MX360545B - Método para mejorar el perfil de disolución de un material biológicamente activo. - Google Patents
Método para mejorar el perfil de disolución de un material biológicamente activo.Info
- Publication number
- MX360545B MX360545B MX2011011217A MX2011011217A MX360545B MX 360545 B MX360545 B MX 360545B MX 2011011217 A MX2011011217 A MX 2011011217A MX 2011011217 A MX2011011217 A MX 2011011217A MX 360545 B MX360545 B MX 360545B
- Authority
- MX
- Mexico
- Prior art keywords
- active material
- biologically active
- improving
- dissolution profile
- milling
- Prior art date
Links
- 239000011149 active material Substances 0.000 title abstract 4
- 238000004090 dissolution Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000000227 grinding Methods 0.000 abstract 2
- 238000009837 dry grinding Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 238000003801 milling Methods 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/12—Powders or granules
- A01N25/14—Powders or granules wettable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Wood Science & Technology (AREA)
- Environmental Sciences (AREA)
- Organic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Optics & Photonics (AREA)
- Nanotechnology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Disintegrating Or Milling (AREA)
Abstract
La presente invención se refiere a un método para mejorar el perfil de disolución de un material biológicamente activo que comprende las etapas de molienda en seco de un material biológicamente activo sólido y una matriz de molienda que se puede moler en un molino que comprende una pluralidad de cuerpos de molienda, por un periodo de tiempo suficiente para producir partículas del material biológicamente activo dispersado en al menos un material de molido parcialmente molido.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17230109P | 2009-04-24 | 2009-04-24 | |
AU2009901741A AU2009901741A0 (en) | 2009-04-24 | Method for Improving the Dissolution Profile of a Biologically Active Material | |
PCT/AU2010/000465 WO2010121321A1 (en) | 2009-04-24 | 2010-04-23 | Method for improving the dissolution profile of a biologically active material |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2011011217A MX2011011217A (es) | 2012-02-08 |
MX360545B true MX360545B (es) | 2018-10-26 |
Family
ID=43010604
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2011011217A MX360545B (es) | 2009-04-24 | 2010-04-23 | Método para mejorar el perfil de disolución de un material biológicamente activo. |
Country Status (21)
Country | Link |
---|---|
US (5) | US20120165323A1 (es) |
EP (1) | EP2421516A4 (es) |
JP (3) | JP5898613B2 (es) |
KR (3) | KR101873500B1 (es) |
CN (3) | CN102438600A (es) |
AP (2) | AP3629A (es) |
AU (2) | AU2010239160B2 (es) |
BR (1) | BRPI1014277A2 (es) |
CA (1) | CA2759104C (es) |
CO (1) | CO6470804A2 (es) |
EA (1) | EA201171280A1 (es) |
IL (1) | IL215871B (es) |
MA (1) | MA33293B1 (es) |
MX (1) | MX360545B (es) |
MY (1) | MY163538A (es) |
NZ (1) | NZ595972A (es) |
PH (1) | PH12015501781A1 (es) |
SG (1) | SG175308A1 (es) |
UA (1) | UA110772C2 (es) |
WO (1) | WO2010121321A1 (es) |
ZA (1) | ZA201108647B (es) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
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IN2014MN00380A (es) | 2006-06-30 | 2015-06-19 | Iceutica Pty Ltd | |
MX344222B (es) * | 2009-04-24 | 2016-12-07 | Iceutica Pty Ltd | Una formulacion novedosa de naproxeno. |
MY177537A (en) * | 2009-04-24 | 2020-09-17 | Iceutica Pty Ltd | Production of encapsulated nanoparticles at commercial scale |
