zhao Jonathon Z | Expandable devices coated with a paclitaxel composition |
| US9956385B2 (en) | 2012-06-28 | 2018-05-01 | The Spectranetics Corporation | Post-processing of a medical device to control morphology and mechanical properties |
| CN108135917B (zh) | 2015-09-25 | 2021-07-09 | Zy医疗 | 基于包含多糖-维生素缀合物的颗粒的药物制剂 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4751299A (en) * | 1983-11-18 | 1988-06-14 | Takeda Chemical Industries, Ltd. | Optically active β-lactams and method of their production |
| JPS62209079A (ja) * | 1986-03-11 | 1987-09-14 | Sanraku Inc | 二置換アミノカルバペナム類 |
| FR2629818B1 (fr) * | 1988-04-06 | 1990-11-16 | Centre Nat Rech Scient | Procede de preparation du taxol |
| US5175315A (en) * | 1989-05-31 | 1992-12-29 | Florida State University | Method for preparation of taxol using β-lactam |
| US5136060A (en) * | 1989-11-14 | 1992-08-04 | Florida State University | Method for preparation of taxol using an oxazinone |
-
1992
- 1992-06-12 CA CA002071160A patent/CA2071160A1/en not_active Abandoned
- 1992-07-03 PL PL29514892A patent/PL295148A1/xx unknown
- 1992-07-16 US US07/914,909 patent/US5300638A/en not_active Expired - Fee Related
- 1992-07-20 IE IE235392A patent/IE922353A1/en not_active Application Discontinuation
- 1992-07-20 HU HU9202371A patent/HU9202371D0/hu unknown
- 1992-07-20 FI FI923309A patent/FI923309A/fi unknown
- 1992-07-20 JP JP4234026A patent/JPH05201969A/ja active Pending
- 1992-07-20 NO NO92922863A patent/NO922863L/no unknown
- 1992-07-20 CN CN92105923A patent/CN1069028A/zh active Pending
- 1992-07-21 IL IL102586A patent/IL102586A0/xx unknown
- 1992-07-21 EP EP92112442A patent/EP0525589A1/en not_active Ceased
- 1992-07-21 MX MX9204258A patent/MX9204258A/es unknown
- 1992-07-21 CZ CS922275A patent/CZ227592A3/cs unknown
- 1992-07-21 KR KR1019920012990A patent/KR930002312A/ko not_active Application Discontinuation
- 1992-07-30 AU AU20640/92A patent/AU2064092A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2064092A (en) | 1993-02-04 |
| FI923309A0 (fi) | 1992-07-20 |
| PL295148A1 (en) | 1993-06-14 |
| JPH05201969A (ja) | 1993-08-10 |
| US5300638A (en) | 1994-04-05 |
| HU9202371D0 (en) | 1992-10-28 |
| CZ227592A3 (en) | 1993-02-17 |
| FI923309A (fi) | 1993-02-01 |
| NO922863D0 (no) | 1992-07-20 |
| IL102586A0 (en) | 1993-01-14 |
| IE922353A1 (en) | 1993-11-03 |
| EP0525589A1 (en) | 1993-02-03 |
| NO922863L (no) | 1993-02-01 |
| CA2071160A1 (en) | 1993-02-01 |
| CN1069028A (zh) | 1993-02-17 |
| KR930002312A (ko) | 1993-02-22 |
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