MX367340B - Metodo para producir l-aminoacidos en corynebacteria utilizando un sistema de division de glicina. - Google Patents
Metodo para producir l-aminoacidos en corynebacteria utilizando un sistema de division de glicina.Info
- Publication number
- MX367340B MX367340B MX2016013953A MX2016013953A MX367340B MX 367340 B MX367340 B MX 367340B MX 2016013953 A MX2016013953 A MX 2016013953A MX 2016013953 A MX2016013953 A MX 2016013953A MX 367340 B MX367340 B MX 367340B
- Authority
- MX
- Mexico
- Prior art keywords
- corynebacteria
- producing
- amino acids
- cleavage system
- glycine cleavage
- Prior art date
Links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
- C12N9/0016—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with NAD or NADP as acceptor (1.4.1)
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- C12N9/0004—Oxidoreductases (1.)
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
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- C12N9/1014—Hydroxymethyl-, formyl-transferases (2.1.2)
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
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- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1235—Diphosphotransferases (2.7.6)
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- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
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- C12P13/00—Preparation of nitrogen-containing organic compounds
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- C12P13/00—Preparation of nitrogen-containing organic compounds
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- C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
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- C12P13/00—Preparation of nitrogen-containing organic compounds
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- C12Y104/00—Oxidoreductases acting on the CH-NH2 group of donors (1.4)
- C12Y104/04—Oxidoreductases acting on the CH-NH2 group of donors (1.4) with a disulfide as acceptor (1.4.4)
- C12Y104/04002—Glycine dehydrogenase (decarboxylating) (1.4.4.2)
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- C12Y108/00—Oxidoreductases acting on sulfur groups as donors (1.8)
- C12Y108/01—Oxidoreductases acting on sulfur groups as donors (1.8) with NAD+ or NADP+ as acceptor (1.8.1)
- C12Y108/01004—Dihydrolipoyl dehydrogenase (1.8.1.4), i.e. lipoamide-dehydrogenase
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- C12Y201/00—Transferases transferring one-carbon groups (2.1)
- C12Y201/02—Hydroxymethyl-, formyl- and related transferases (2.1.2)
- C12Y201/0201—Aminomethyltransferase (2.1.2.10)
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- C12Y203/00—Acyltransferases (2.3)
- C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
- C12Y203/01181—Lipoyl(octanoyl) transferase (2.3.1.181)
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- C12Y203/00—Acyltransferases (2.3)
- C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
- C12Y203/01204—Octanoyl-[GcvH]:protein N-octanoyltransferase (2.3.1.204)
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- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/07—Nucleotidyltransferases (2.7.7)
- C12Y207/07063—Lipoate--protein ligase (2.7.7.63)
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- C12Y208/00—Transferases transferring sulfur-containing groups (2.8)
- C12Y208/01—Sulfurtransferases (2.8.1)
- C12Y208/01008—Lipoyl synthase (2.8.1.8)
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- Chemical & Material Sciences (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
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- Preparation Of Compounds By Using Micro-Organisms (AREA)
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Abstract