KR101873500B1 (ko) * | 2009-04-24 | 2018-08-02 | 아이슈티카 피티와이 리미티드 | 생물학적 활성 물질의 용해 프로파일 개선방법 |
CA2759125C (en) | 2009-04-24 | 2017-08-15 | Iceutica Pty Ltd | A novel formulation of indomethacin |
BRPI1014278B8 (pt) * | 2009-04-24 | 2021-05-25 | Iceutica Pty Ltd | método para produzir uma forma de dosagem compreendendo metaxolona, forma de dosagem, composição farmacêutica compreendendo a referida forma de dosagem e uso da mesma |
AP3138A (en) * | 2009-04-24 | 2015-02-28 | Iceutica Pty Ltd | Production of encapsulated nanoparticles at high volume fractions |
WO2014152207A1 (en) * | 2013-03-15 | 2014-09-25 | Mylan Laboratories, Inc. | Hot melt granulation formulations of poorly water-soluble active agents |
US20150157646A1 (en) | 2013-09-27 | 2015-06-11 | Iceutica Inc. | Abiraterone Steroid Formulation |
CN104644556B (zh) * | 2013-11-22 | 2018-05-22 | 沈阳药科大学 | 盐酸依福地平固体粉末及其制备方法 |
AU2015200340B2 (en) * | 2014-02-05 | 2019-01-24 | Upl Limited | Combinations |
US11175268B2 (en) | 2014-06-09 | 2021-11-16 | Biometry Inc. | Mini point of care gas chromatographic test strip and method to measure analytes |
US9526734B2 (en) | 2014-06-09 | 2016-12-27 | Iceutica Pty Ltd. | Formulation of meloxicam |
CA2951690A1 (en) | 2014-06-09 | 2015-12-17 | Biometry Inc. | Low cost test strip and method to measure analyte |
CA2988918A1 (en) * | 2015-06-19 | 2016-12-22 | Biotie Therapies, Inc. | Controlled-release tozadenant formulations |
MX2018004995A (es) * | 2015-10-23 | 2018-07-06 | Basf Se | Soluciones solidas de sustancias odoriferas y agentes aromatizantes con polimeros de vinillactama. |
CN105385739B (zh) * | 2015-12-09 | 2017-09-29 | 梁尚文 | -种从金边蚂蟥中制取蛋白肽的方法 |
AU2017300528C1 (en) | 2016-07-19 | 2022-10-20 | Biometry Inc. | Methods of and systems for measuring analytes using batch calibratable test strips |
CN107853670A (zh) * | 2017-10-30 | 2018-03-30 | 潍坊友容实业有限公司 | 一种盐地碱蓬生物盐提取方法 |
CN108379238B (zh) * | 2018-01-17 | 2020-07-14 | 南昌大学 | 一种储存物理稳定性好的环孢素固体脂质纳米粒及其制备方法 |
US20210106591A1 (en) | 2018-05-11 | 2021-04-15 | Nanjing Delova Biotech Co. Ltd. | Meloxicam composition, preparation and preparation method and use thereof |
AU2019332696A1 (en) * | 2018-08-31 | 2021-03-18 | Kemin Industries, Inc. | Technology for water dispersible phospholipids and lysophospholipids |
JP2022504250A (ja) * | 2018-10-05 | 2022-01-13 | アンパサンド バイオファーマシューティカルズ インコーポレイテッド | ケトンの経皮投与のための製剤および方法 |
US11197830B2 (en) * | 2019-02-27 | 2021-12-14 | Aft Pharmaceuticals Limited | Pharmaceutical composition containing acetaminophen and ibuprofen |
CN113133970A (zh) * | 2020-01-17 | 2021-07-20 | 美国琛蓝营养制品股份有限公司 | 一种姜黄素复合物及其制备方法和检测方法 |
TR202017034A2 (tr) * | 2020-10-26 | 2021-09-21 | Hacettepe Ueniversitesi Rektoerluek | Kuru öğütme yöntemi̇ i̇le hazirlanan ve çözünme hizi arttirilmiş selekoksi̇b i̇çeren farmasöti̇k kompozi̇syonlar |
CN114306253B (zh) * | 2021-11-16 | 2023-08-22 | 扬子江药业集团广州海瑞药业有限公司 | 格列美脲片剂及其制备方法 |
CN113996161B (zh) * | 2021-12-30 | 2022-04-19 | 河北鑫鹏新材料科技有限公司 | 一种硫转移剂及其制备方法和应用 |
CN114732009B (zh) * | 2022-06-13 | 2022-08-23 | 山东百农思达生物科技有限公司 | 一种含有吡唑醚菌酯和烯酰吗啉的水分散粒剂的制备方法 |
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JP2642486B2 (ja) * | 1989-08-04 | 1997-08-20 | 田辺製薬株式会社 | 難溶性薬物の超微粒子化法 |
NZ248813A (en) * | 1992-11-25 | 1995-06-27 | Eastman Kodak Co | Polymeric grinding media used in grinding pharmaceutical substances |
JP4117811B2 (ja) * | 1997-04-22 | 2008-07-16 | 日本化薬株式会社 | フルタミド製剤及びその製法 |
SA99191255B1 (ar) * | 1998-11-30 | 2006-11-25 | جي دي سيرل اند كو | مركبات سيليكوكسيب celecoxib |
JP4969761B2 (ja) * | 2000-08-31 | 2012-07-04 | オバン・エナジー・リミテッド | 所望粒度を持つ固体基材の小粒子および第一材料の小粒状物を含む相乗作用性混合物を製造する方法 |
JP2004099442A (ja) * | 2002-09-04 | 2004-04-02 | Nisshin Pharma Inc | 難溶性薬物含有製剤およびその製造方法 |
CN104083342A (zh) * | 2004-12-31 | 2014-10-08 | 伊休蒂卡有限公司 | 纳米微粒组合物及其合成方法 |
EP1973523A2 (en) * | 2005-12-15 | 2008-10-01 | Acusphere, Inc. | Processes for making particle-based pharmaceutical formulations for pulmonary or nasal administration |
ES2334164T3 (es) * | 2005-12-15 | 2010-03-05 | Acusphere, Inc. | Procedimiento de preparacion de formulaciones farmaceuticas a base de particulas para administracion parenteral. |
IN2014MN00380A (es) | 2006-06-30 | 2015-06-19 | Iceutica Pty Ltd | |
NZ599069A (en) * | 2006-06-30 | 2013-10-25 | Iceutica Pty Ltd | Methods for the Preparation of Biologically Active Compounds in Nanoparticulate Form |
BRPI1014272A2 (pt) * | 2009-04-24 | 2016-10-18 | Iceutica Pty Ltd | nova formulação de diclofenac |
CA2759125C (en) * | 2009-04-24 | 2017-08-15 | Iceutica Pty Ltd | A novel formulation of indomethacin |
KR101873500B1 (ko) * | 2009-04-24 | 2018-08-02 | 아이슈티카 피티와이 리미티드 | 생물학적 활성 물질의 용해 프로파일 개선방법 |
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2010
- 2010-04-23 KR KR1020167021933A patent/KR101873500B1/ko active IP Right Grant
- 2010-04-23 UA UAA201113805A patent/UA110772C2/uk unknown
- 2010-04-23 WO PCT/AU2010/000465 patent/WO2010121321A1/en active Application Filing
- 2010-04-23 AP AP2011005994A patent/AP3629A/xx active
- 2010-04-23 CN CN2010800180042A patent/CN102438600A/zh active Pending
- 2010-04-23 KR KR1020157001083A patent/KR101679522B1/ko active IP Right Grant
- 2010-04-23 AU AU2010239160A patent/AU2010239160B2/en active Active
- 2010-04-23 US US13/265,927 patent/US20120165323A1/en not_active Abandoned
- 2010-04-23 CN CN201510169316.8A patent/CN104825396A/zh active Pending
- 2010-04-23 EA EA201171280A patent/EA201171280A1/ru unknown
- 2010-04-23 SG SG2011077344A patent/SG175308A1/en unknown
- 2010-04-23 KR KR1020117027883A patent/KR20120047207A/ko active Search and Examination
- 2010-04-23 MY MYPI2011005117A patent/MY163538A/en unknown
- 2010-04-23 JP JP2012506283A patent/JP5898613B2/ja active Active
- 2010-04-23 CA CA2759104A patent/CA2759104C/en active Active
- 2010-04-23 CN CN201410083535.XA patent/CN103830243A/zh active Pending
- 2010-04-23 BR BRPI1014277A patent/BRPI1014277A2/pt not_active Application Discontinuation
- 2010-04-23 AP AP2015008965A patent/AP2015008965A0/en unknown
- 2010-04-23 NZ NZ595972A patent/NZ595972A/en unknown
- 2010-04-23 MA MA34379A patent/MA33293B1/fr unknown
- 2010-04-23 MX MX2011011217A patent/MX360545B/es active IP Right Grant
- 2010-04-23 EP EP10766514A patent/EP2421516A4/en not_active Withdrawn
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2011
- 2011-10-23 IL IL215871A patent/IL215871B/en active IP Right Grant
- 2011-11-23 CO CO11160573A patent/CO6470804A2/es not_active Application Discontinuation
- 2011-11-24 ZA ZA2011/08647A patent/ZA201108647B/en unknown
-
2013
- 2013-06-24 US US13/925,325 patent/US20130277468A1/en not_active Abandoned
-
2015
- 2015-04-22 JP JP2015087235A patent/JP2015199736A/ja active Pending
- 2015-08-12 PH PH12015501781A patent/PH12015501781A1/en unknown
- 2015-10-14 AU AU2015243003A patent/AU2015243003A1/en not_active Abandoned
-
2017
- 2017-06-05 JP JP2017110518A patent/JP6619386B2/ja active Active
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2018
- 2018-01-19 US US15/875,794 patent/US20180169018A1/en not_active Abandoned
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2019
- 2019-12-17 US US16/718,105 patent/US20200375903A1/en not_active Abandoned
-
2021
- 2021-09-07 US US17/468,541 patent/US20210401753A1/en active Pending
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