MX356562B - Metodo para producir un producto medicinal que comprende una proteina biologicamente activa y el producto resultante. - Google Patents
Metodo para producir un producto medicinal que comprende una proteina biologicamente activa y el producto resultante.Info
- Publication number
- MX356562B MX356562B MX2015000434A MX2015000434A MX356562B MX 356562 B MX356562 B MX 356562B MX 2015000434 A MX2015000434 A MX 2015000434A MX 2015000434 A MX2015000434 A MX 2015000434A MX 356562 B MX356562 B MX 356562B
- Authority
- MX
- Mexico
- Prior art keywords
- biologically active
- active protein
- product
- frozen
- solvent
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 229940126601 medicinal product Drugs 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000002904 solvent Substances 0.000 abstract 3
- 238000001035 drying Methods 0.000 abstract 2
- 230000000452 restraining effect Effects 0.000 abstract 2
- 230000008014 freezing Effects 0.000 abstract 1
- 238000007710 freezing Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
- A61K39/175—Canine distemper virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/235—Adenoviridae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18411—Morbillivirus, e.g. Measles virus, canine distemper
- C12N2760/18434—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18711—Rubulavirus, e.g. mumps virus, parainfluenza 2,4
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención se refiere a un método para producir un producto medicinal que comprende una proteína biológicamente activa que comprende los pasos de proporcionar una composición acuosa que comprende un solvente, la proteína biológicamente activa y entre 20 % en peso y 60 % en peso de un azúcar no polimérico, congelar la composición, formando así al menos un cuerpo congelado que comprende el solvente en forma congelada, poner el cuerpo congelado en un aparato de secado mientras se transporta por medio de un soporte, el soporte comprende uno o más elementos de restricción que definen uno o más límites del soporte, en donde a lo sumo el 30 % de la superficie del cuerpo es contigua con el uno o más elementos de restricción, reducir la presión en el aparato de secado por debajo de la presión atmosférica, y proporcionar calor al cuerpo para sublimar el solvente congelado del cuerpo y obtener un cuerpo seco; la invención también pertenece a un producto que se puede obtener por medio de este método.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261669797P | 2012-07-10 | 2012-07-10 | |
PCT/EP2013/064422 WO2014009328A1 (en) | 2012-07-10 | 2013-07-09 | A method to produce a medicinal product comprising a biologically active protein and the resulting product |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2015000434A MX2015000434A (es) | 2015-03-12 |
MX356562B true MX356562B (es) | 2018-06-04 |
Family
ID=48747587
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015000434A MX356562B (es) | 2012-07-10 | 2013-07-09 | Metodo para producir un producto medicinal que comprende una proteina biologicamente activa y el producto resultante. |
Country Status (12)
Country | Link |
---|---|
US (4) | US20140017318A1 (es) |
EP (1) | EP2872179B1 (es) |
JP (1) | JP6397405B2 (es) |
CN (1) | CN104428004B (es) |
AU (1) | AU2013289307B2 (es) |
BR (1) | BR112015000404B1 (es) |
CA (1) | CA2878353C (es) |
ES (1) | ES2620084T3 (es) |
MX (1) | MX356562B (es) |
RU (1) | RU2663581C2 (es) |
WO (1) | WO2014009328A1 (es) |
ZA (1) | ZA201409367B (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9314519B2 (en) | 2012-08-21 | 2016-04-19 | Intervet Inc. | Liquid stable virus vaccines |