La presente invención se refiere a la cepa Corynebacterium humireducens comprende un sistema de diversión de glicina muy eficaz.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14166649.5A EP2940039A1 (de) | 2014-04-30 | 2014-04-30 | Verfahren zur Produktion von L-Aminosäuren in Corynebakterien unter Verwendung eines Glycin spaltenden Systems |
PCT/EP2015/058280 WO2015165740A2 (de) | 2014-04-30 | 2015-04-16 | Verfahren zur produktion von l-aminosäuren in corynebakterien unter verwendung eines glycin spaltenden systems |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2016013953A MX2016013953A (es) | 2016-11-09 |
MX367340B true MX367340B (es) | 2019-08-14 |
Family
ID=50677977
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016013953A MX367340B (es) | 2014-04-30 | 2015-04-16 | Metodo para producir l-aminoacidos en corynebacteria utilizando un sistema de division de glicina. |
Country Status (14)
Country | Link |
---|---|
US (1) | US20170051324A1 (es) |
EP (2) | EP2940039A1 (es) |
JP (1) | JP2017518034A (es) |
KR (1) | KR102260001B1 (es) |
CN (1) | CN106536724A (es) |
AR (1) | AR100238A1 (es) |
BR (1) | BR112016025069A2 (es) |
ES (1) | ES2705405T3 (es) |
MX (1) | MX367340B (es) |
MY (1) | MY181461A (es) |
PL (1) | PL3137492T3 (es) |
RU (1) | RU2713298C2 (es) |
SG (1) | SG11201608281RA (es) |
WO (1) | WO2015165740A2 (es) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
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CN107750273B (zh) * | 2015-03-18 | 2023-01-31 | 巴斯夫欧洲公司 | 用于改善精细化学品生产的重组微生物 |
MX2018006434A (es) | 2015-11-27 | 2018-09-28 | Evonik Degussa Gmbh | Metodo para producir l-metionina. |
CN107227283B (zh) * | 2017-05-26 | 2021-01-15 | 廊坊梅花生物技术开发有限公司 | 一种谷氨酸棒杆菌及其构建方法与应用 |
EP3456833A1 (en) | 2017-09-18 | 2019-03-20 | Evonik Degussa GmbH | Method for the fermentative production of l-amino acids |
CN109797126B (zh) * | 2017-11-17 | 2021-07-06 | 中国科学院微生物研究所 | 生产l-丝氨酸的重组菌及其构建方法 |
KR101999454B1 (ko) * | 2017-12-19 | 2019-07-11 | 씨제이제일제당 (주) | L-아르기닌을 생산하는 코리네박테리움 속 미생물 및 이를 이용한 l-아르기닌 생산방법 |
RU2019128538A (ru) | 2018-09-26 | 2021-03-11 | Эвоник Оперейшенс ГмбХ | Способ ферментативного получения l-лизина |
KR102204917B1 (ko) * | 2019-04-22 | 2021-01-20 | 씨제이제일제당 주식회사 | L-히스티딘 생산능이 강화된 미생물 및 이를 이용한 히스티딘 생산방법 |
KR102175112B1 (ko) * | 2019-04-22 | 2020-11-06 | 씨제이제일제당 주식회사 | L-쓰레오닌 생산능이 강화된 미생물 및 이를 이용한 쓰레오닌 생산방법 |
US20210352902A1 (en) * | 2020-05-15 | 2021-11-18 | Psimos, Inc. | Composition for growth stimulation and resistance to stress factors for plants of the cannabaceae family |
CN112063572B (zh) * | 2020-09-22 | 2022-07-19 | 浙江工业大学 | 一种高产o-乙酰-l-高丝氨酸的重组大肠杆菌及其应用 |
KR102281367B1 (ko) * | 2021-01-26 | 2021-07-22 | 씨제이제일제당 (주) | 신규한 5,10-메틸렌테트라하이드로폴레이트 리덕타제 변이체 및 이를 이용한 l-발린 생산 방법 |
KR102281371B1 (ko) * | 2021-04-07 | 2021-07-22 | 씨제이제일제당 (주) | 신규한 글리세르알데히드-3-인산탈수소효소 변이체 및 이를 이용한 l-발린 생산 방법 |
KR102281370B1 (ko) * | 2021-04-07 | 2021-07-22 | 씨제이제일제당 (주) | 신규한 2-이소프로필말레이트합성효소 변이체 및 이를 이용한 l-발린 생산 방법 |
WO2022231042A1 (ko) * | 2021-04-30 | 2022-11-03 | 씨제이제일제당 (주) | 신규한 변이체 및 이를 이용한 l-발린 생산 방법 |
WO2023166027A1 (en) * | 2022-03-01 | 2023-09-07 | Metabolic Explorer | Microorganism and method for the improved production of leucine and/or isoleucine |
KR102636674B1 (ko) * | 2022-07-11 | 2024-02-15 | 대상 주식회사 | L-글루탐산을 생산하는 코리네박테리움 속 변이 미생물 및 이를 이용한 l-글루탐산의 생산 방법 |
KR20240086806A (ko) * | 2022-12-08 | 2024-06-19 | 씨제이제일제당 (주) | 퓨린 뉴클레오티드를 생산하는 미생물 및 이를 이용한 퓨린 뉴클레오티드의 생산방법 |
KR20240105550A (ko) * | 2022-12-28 | 2024-07-08 | 씨제이제일제당 (주) | 신규한 아세토락테이트 합성효소 활성을 갖는 변이체 폴리펩티드 및 이를 이용한 l-글루탐산 생산 방법 |
KR20240108884A (ko) * | 2022-12-30 | 2024-07-10 | 씨제이제일제당 (주) | 신규한 bbd29_rs02010 변이체 및 이를 이용한 l-아르기닌 생산 방법 |
WO2024144382A1 (ko) * | 2022-12-30 | 2024-07-04 | 씨제이제일제당 (주) | 신규한 bbd29_rs14450 변이체 및 이를 이용한 l-아르기닌 생산 방법 |
CN117512029B (zh) * | 2024-01-03 | 2024-03-29 | 地奥集团成都药业股份有限公司 | 一种提升谷氨酰胺产量的培养基、方法及代谢组学分析方法 |
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GB1342308A (en) | 1970-01-22 | 1974-01-03 | Kyowa Hakko Kogyo Kk | Production of threonine and lysine by fermentation |
