MX343653B - Síntesis de clorhidrato de metilfenidato a baja temperatura. - Google Patents
Síntesis de clorhidrato de metilfenidato a baja temperatura.Info
- Publication number
- MX343653B MX343653B MX2013007020A MX2013007020A MX343653B MX 343653 B MX343653 B MX 343653B MX 2013007020 A MX2013007020 A MX 2013007020A MX 2013007020 A MX2013007020 A MX 2013007020A MX 343653 B MX343653 B MX 343653B
- Authority
- MX
- Mexico
- Prior art keywords
- low
- methylphenidate hydrochloride
- temperature synthesis
- methylphenidate
- hydrochloride
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Abstract
La presente invención describe un proceso para la preparación de clorhidrato de metilfenidato. El proceso implica la esterificación del ácido ritalínico y metanol en presencia de un catalizador ácido a una baja temperatura. El proceso puede involucrar opcionalmente la adición de un ortoéster.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201061424424P | 2010-12-17 | 2010-12-17 | |
PCT/IB2011/003140 WO2012080834A1 (en) | 2010-12-17 | 2011-12-16 | Low-temperature synthesis of methylphenidate hydrochloride |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2013007020A MX2013007020A (es) | 2014-11-10 |
MX343653B true MX343653B (es) | 2016-11-07 |
Family
ID=45509554
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013007020A MX343653B (es) | 2010-12-17 | 2011-12-16 | Síntesis de clorhidrato de metilfenidato a baja temperatura. |
Country Status (13)
Country | Link |
---|---|
US (1) | US9475770B2 (es) |
EP (2) | EP2937336A1 (es) |
JP (1) | JP5886869B2 (es) |
KR (2) | KR101561361B1 (es) |
CN (1) | CN103298785B (es) |
AU (1) | AU2011342894C1 (es) |
BR (1) | BR112013015072A2 (es) |
CA (1) | CA2822016C (es) |
CO (1) | CO6741202A2 (es) |
ES (1) | ES2542433T3 (es) |
MX (1) | MX343653B (es) |
NZ (1) | NZ612298A (es) |
WO (1) | WO2012080834A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014024203A1 (en) * | 2012-08-07 | 2014-02-13 | Zcl Chemicals Limited | An improved process for - the preparation of dexmethylphenidate hydrochloride. |
WO2014083572A1 (en) * | 2012-11-29 | 2014-06-05 | Zcl Chemicals Limited | A process for the preparation of d-threo-ritalinic acid salts via novel salts of intermediate thereof |
EP3066076B1 (en) * | 2013-11-08 | 2019-03-27 | Noramco, Inc. | Process for the preparation of methylphenidate and pharmaceutical salts thereof |
WO2015188092A1 (en) * | 2014-06-06 | 2015-12-10 | Rhodes Pharmaceuticals, L.P. | Methods for treating attention deficit hyperactivity disorder with methylphenidate |
CA2936741C (en) | 2014-10-31 | 2018-11-06 | Purdue Pharma | Methods and compositions particularly for treatment of attention deficit disorder |
CN104744342A (zh) * | 2015-02-11 | 2015-07-01 | 河南中帅医药科技股份有限公司 | 盐酸右哌甲酯晶型及其制备方法 |
CN107325039B (zh) * | 2016-04-29 | 2022-12-16 | 国药集团国瑞药业有限公司 | 一种盐酸右哌甲酯的制备方法 |
US10722473B2 (en) | 2018-11-19 | 2020-07-28 | Purdue Pharma L.P. | Methods and compositions particularly for treatment of attention deficit disorder |
CN110698341A (zh) * | 2019-10-24 | 2020-01-17 | 安庆博曼生物技术有限公司 | 丙炔酸衍生物的环保制备方法 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2507631A (en) | 1944-01-19 | 1950-05-16 | Ciba Pharm Prod Inc | Pyridine and piperidine compounds and process of making same |
US2838519A (en) | 1953-12-23 | 1958-06-10 | Ciba Pharm Prod Inc | Process for the conversion of stereoisomers |
US2957880A (en) | 1953-12-23 | 1960-10-25 | Ciba Pharm Prod Inc | Process for the conversion of stereoisomers |
US4347374A (en) | 1980-07-21 | 1982-08-31 | Merck & Co., Inc. | Acid addition salts of N-trityl-α-fluoromethylhistidine enantiomer derivatives |
US5733756A (en) | 1996-01-05 | 1998-03-31 | Celgene Corporation | Lactams and processes for stereoselective enrichment of lactams, amides, and esters |