US9393298B2 (en) | 2013-03-15 | 2016-07-19 | Intervet Inc. | Liquid stable bovine virus vaccines |
US9480739B2 (en) | 2013-03-15 | 2016-11-01 | Intervet Inc. | Bovine virus vaccines that are liquid stable |
AR097762A1 (es) | 2013-09-27 | 2016-04-13 | Intervet Int Bv | Formulaciones secas de vacunas que son estables a temperatura ambiente |
CA2926696A1 (en) | 2013-10-16 | 2015-04-23 | Merck Sharp & Dohme Corp | Thermostable respiratory synctial virus (rsv) vaccine compositions |
CA2927431C (en) | 2013-10-16 | 2023-10-03 | Merck Sharp & Dohme Corp. | Method of microwave vacuum drying spherical-shaped pellets of biological materials |
WO2015057541A1 (en) | 2013-10-16 | 2015-04-23 | Merck Sharp & Dohme Corp. | Method of obtaining thermostable dried vaccine formulations |
AR099470A1 (es) | 2014-02-17 | 2016-07-27 | Intervet Int Bv | Vacunas de virus de aves de corral líquidas |
TWI670085B (zh) | 2014-02-19 | 2019-09-01 | 荷蘭商英特威國際公司 | 液體穩定之豬病毒疫苗 |
FR3024780B1 (fr) * | 2014-08-07 | 2018-11-30 | Bertin Pharma | Reactif pret a l'emploi |
WO2017066134A1 (en) * | 2015-10-16 | 2017-04-20 | Merck Sharp & Dohme Corp. | Processes for preparing formulations for gastrointestinal-targeted therapies |
MX2022007167A (es) * | 2019-12-16 | 2022-10-03 | Univ Northwestern | Reactivos liofilizados. |
CN114159555A (zh) * | 2021-12-08 | 2022-03-11 | 江西赛基生物技术有限公司 | 抗原蛋白冻干小球及其制备方法 |
CN117159480B (zh) * | 2023-11-01 | 2024-03-01 | 江西赛基生物技术有限公司 | 一种重组人IFN-γ蛋白冻干小球及其制备方法和应用 |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3133001A (en) * | 1959-11-26 | 1964-05-12 | Muset Pedro Puig | Stabilization of enzymes |
JPS589688A (ja) * | 1981-07-06 | 1983-01-20 | Toyobo Co Ltd | 安定な酵素組成物 |
US5443959A (en) * | 1992-09-09 | 1995-08-22 | Tokuyama Corporation | Method of assaying fibrinogen, dry reagent therefor, and process for the preparation thereof |
FR2719479B1 (fr) * | 1994-05-04 | 1996-07-26 | Sanofi Elf | Formulation stable lyophilisée comprenant une protéine: kit de dosage. |
US5593824A (en) * | 1994-09-02 | 1997-01-14 | Pharmacia Biotech, Inc. | Biological reagent spheres |
US5565318A (en) | 1994-09-02 | 1996-10-15 | Pharmacia Biotech, Inc. | Room temperature stable reagent semi-spheres |
PT2275119E (pt) * | 1995-07-27 | 2013-11-21 | Genentech Inc | Formulação de proteína liofilizada isotónica estável |
JP2001168002A (ja) * | 1999-12-06 | 2001-06-22 | Mitsubishi Electric Corp | 半導体装置およびその製造に用いるフォトマスクならびにその重ね合わせ精度向上方法 |
AU2001276737A1 (en) * | 2000-08-04 | 2002-02-18 | Chugai Seiyaku Kabushiki Kaisha | Protein injection preparations |
US7923029B2 (en) * | 2002-04-11 | 2011-04-12 | Medimmune Llc | Spray freeze dry of compositions for pulmonary administration |
US6931888B2 (en) * | 2003-02-07 | 2005-08-23 | Ferro Corporation | Lyophilization method and apparatus for producing particles |
US7129778B2 (en) * | 2003-07-23 | 2006-10-31 | Northrop Grumman Corporation | Digital cross cancellation system |
GB2404880B (en) * | 2003-07-25 | 2005-10-12 | Ultrasound Brewery | Ultrasonic solution separator |
CA2552328A1 (en) * | 2004-01-15 | 2005-08-04 | Intervet International B.V. | Non-animal origin stabilizers and processes for producing the same |
RU2283603C1 (ru) * | 2005-02-21 | 2006-09-20 | Калининградский государственный технический университет | Способ сублимационной сушки пищевых продуктов |
US20070259348A1 (en) * | 2005-05-03 | 2007-11-08 | Handylab, Inc. | Lyophilized pellets |
US20070025934A1 (en) * | 2005-07-29 | 2007-02-01 | L'oreal | Nail varnish containing a polyoxyalkylene-chain polymer |