US5250434A (en) | 1987-03-27 | 1993-10-05 | Ajinomoto Co., Inc. | Microorganisms for production of glutamic acid |
DE3908201A1 (de) | 1989-03-14 | 1990-09-27 | Degussa | Verfahren zur fermentativen herstellung von l-lysin |
JP3023615B2 (ja) | 1990-08-30 | 2000-03-21 | 協和醗酵工業株式会社 | 発酵法によるl―トリプトファンの製造法 |
DE4130867A1 (de) | 1991-09-17 | 1993-03-18 | Degussa | Verfahren zur fermentativen herstellung von aminosaeuren |
JPH05184366A (ja) | 1992-01-14 | 1993-07-27 | Mitsubishi Petrochem Co Ltd | アスパルトキナーゼをコードする遺伝子dna及びその利用 |
JP3473042B2 (ja) | 1992-04-28 | 2003-12-02 | 味の素株式会社 | 変異型アスパルトキナーゼ遺伝子 |
JPH06261766A (ja) | 1993-03-16 | 1994-09-20 | Mitsubishi Petrochem Co Ltd | フィードバックインヒビションの解除されたアスパルトキナーゼをコードする遺伝子dna及びその利用 |
JPH0970291A (ja) | 1995-06-30 | 1997-03-18 | Ajinomoto Co Inc | 人工トランスポゾンを用いた遺伝子増幅方法 |
DE19547361A1 (de) | 1995-12-19 | 1997-06-26 | Degussa | Verfahren zur Herstellung von L-Aminosäuren durch Fermentation |
JP4035855B2 (ja) | 1996-06-05 | 2008-01-23 | 味の素株式会社 | L−リジンの製造法 |
JP4075087B2 (ja) | 1996-12-05 | 2008-04-16 | 味の素株式会社 | L−リジンの製造法 |
JP4168463B2 (ja) | 1996-12-05 | 2008-10-22 | 味の素株式会社 | L−リジンの製造法 |
US5990350A (en) | 1997-12-16 | 1999-11-23 | Archer Midland Company | Process for making granular L-lysine |
MXPA01010413A (es) | 1999-04-19 | 2002-11-29 | Kyowa Hakko Kogyo Kk | Aspartoquinasa desensibilizada novedosa. |
WO2002097086A1 (fr) * | 2001-05-29 | 2002-12-05 | Kyowa Hakko Kogyo Co., Ltd. | Micro-organismes utiles a echelle industrielle |
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WO2003040373A2 (en) | 2001-08-06 | 2003-05-15 | Degussa Ag | Production of l-lysine by genetically modified corynebacterium glutamicum strains |
WO2005021772A1 (en) | 2003-08-29 | 2005-03-10 | Degussa Ag | Process for the preparation of l-lysine |
CN101578361A (zh) * | 2005-06-17 | 2009-11-11 | 米克罗比亚精密工程股份有限公司 | 改进的氨基酸和代谢物生物合成 |
WO2008101857A2 (en) | 2007-02-19 | 2008-08-28 | Evonik Degussa Gmbh | Coryneform bacteria with formate-thf-synthetase and/or glycine cleavage activity |
WO2009043372A1 (en) * | 2007-10-02 | 2009-04-09 | Metabolic Explorer | Increasing methionine yield |
-
2014
- 2014-04-30 EP EP14166649.5A patent/EP2940039A1/de not_active Withdrawn
-
2015
- 2015-04-16 JP JP2016560989A patent/JP2017518034A/ja active Pending
- 2015-04-16 MY MYPI2016703889A patent/MY181461A/en unknown
- 2015-04-16 WO PCT/EP2015/058280 patent/WO2015165740A2/de active Application Filing
- 2015-04-16 EP EP15717860.9A patent/EP3137492B1/de active Active
- 2015-04-16 RU RU2016143585A patent/RU2713298C2/ru active
- 2015-04-16 KR KR1020167033695A patent/KR102260001B1/ko active IP Right Grant
- 2015-04-16 SG SG11201608281RA patent/SG11201608281RA/en unknown
- 2015-04-16 PL PL15717860T patent/PL3137492T3/pl unknown
- 2015-04-16 BR BR112016025069A patent/BR112016025069A2/pt not_active Application Discontinuation
- 2015-04-16 US US15/307,368 patent/US20170051324A1/en not_active Abandoned
- 2015-04-16 CN CN201580023021.8A patent/CN106536724A/zh active Pending
- 2015-04-16 MX MX2016013953A patent/MX367340B/es active IP Right Grant
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Also Published As
Publication number | Publication date |
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MX2016013953A (es) | 2016-11-09 |
US20170051324A1 (en) | 2017-02-23 |
KR102260001B1 (ko) | 2021-06-02 |
SG11201608281RA (en) | 2016-11-29 |
WO2015165740A3 (de) | 2016-02-25 |
RU2713298C2 (ru) | 2020-02-04 |
PL3137492T3 (pl) | 2019-05-31 |
JP2017518034A (ja) | 2017-07-06 |
EP3137492B1 (de) | 2018-10-17 |
KR20160148006A (ko) | 2016-12-23 |
BR112016025069A2 (pt) | 2017-10-17 |
AR100238A1 (es) | 2016-09-21 |
ES2705405T3 (es) | 2019-03-25 |
EP3137492A2 (de) | 2017-03-08 |
WO2015165740A2 (de) | 2015-11-05 |
RU2016143585A (ru) | 2018-05-08 |
CN106536724A (zh) | 2017-03-22 |
MY181461A (en) | 2020-12-22 |
EP2940039A1 (de) | 2015-11-04 |
RU2016143585A3 (es) | 2019-03-11 |
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