MX355408B - Inhibidores a base de oligonucleotidos que comprenden un motivo de acido nucleico bloqueado. - Google Patents
Inhibidores a base de oligonucleotidos que comprenden un motivo de acido nucleico bloqueado.Info
- Publication number
- MX355408B MX355408B MX2014015643A MX2014015643A MX355408B MX 355408 B MX355408 B MX 355408B MX 2014015643 A MX2014015643 A MX 2014015643A MX 2014015643 A MX2014015643 A MX 2014015643A MX 355408 B MX355408 B MX 355408B
- Authority
- MX
- Mexico
- Prior art keywords
- oligonucleotides
- chemically modified
- oligonucleotide
- locked nucleic
- nucleic acid
- Prior art date
Links
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/113—Antisense targeting other non-coding nucleic acids, e.g. antagomirs
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/317—Chemical structure of the backbone with an inverted bond, e.g. a cap structure
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/323—Chemical structure of the sugar modified ring structure
- C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/343—Spatial arrangement of the modifications having patterns, e.g. ==--==--==--
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/344—Position-specific modifications, e.g. on every purine, at the 3'-end
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/345—Spatial arrangement of the modifications having at least two different backbone modifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
Abstract
La presente invención se refiere a de modificación química para oliqonucleótidos. Los oligonucleótidos de la presente invención, tales como los oligonucleótidos anti-sentido modificados químicamente, pueden tener eficacia aumentada in vivo. Los oligonucleótidos modificados químicamente proporcionan ventajas en uno o más de potencia, eficacia de suministro, especificidad, toxicidad y/o estabilidad blanco. Los oliqonucleótidos modificados químicamente tienen un motivo o patrón de modificación química específica de ácidos nucleicos bloqueados (LNA). El oligonucleótido (por ejemplo el oligonucleótido anti-sentido) puede dirigirse a un ARN, tal como miARN o mARN. También se proporcionan en la presente composiciones que comprenden los oligonucleótidos modificados químicamente y los métodos para utilizar los oligonucleótidos modificados químicamente como terapéuticos para diversos trastornos, entre los que se incluyen trastornos cardiovasculares.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261662746P | 2012-06-21 | 2012-06-21 | |
US201361801533P | 2013-03-15 | 2013-03-15 | |
PCT/US2013/047157 WO2013192576A2 (en) | 2012-06-21 | 2013-06-21 | Oligonucleotide-based inhibitors comprising locked nucleic acid motif |
Publications (2)
Publication Number | Publication Date |
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MX2014015643A MX2014015643A (es) | 2015-07-17 |
MX355408B true MX355408B (es) | 2018-04-18 |
Family
ID=49769732
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014015643A MX355408B (es) | 2012-06-21 | 2013-06-21 | Inhibidores a base de oligonucleotidos que comprenden un motivo de acido nucleico bloqueado. |
Country Status (12)
Country | Link |
---|---|
US (3) | US9388408B2 (es) |
EP (2) | EP3354734B1 (es) |
JP (2) | JP6208228B2 (es) |
KR (1) | KR101928418B1 (es) |
CN (2) | CN107236735B (es) |
AU (1) | AU2013278011B2 (es) |
CA (1) | CA2876180C (es) |
DK (1) | DK3354734T3 (es) |
ES (1) | ES2801875T3 (es) |
HK (2) | HK1209781A1 (es) |
MX (1) | MX355408B (es) |
WO (1) | WO2013192576A2 (es) |
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EP2757157A1 (en) * | 2013-01-17 | 2014-07-23 | Ecole Polytechnique Federale de Lausanne (EPFL) | Modulation of mitophagy and use thereof |
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KR20150023687A (ko) | 2015-03-05 |
WO2013192576A2 (en) | 2013-12-27 |
JP2017217007A (ja) | 2017-12-14 |
CN104685056A (zh) | 2015-06-03 |
US9388408B2 (en) | 2016-07-12 |
CA2876180C (en) | 2019-11-19 |
AU2013278011A1 (en) | 2015-01-15 |
US20180273944A1 (en) | 2018-09-27 |
US9803202B2 (en) | 2017-10-31 |
JP2015521626A (ja) | 2015-07-30 |
HK1244509A1 (zh) | 2018-08-10 |
CA2876180A1 (en) | 2013-12-27 |
US20130344135A1 (en) | 2013-12-26 |
JP6208228B2 (ja) | 2017-10-04 |
WO2013192576A3 (en) | 2014-04-03 |
US10337005B2 (en) | 2019-07-02 |
KR101928418B1 (ko) | 2018-12-12 |
EP2864482A4 (en) | 2016-02-10 |
CN107236735A (zh) | 2017-10-10 |
EP3354734A1 (en) | 2018-08-01 |
CN107236735B (zh) | 2019-11-08 |
HK1209781A1 (en) | 2016-04-08 |
AU2013278011B2 (en) | 2018-09-20 |
MX2014015643A (es) | 2015-07-17 |
US20160326526A1 (en) | 2016-11-10 |
EP3354734B1 (en) | 2020-06-10 |
ES2801875T3 (es) | 2021-01-14 |
DK3354734T3 (da) | 2020-06-29 |
EP2864482A2 (en) | 2015-04-29 |
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