MX362923B - Medios de perfusión. - Google Patents
Medios de perfusión.Info
- Publication number
- MX362923B MX362923B MX2016009980A MX2016009980A MX362923B MX 362923 B MX362923 B MX 362923B MX 2016009980 A MX2016009980 A MX 2016009980A MX 2016009980 A MX2016009980 A MX 2016009980A MX 362923 B MX362923 B MX 362923B
- Authority
- MX
- Mexico
- Prior art keywords
- perfusion media
- perfusion
- media
- titer
- production
- Prior art date
Links
- 230000010412 perfusion Effects 0.000 title abstract 3
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/10—Perfusion
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/525—Tumour necrosis factor [TNF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2523/00—Culture process characterised by temperature
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
- C12N5/16—Animal cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Sustainable Development (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Endocrinology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La presente invención se refiere a un método para fabricar una proteína, caracterizado porque comprende el paso de producir la proteína a través de perfusión en la presencia de un medio de alimentación que comprende una concentración total de aminoácidos de menos de 70 mM, en donde un título de proteína de al menos 300 µg/mL se alcanza en el paso de producción de la proteína, y en donde la proteína es una proteína de fusión TNFR /receptor del factor de necrosis tumoral)-Fc o un anticuerpo anti-TNF.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461933665P | 2014-01-30 | 2014-01-30 | |
PCT/US2015/013524 WO2015116820A1 (en) | 2014-01-30 | 2015-01-29 | Perfusion media |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2016009980A MX2016009980A (es) | 2016-11-15 |
MX362923B true MX362923B (es) | 2019-02-25 |
Family
ID=53678412
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016009980A MX362923B (es) | 2014-01-30 | 2015-01-29 | Medios de perfusión. |
MX2019002182A MX2019002182A (es) | 2014-01-30 | 2016-07-29 | Medios de perfusion. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019002182A MX2019002182A (es) | 2014-01-30 | 2016-07-29 | Medios de perfusion. |
Country Status (13)
Country | Link |
---|---|
US (2) | US10047141B2 (es) |
EP (2) | EP3683316A1 (es) |
JP (2) | JP6749838B2 (es) |
KR (1) | KR20160113710A (es) |
AU (2) | AU2015210930B2 (es) |
BR (1) | BR112016017630A2 (es) |
CA (1) | CA2937965A1 (es) |
EA (2) | EA202092845A1 (es) |
ES (1) | ES2784775T3 (es) |
IL (2) | IL246816B (es) |
MX (2) | MX362923B (es) |
SG (1) | SG11201605860SA (es) |
WO (1) | WO2015116820A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8883146B2 (en) | 2007-11-30 | 2014-11-11 | Abbvie Inc. | Protein formulations and methods of making same |
MX362923B (es) * | 2014-01-30 | 2019-02-25 | Coherus Biosciences Inc | Medios de perfusión. |
JP2022543781A (ja) * | 2019-08-01 | 2022-10-14 | ブリストル-マイヤーズ スクイブ カンパニー | フェッドバッチ細胞培養におけるタンパク質産生性の改良方法 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7294481B1 (en) | 1999-01-05 | 2007-11-13 | Immunex Corporation | Method for producing recombinant proteins |
AU2003303394B2 (en) * | 2002-12-23 | 2009-02-19 | Bristol-Myers Squibb Company | Product quality enhancement in mammalian cell culture processes for protein production |
US7300773B2 (en) | 2004-08-27 | 2007-11-27 | Wyeth Research Ireland Limited | Production of TNFR-Ig |
CN103145838A (zh) | 2005-06-30 | 2013-06-12 | Abbvie公司 | Il-12/p40结合蛋白 |
AT503429B1 (de) | 2006-08-14 | 2007-10-15 | Sticht Fertigungstech Stiwa | Übergabevorrichtung, transportanlage und verfahren zum handhaben von teileträgern |
US20080206819A1 (en) * | 2006-08-21 | 2008-08-28 | Mary Tsao | Intensified Perfusion Production Method |
JP5401319B2 (ja) * | 2006-11-03 | 2014-01-29 | ワイス・エルエルシー | 細胞培養における解糖阻害物質 |
DK2115126T3 (en) | 2007-03-02 | 2015-05-04 | Wyeth Llc | Use of copper and glutamate in cell culture for the preparation of polypeptides |
CN102037132A (zh) * | 2008-04-17 | 2011-04-27 | 惠氏有限责任公司 | 提高骨形成蛋白产量的方法 |
RU2639288C2 (ru) * | 2009-08-11 | 2017-12-20 | Дженентек, Инк. | Получение белков в культуральных средах без глутамина |
US9540426B2 (en) * | 2009-10-06 | 2017-01-10 | Bristol-Myers Squibb Company | Mammalian cell culture processes for protein production |
WO2011134920A1 (en) * | 2010-04-26 | 2011-11-03 | Novartis Ag | Improved cell culture medium |
CA2807607A1 (en) * | 2010-08-20 | 2012-02-23 | Wyeth Llc | Cell culture of growth factor-free adapted cells |
AU2011296702A1 (en) | 2010-08-31 | 2013-03-21 | Friesland Brands B.V. | Culture medium for eukaryotic cells |
CN103827292B (zh) | 2011-07-01 | 2018-01-26 | 安姆根有限公司 | 哺乳动物细胞培养 |
EP2797956A2 (en) * | 2011-12-30 | 2014-11-05 | Abbvie Inc. | Dual variable domain immunoglobulins against receptors |
KR20140130513A (ko) * | 2012-02-29 | 2014-11-10 | 길리아드 바이오로직스, 인크. | 매트릭스 메탈로프로테이나제 9에 대한 항체 |
KR20150014435A (ko) * | 2012-03-08 | 2015-02-06 | 프리슬랜드 브랜즈 비브이 | 진핵 세포용 배양 배지 |
MX362923B (es) * | 2014-01-30 | 2019-02-25 | Coherus Biosciences Inc | Medios de perfusión. |
-
2015
- 2015-01-29 MX MX2016009980A patent/MX362923B/es active IP Right Grant
- 2015-01-29 JP JP2016549376A patent/JP6749838B2/ja not_active Expired - Fee Related
- 2015-01-29 EP EP20162652.0A patent/EP3683316A1/en not_active Withdrawn
- 2015-01-29 ES ES15742902T patent/ES2784775T3/es active Active
- 2015-01-29 US US14/609,225 patent/US10047141B2/en active Active
- 2015-01-29 AU AU2015210930A patent/AU2015210930B2/en not_active Ceased
- 2015-01-29 CA CA2937965A patent/CA2937965A1/en not_active Abandoned
- 2015-01-29 EP EP15742902.8A patent/EP3099324B1/en active Active
- 2015-01-29 BR BR112016017630A patent/BR112016017630A2/pt not_active IP Right Cessation
- 2015-01-29 SG SG11201605860SA patent/SG11201605860SA/en unknown
- 2015-01-29 KR KR1020167023816A patent/KR20160113710A/ko not_active Application Discontinuation
- 2015-01-29 WO PCT/US2015/013524 patent/WO2015116820A1/en active Application Filing
- 2015-01-29 EA EA202092845A patent/EA202092845A1/ru unknown
- 2015-01-29 EA EA201691542A patent/EA037238B1/ru unknown
-
2016
- 2016-07-18 IL IL246816A patent/IL246816B/en active IP Right Grant
- 2016-07-29 MX MX2019002182A patent/MX2019002182A/es unknown
-
2018
- 2018-08-13 US US16/102,157 patent/US11001623B2/en active Active
-
2019
- 2019-06-20 IL IL267558A patent/IL267558B/en unknown
-
2020
- 2020-03-25 JP JP2020053939A patent/JP2020115867A/ja active Pending
- 2020-07-22 AU AU2020207824A patent/AU2020207824A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
MX2016009980A (es) | 2016-11-15 |
US20150210750A1 (en) | 2015-07-30 |
EA201691542A1 (ru) | 2016-12-30 |
IL246816B (en) | 2019-07-31 |
ES2784775T3 (es) | 2020-09-30 |
EP3683316A1 (en) | 2020-07-22 |
MX2019002182A (es) | 2020-11-12 |
EA202092845A1 (ru) | 2021-06-30 |
IL246816A0 (en) | 2016-08-31 |
US10047141B2 (en) | 2018-08-14 |
EP3099324B1 (en) | 2020-04-01 |
EP3099324A4 (en) | 2017-07-12 |
JP2017508448A (ja) | 2017-03-30 |
BR112016017630A2 (pt) | 2017-08-08 |
KR20160113710A (ko) | 2016-09-30 |
IL267558A (en) | 2019-08-29 |
JP2020115867A (ja) | 2020-08-06 |
EA037238B1 (ru) | 2021-02-25 |
IL267558B (en) | 2022-02-01 |
US20180346550A1 (en) | 2018-12-06 |
AU2015210930A1 (en) | 2016-08-04 |
EP3099324A1 (en) | 2016-12-07 |
CA2937965A1 (en) | 2015-08-06 |
US11001623B2 (en) | 2021-05-11 |
AU2015210930B2 (en) | 2020-04-30 |
SG11201605860SA (en) | 2016-08-30 |
JP6749838B2 (ja) | 2020-09-02 |
AU2020207824A1 (en) | 2020-08-06 |
WO2015116820A1 (en) | 2015-08-06 |
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Legal Events
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FG | Grant or registration |