US6242464B1 (en) | 1996-01-22 | 2001-06-05 | Chiroscience Limited | Single isomer methylphenidate and resolution process |
GB9604943D0 (en) | 1996-03-08 | 1996-05-08 | Chiroscience Ltd | Resolution |
CA2272373A1 (en) | 1996-12-13 | 1998-06-18 | Medeva Europe Limited | The preparation of enantiomerically-enriched threo-methylphenidate |
GB9700912D0 (en) * | 1997-01-17 | 1997-03-05 | Chiroscience Ltd | Resolution |
US5936091A (en) | 1997-05-22 | 1999-08-10 | Celgene Corporation | Processes and intermediates for resolving piperidyl acetamide stereoisomers |
US6548522B1 (en) | 1999-10-12 | 2003-04-15 | Hoffmann-La Roche Inc. | Method for treating conditions related to the glutamate receptor using carboxylic acid amide derivatives |
US7482366B2 (en) | 2001-12-21 | 2009-01-27 | X-Ceptor Therapeutics, Inc. | Modulators of LXR |
JP2006515014A (ja) | 2003-01-30 | 2006-05-18 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | PKC−θのインヒビターとして有用な2,4−ジアミノピリミジン誘導体 |
CH712083B1 (de) | 2003-02-05 | 2017-07-31 | Siegfried Ag | Verfahren zur Herstellung von d-threo-2-Phenyl-2-piperidin-2-yl-essigsäureestern. |
US20050032873A1 (en) | 2003-07-30 | 2005-02-10 | Wyeth | 3-Amino chroman and 2-amino tetralin derivatives |
US7229557B2 (en) | 2004-02-04 | 2007-06-12 | Konec, Inc. | Method to separate stereoisomers |
KR20090063220A (ko) | 2006-08-24 | 2009-06-17 | 오스트레일리언뉴클리어사이언스앤드테크놀로지오거나이제이션 | 말초 벤조디아제핀 수용체를 표적화하기 위한 플루오르화된리간드 |
US20100022446A1 (en) | 2007-01-18 | 2010-01-28 | Novo Nordisk A/S | Use of Peptides in Combination with Surgical Intervention for the Treatment of Obesity |
WO2010080787A1 (en) | 2009-01-09 | 2010-07-15 | Mallinckrodt Inc. | Synthesis of methylphenidate and analogs thereof |
EP2507212B1 (en) * | 2009-12-01 | 2014-04-16 | Harman Finochem Limited | Process for preparing methyl phenidate hydrochloride |
-
2011
- 2011-12-16 CA CA2822016A patent/CA2822016C/en not_active Expired - Fee Related
- 2011-12-16 KR KR1020137018653A patent/KR101561361B1/ko active IP Right Grant
- 2011-12-16 KR KR20157005468A patent/KR20150029769A/ko not_active Application Discontinuation
- 2011-12-16 EP EP15164269.1A patent/EP2937336A1/en not_active Withdrawn
- 2011-12-16 EP EP20110811127 patent/EP2651892B1/en active Active
- 2011-12-16 JP JP2013543902A patent/JP5886869B2/ja not_active Expired - Fee Related
- 2011-12-16 CN CN201180060441.5A patent/CN103298785B/zh not_active Expired - Fee Related
- 2011-12-16 US US13/994,393 patent/US9475770B2/en active Active
- 2011-12-16 NZ NZ612298A patent/NZ612298A/en not_active IP Right Cessation
- 2011-12-16 WO PCT/IB2011/003140 patent/WO2012080834A1/en active Application Filing
- 2011-12-16 AU AU2011342894A patent/AU2011342894C1/en not_active Ceased
- 2011-12-16 MX MX2013007020A patent/MX343653B/es active IP Right Grant
- 2011-12-16 BR BR112013015072A patent/BR112013015072A2/pt active Search and Examination
- 2011-12-16 ES ES11811127.7T patent/ES2542433T3/es active Active
-
2013
- 2013-07-16 CO CO13168680A patent/CO6741202A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
KR20130115322A (ko) | 2013-10-21 |
MX2013007020A (es) | 2014-11-10 |
EP2937336A1 (en) | 2015-10-28 |
CO6741202A2 (es) | 2013-08-30 |
JP2014503530A (ja) | 2014-02-13 |
AU2011342894A1 (en) | 2013-05-02 |
NZ612298A (en) | 2014-06-27 |
KR20150029769A (ko) | 2015-03-18 |
EP2651892B1 (en) | 2015-04-22 |
BR112013015072A2 (pt) | 2016-07-12 |
US20150038720A1 (en) | 2015-02-05 |
WO2012080834A8 (en) | 2012-09-13 |
WO2012080834A1 (en) | 2012-06-21 |
US9475770B2 (en) | 2016-10-25 |
CA2822016A1 (en) | 2012-06-21 |
JP5886869B2 (ja) | 2016-03-16 |
EP2651892A1 (en) | 2013-10-23 |
CA2822016C (en) | 2016-10-25 |
AU2011342894C1 (en) | 2015-07-30 |
ES2542433T3 (es) | 2015-08-05 |
CN103298785A (zh) | 2013-09-11 |
AU2011342894B2 (en) | 2015-05-07 |
CN103298785B (zh) | 2016-04-20 |
KR101561361B1 (ko) | 2015-10-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |