MX342140B - Sal clorhidrato cristalina de (1-(4-fluorofenil)-1h-indol-5-il)-(3 -(4-(tiazol-2-carbonil)piperazin-1-il) azetidin-1-il)metanona y su uso en el tratamiento del dolor y transtornos metabolicos. - Google Patents

Sal clorhidrato cristalina de (1-(4-fluorofenil)-1h-indol-5-il)-(3 -(4-(tiazol-2-carbonil)piperazin-1-il) azetidin-1-il)metanona y su uso en el tratamiento del dolor y transtornos metabolicos.

Info

Publication number
MX342140B
MX342140B MX2014003898A MX2014003898A MX342140B MX 342140 B MX342140 B MX 342140B MX 2014003898 A MX2014003898 A MX 2014003898A MX 2014003898 A MX2014003898 A MX 2014003898A MX 342140 B MX342140 B MX 342140B
Authority
MX
Mexico
Prior art keywords
pain
methanone
indol
thiazole
fluorophenyl
Prior art date
Application number
MX2014003898A
Other languages
English (en)
Other versions
MX2014003898A (es
Inventor
Kenneth M Wells
Derek A Beauchamp
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MX2014003898A publication Critical patent/MX2014003898A/es
Publication of MX342140B publication Critical patent/MX342140B/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Abstract

La presente invención se refiere a una sal clorhidrato cristalina de (1-(4-fluorofenil)-1H-indol-5-iI)(3-(4-(tiazol-2-carbonil)piper azin-1-iI)azetidin-1-il)metanona, (ver Fórmula) a métodos para hacer dicha sal, composiciones farmacéuticas que contienen dicha sal, y al uso de dicha sal en el tratamiento del dolor y de enfermedades que causan dicho dolor, y trastornos metabólicos, como obesidad, hiperfagia, y diabetes.
MX2014003898A 2011-09-30 2012-09-27 Sal clorhidrato cristalina de (1-(4-fluorofenil)-1h-indol-5-il)-(3 -(4-(tiazol-2-carbonil)piperazin-1-il) azetidin-1-il)metanona y su uso en el tratamiento del dolor y transtornos metabolicos. MX342140B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161541281P 2011-09-30 2011-09-30
PCT/US2012/057461 WO2013049287A1 (en) 2011-09-30 2012-09-27 Crystalline hydrochloride salt of (1- (4 -fluorophenyl) - 1h - indol - 5 - yl) - (3- (4- (thiazole - 2 - carbonyl) piperazin- 1 - yl) az etidin- 1 -yl) methanone and its use in the treatment of pain and metabolic disorders

Publications (2)

Publication Number Publication Date
MX2014003898A MX2014003898A (es) 2014-12-05
MX342140B true MX342140B (es) 2016-09-14

Family

ID=47046853

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014003898A MX342140B (es) 2011-09-30 2012-09-27 Sal clorhidrato cristalina de (1-(4-fluorofenil)-1h-indol-5-il)-(3 -(4-(tiazol-2-carbonil)piperazin-1-il) azetidin-1-il)metanona y su uso en el tratamiento del dolor y transtornos metabolicos.

Country Status (11)

Country Link
US (1) US8835417B2 (es)
EP (1) EP2760861A1 (es)
JP (1) JP2014528427A (es)
KR (1) KR20140072897A (es)
CN (1) CN104271573A (es)
AR (1) AR088198A1 (es)
CA (1) CA2849779A1 (es)
IN (1) IN2014DN02984A (es)
MX (1) MX342140B (es)
TW (1) TW201329073A (es)
WO (1) WO2013049287A1 (es)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1062357A (en) * 1965-03-23 1967-03-22 Pfizer & Co C Quinazolone derivatives
US4337341A (en) * 1976-11-02 1982-06-29 Eli Lilly And Company 4a-Aryl-octahydro-1H-2-pyrindines
US8106208B2 (en) * 2006-05-18 2012-01-31 Albireo Ab Benzamide compounds that act as NK receptor antagonists
FR2915198B1 (fr) * 2007-04-18 2009-12-18 Sanofi Aventis Derives de triazolopyridine-carboxamides et triazolopyridine -carboxamides, leur preparation et leur application en therapeutique.
EP2421848A1 (en) * 2009-04-22 2012-02-29 Janssen Pharmaceutica N.V. Azetidinyl diamides as monoacylglycerol lipase inhibitors

Also Published As

Publication number Publication date
IN2014DN02984A (es) 2015-05-15
CN104271573A (zh) 2015-01-07
CA2849779A1 (en) 2013-04-04
JP2014528427A (ja) 2014-10-27
WO2013049287A1 (en) 2013-04-04
KR20140072897A (ko) 2014-06-13
US8835417B2 (en) 2014-09-16
TW201329073A (zh) 2013-07-16
AR088198A1 (es) 2014-05-14
US20130085279A1 (en) 2013-04-04
MX2014003898A (es) 2014-12-05
EP2760861A1 (en) 2014-08-06

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