MX3412E - PROCEDURE FOR THE PREPARATION OF 3-FLUORINE BENZODIAZEPINES - Google Patents
PROCEDURE FOR THE PREPARATION OF 3-FLUORINE BENZODIAZEPINESInfo
- Publication number
- MX3412E MX3412E MX001783U MX178376U MX3412E MX 3412 E MX3412 E MX 3412E MX 001783 U MX001783 U MX 001783U MX 178376 U MX178376 U MX 178376U MX 3412 E MX3412 E MX 3412E
- Authority
- MX
- Mexico
- Prior art keywords
- hydrogen
- benzodiazepines
- fluorine
- preparation
- procedure
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, ***e
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Anesthesiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente invención se refiere a un procedimiento para la preparación de 3-fluor benzodiazepinas de fórmula: (ver figura). En donde X es cloro, bromo, NO2 o CF3; y es hidrógeno, cloro, bromo o fluor, Z es hidrógeno, hidrocarbilo de 1 a 4 átomos de carbono,-CH2CF3,-CONHR,-CH2CH2NR2 O -CH2CH2NR2A, donde R es aquilo de 1 a 4 átomos de carbono y A es un ácido farmacéuticamente adecuado; B es oxígeno, ó B y Z unidos representanN-NC(R1)-, donde R1 es hidrógeno ó alquilo C1-C4, caracterizado porque consiste en poner en contacto, en condiciones esencialmente anhidras y a una temperatura de -80 A +10ºC aproximadamente, un compuesto de fórmula: (ver figura). donde B, X, Y y Z son los definidos anteriormente y R1 y R2 son individualmente un grupo alquilo primario de 1 a 4 átomos de carbono o unidos representen un grupo -(CH2)4- ó -(CH2)5-.The present invention relates to a process for the preparation of 3-fluor benzodiazepines of the formula: (see figure). Where X is chlorine, bromine, NO2 or CF3; y is hydrogen, chlorine, bromine or fluorine, Z is hydrogen, hydrocarbyl with 1 to 4 carbon atoms, -CH2CF3, -CONHR, -CH2CH2NR2 or -CH2CH2NR2A, where R is 1 to 4 carbon atom alkyl and A is a pharmaceutically suitable acid; B is oxygen, or B and Z together represent N-NC (R1) -, where R1 is hydrogen or C1-C4 alkyl, characterized in that it consists of contacting, under essentially anhydrous conditions and at a temperature of approximately -80 A + 10ºC, a compound of formula: (see figure). where B, X, Y and Z are as defined above and R1 and R2 are individually a primary alkyl group of 1 to 4 carbon atoms or linked represent a group - (CH2) 4- or - (CH2) 5-.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59750275A | 1975-07-21 | 1975-07-21 | |
| US05/687,318 US4246270A (en) | 1976-05-26 | 1976-05-26 | 3-Fluorobenzodiazepines and compositions and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX3412E true MX3412E (en) | 1980-11-06 |
Family
ID=27082840
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX001783U MX3412E (en) | 1975-07-21 | 1976-07-20 | PROCEDURE FOR THE PREPARATION OF 3-FLUORINE BENZODIAZEPINES |
Country Status (22)
| Country | Link |
|---|---|
| JP (1) | JPS5231087A (en) |
| AR (1) | AR211547A1 (en) |
| AU (1) | AU512991B2 (en) |
| CH (1) | CH598234A5 (en) |
| DD (1) | DD126767A5 (en) |
| DE (1) | DE2632539A1 (en) |
| DK (1) | DK326576A (en) |
| ES (1) | ES449960A1 (en) |
| FI (1) | FI762079A (en) |
| FR (1) | FR2318643A1 (en) |
| GB (1) | GB1553599A (en) |
| GR (1) | GR60850B (en) |
| IL (1) | IL50072A0 (en) |
| LU (1) | LU75411A1 (en) |
| MX (1) | MX3412E (en) |
| NL (1) | NL7608074A (en) |
| NO (1) | NO762525L (en) |
| NZ (1) | NZ181516A (en) |
| PH (1) | PH12173A (en) |
| PT (1) | PT65383B (en) |
| SE (1) | SE7606676L (en) |
| SU (1) | SU683618A3 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4182760A (en) * | 1977-06-16 | 1980-01-08 | E. I. Du Pont De Nemours And Company | Benzophenone anti-oximes, diazepin-N-oxides, and their use as pharmaceutical agents and as intermediates for pharmaceutical agents |
| JP2527717Y2 (en) * | 1991-07-19 | 1997-03-05 | 株式会社デンソー | Vehicle instrument mounting structure |
-
1976
- 1976-06-11 SE SE7606676A patent/SE7606676L/en unknown
- 1976-07-19 LU LU75411A patent/LU75411A1/xx unknown
- 1976-07-19 FI FI762079A patent/FI762079A/fi not_active Application Discontinuation
- 1976-07-19 AU AU15988/76A patent/AU512991B2/en not_active Expired
- 1976-07-19 PT PT65383A patent/PT65383B/en unknown
- 1976-07-20 DK DK326576A patent/DK326576A/en unknown
- 1976-07-20 DE DE19762632539 patent/DE2632539A1/en not_active Withdrawn
- 1976-07-20 CH CH929576A patent/CH598234A5/xx not_active IP Right Cessation
- 1976-07-20 AR AR264001A patent/AR211547A1/en active
- 1976-07-20 NO NO762525A patent/NO762525L/no unknown
- 1976-07-20 FR FR7622085A patent/FR2318643A1/en active Granted
- 1976-07-20 IL IL50072A patent/IL50072A0/en unknown
- 1976-07-20 DD DD193980A patent/DD126767A5/xx unknown
- 1976-07-20 MX MX001783U patent/MX3412E/en unknown
- 1976-07-20 PH PH18705A patent/PH12173A/en unknown
- 1976-07-20 SU SU762384509A patent/SU683618A3/en active
- 1976-07-20 GB GB30200/76A patent/GB1553599A/en not_active Expired
- 1976-07-20 NZ NZ181516A patent/NZ181516A/en unknown
- 1976-07-20 ES ES449960A patent/ES449960A1/en not_active Expired
- 1976-07-21 NL NL7608074A patent/NL7608074A/en not_active Application Discontinuation
- 1976-07-21 GR GR51314A patent/GR60850B/en unknown
- 1976-07-21 JP JP51087698A patent/JPS5231087A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| GR60850B (en) | 1978-08-31 |
| AU1598876A (en) | 1978-01-26 |
| GB1553599A (en) | 1979-09-26 |
| LU75411A1 (en) | 1978-02-08 |
| PH12173A (en) | 1978-11-21 |
| CH598234A5 (en) | 1978-04-28 |
| FR2318643B1 (en) | 1980-10-17 |
| JPS5231087A (en) | 1977-03-09 |
| AR211547A1 (en) | 1978-01-30 |
| NL7608074A (en) | 1977-01-25 |
| DD126767A5 (en) | 1977-08-10 |
| SE7606676L (en) | 1977-01-22 |
| NZ181516A (en) | 1978-04-28 |
| DE2632539A1 (en) | 1977-02-10 |
| FI762079A (en) | 1977-01-22 |
| PT65383A (en) | 1976-08-01 |
| SU683618A3 (en) | 1979-08-30 |
| PT65383B (en) | 1978-06-08 |
| NO762525L (en) | 1977-01-24 |
| FR2318643A1 (en) | 1977-02-18 |
| ES449960A1 (en) | 1977-12-01 |
| AU512991B2 (en) | 1980-11-06 |
| DK326576A (en) | 1977-01-22 |
| IL50072A0 (en) | 1976-09-30 |
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