EP2004144A1 (en) * | 2005-12-02 | 2008-12-24 | Stichting Katholieke Universiteit | Method for obtaining hollow particles |
KR101501780B1 (ko) * | 2006-01-24 | 2015-03-16 | 넥스바이오, 인코퍼레이티드 | 고분자 미소 구체들의 조제를 위한 기술 |
EP2117514B1 (en) * | 2007-03-05 | 2011-06-15 | Cadila Healthcare Limited | Compositions comprising peg- interferon alpha conjugates and raffinose as cryoprotectant |
WO2008143782A1 (en) | 2007-05-18 | 2008-11-27 | Medimmune, Llc | Preservation of bioactive materials by freeze dried foam |
TWI436789B (zh) | 2008-01-21 | 2014-05-11 | Intervet Int Bv | 含有藥學化合物的顆粒之冷凍乾燥方法及含有此顆粒的藥學包 |
ES2615390T3 (es) * | 2008-03-05 | 2017-06-06 | Sanofi Pasteur | Proceso para estabilizar una composición de vacuna que contiene adyuvante |
RU2371916C1 (ru) * | 2008-06-04 | 2009-11-10 | Государственное научное учреждение ордена "Знак Почета" Научно-исследовательский институт сельского хозяйства Крайнего Севера Сибирского отделения Российской академии сельскохозяйственных наук (ГНУ НИИСХ КС СО Россельхозакадемии) | Способ консервирования пантов северных оленей с использованием инфракрасного излучения |
CN101983457B (zh) * | 2008-06-19 | 2014-02-05 | 夏普株式会社 | 无线装置 |
US20110113643A1 (en) * | 2008-07-10 | 2011-05-19 | Ulvac, Inc. | Freeze-drying apparatus |
TWI468157B (zh) * | 2009-04-29 | 2015-01-11 | Intervet Int Bv | 形成錠劑的方法,進行該方法的系統及包含該錠劑的包裝物 |
TWI471127B (zh) * | 2009-04-29 | 2015-02-01 | Intervet Int Bv | 供人類使用之口服崩解錠劑的製備方法、所製得之口服崩解錠劑、以及含有該口服崩解錠劑的包裝物 |
TR201906255T4 (tr) * | 2009-12-11 | 2019-05-21 | Pfizer | Terapötik partiküllerin liyofilize edilmesine yönelik stabil formülasyonlar. |
-
2013
- 2013-07-08 US US13/936,500 patent/US20140017318A1/en not_active Abandoned
- 2013-07-09 RU RU2015104159A patent/RU2663581C2/ru active
- 2013-07-09 WO PCT/EP2013/064422 patent/WO2014009328A1/en active Application Filing
- 2013-07-09 ES ES13734433.9T patent/ES2620084T3/es active Active
- 2013-07-09 BR BR112015000404-0A patent/BR112015000404B1/pt active IP Right Grant
- 2013-07-09 US US14/413,341 patent/US20150140102A1/en not_active Abandoned
- 2013-07-09 CA CA2878353A patent/CA2878353C/en active Active
- 2013-07-09 AU AU2013289307A patent/AU2013289307B2/en active Active
- 2013-07-09 EP EP13734433.9A patent/EP2872179B1/en active Active
- 2013-07-09 CN CN201380036052.8A patent/CN104428004B/zh active Active
- 2013-07-09 MX MX2015000434A patent/MX356562B/es active IP Right Grant
- 2013-07-09 JP JP2015520947A patent/JP6397405B2/ja active Active
-
2014
- 2014-12-18 ZA ZA2014/09367A patent/ZA201409367B/en unknown
-
2018
- 2018-05-17 US US15/982,287 patent/US20180369146A1/en not_active Abandoned
-
2020
- 2020-07-01 US US16/918,611 patent/US20200390712A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2015522055A (ja) | 2015-08-03 |
RU2015104159A (ru) | 2016-08-27 |
CA2878353C (en) | 2021-04-20 |
US20140017318A1 (en) | 2014-01-16 |
BR112015000404A2 (pt) | 2017-06-27 |
AU2013289307A1 (en) | 2015-01-22 |
US20150140102A1 (en) | 2015-05-21 |
JP6397405B2 (ja) | 2018-09-26 |
US20180369146A1 (en) | 2018-12-27 |
RU2663581C2 (ru) | 2018-08-07 |
ZA201409367B (en) | 2015-11-25 |
EP2872179B1 (en) | 2017-01-11 |
WO2014009328A1 (en) | 2014-01-16 |
US20200390712A1 (en) | 2020-12-17 |
CN104428004A (zh) | 2015-03-18 |
ES2620084T3 (es) | 2017-06-27 |
MX2015000434A (es) | 2015-03-12 |
CN104428004B (zh) | 2021-03-12 |
AU2013289307B2 (en) | 2017-12-14 |
EP2872179A1 (en) | 2015-05-20 |
BR112015000404B1 (pt) | 2022-08-09 |
CA2878353A1 (en) | 2014-01-16 |
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FG | Grant or registration |