MX3341E - Procedimiento para la preparacion de epoxi-androstanos - Google Patents
Procedimiento para la preparacion de epoxi-androstanosInfo
- Publication number
- MX3341E MX3341E MX001302U MX130276U MX3341E MX 3341 E MX3341 E MX 3341E MX 001302 U MX001302 U MX 001302U MX 130276 U MX130276 U MX 130276U MX 3341 E MX3341 E MX 3341E
- Authority
- MX
- Mexico
- Prior art keywords
- formula
- see
- compound
- epoxy
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
- C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J11/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
Abstract
La presente invención se refiere a un procedimiento para la preparación de epoxi-androstanos, de la fórmual I: (VER FIGURA) en la cual X es halógeno, Z1 y Z2 representan ambas hidrógeno, o bien Z1 es hidroxi y Z2 es cloro, o Z1 y Z2 denotan en conjunto un grupo - epoxi, el cual comprende hacer reaccionar un compuesto de la fórmula V: (VER FIGURA) en la cual R1 y R2 representan ambas hidrógeno o hidroxi, con hidrazina, en un solvente orgánico a una temperatura elevada, preferiblemente al punto de ebullición de la mezcla de reacción, tratar el compuesto obtenido de fórmula IV (ver figura) en donde R1 y R2 tienen los significados anteriores, con una N-halo- succinimida a una temperatura de menos 30 a + 20°C, para proporcionar el compuesto correspondiente de la fórmula III: (ver figura) en donde X, R1 y R2 tienen las definiciones anteriores, y luego hacer reaccionar un compuesto de la fórmula III, donde R1 y R2 son ambas hidrógeno, con un perácido orgánico a una temperatura entre 20 y 30°C, para proporcionar un producto de la fórmula I, en donde Z1 y Z2 son ambas hidrógeno.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU75RI00000572A HU171166B (hu) | 1975-07-15 | 1975-07-15 | Sposob poluchenija novykh ehpoksi-androstanov |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX3341E true MX3341E (es) | 1980-09-30 |
Family
ID=11000981
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX001302U MX3341E (es) | 1975-07-15 | 1976-07-12 | Procedimiento para la preparacion de epoxi-androstanos |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US4110326A (es) |
| JP (1) | JPS5212158A (es) |
| AT (1) | AT351688B (es) |
| AU (1) | AU506285B2 (es) |
| BE (1) | BE844029A (es) |
| CA (1) | CA1071187A (es) |
| CS (2) | CS189796B2 (es) |
| DD (1) | DD126736A5 (es) |
| DE (1) | DE2631717A1 (es) |
| FR (1) | FR2318174A1 (es) |
| GB (1) | GB1533453A (es) |
| HU (1) | HU171166B (es) |
| IL (1) | IL49969A (es) |
| IT (1) | IT1070246B (es) |
| MX (1) | MX3341E (es) |
| NL (1) | NL7607732A (es) |
| PL (1) | PL109164B1 (es) |
| SE (2) | SE418188B (es) |
| SU (2) | SU634675A3 (es) |
| YU (1) | YU174376A (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0008824B1 (en) * | 1978-09-05 | 1982-04-28 | Akzo N.V. | Acid addition salts of 16-beta-monoquaternary ammonium derivatives of 2-beta, 16-beta-bis-piperidino-androstanes and pharmaceutical preparations containing same |
| US5128954A (en) * | 1990-12-14 | 1992-07-07 | Hughes Aircraft Company | Impregnation of a solid from the gas phase |
| DE4227616C2 (de) * | 1992-08-20 | 1995-04-13 | Sigma Tau Ind Farmaceuti | 17-(3-Furyl)-und 17-(4-Pyridazinyl)-5beta, 14beta-androstanderivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammemsetzungen |
| FR2700339B1 (fr) * | 1993-01-14 | 1995-03-03 | Roussel Uclaf | Nouveaux dérivés 17,20-époxydes du pregnane, leur préparation, leur application à la préparation de dérivés cortisoniques et intermédiaires. |
| US5767112A (en) * | 1994-10-21 | 1998-06-16 | Poli Industria Chimica, S.P.A. | Muscle relaxant pharmaceutical compositions |
| IT1277700B1 (it) * | 1995-12-22 | 1997-11-11 | Poli Ind Chimica Spa | Processo di preparazione di 2-beta, 16-beta-diamino 3-alfa, 17-beta- diacilossi 5-alfaandrostani, bloccanti neuromuscolari a struttura |
| DE10010825A1 (de) * | 2000-03-08 | 2001-09-13 | Basf Ag | Verfahren zur Abtrennung eines Azepin-Derivats aus einer Mischung enthaltend ein Amin und ein Azepin-Derivat |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1468539A (fr) * | 1965-02-19 | 1967-02-03 | Organon Labor Ltd | Nouveaux 2beta, 16beta-diamino-androstanes et procédé pour leur préparation |
| GB1138605A (en) * | 1965-02-19 | 1969-01-01 | Organon Labor Ltd | Improvements in or relating to new 2-ß,16-ß-diamino-androstanes |
| HU168431B (es) * | 1972-07-27 | 1976-04-28 | ||
| HU165600B (es) * | 1972-07-27 | 1974-09-28 |
-
1975
- 1975-07-15 HU HU75RI00000572A patent/HU171166B/hu unknown
-
1976
- 1976-07-01 AT AT480476A patent/AT351688B/de not_active IP Right Cessation
- 1976-07-01 SE SE7607550A patent/SE418188B/xx not_active IP Right Cessation
- 1976-07-04 IL IL49969A patent/IL49969A/xx unknown
- 1976-07-06 AU AU15629/76A patent/AU506285B2/en not_active Expired
- 1976-07-09 CS CS773565A patent/CS189796B2/cs unknown
- 1976-07-09 CS CS764572A patent/CS189777B2/cs unknown
- 1976-07-12 DD DD193811A patent/DD126736A5/xx unknown
- 1976-07-12 MX MX001302U patent/MX3341E/es unknown
- 1976-07-12 BE BE168825A patent/BE844029A/xx not_active IP Right Cessation
- 1976-07-12 FR FR7621323A patent/FR2318174A1/fr active Granted
- 1976-07-13 NL NL7607732A patent/NL7607732A/xx not_active Application Discontinuation
- 1976-07-14 PL PL1976191156A patent/PL109164B1/pl unknown
- 1976-07-14 JP JP51083915A patent/JPS5212158A/ja active Granted
- 1976-07-14 IT IT68766/76A patent/IT1070246B/it active
- 1976-07-14 CA CA256,998A patent/CA1071187A/en not_active Expired
- 1976-07-14 DE DE19762631717 patent/DE2631717A1/de active Pending
- 1976-07-14 GB GB29292/76A patent/GB1533453A/en not_active Expired
- 1976-07-14 YU YU01743/76A patent/YU174376A/xx unknown
- 1976-07-15 SU SU762381096A patent/SU634675A3/ru active
-
1977
- 1977-01-25 US US05/762,233 patent/US4110326A/en not_active Expired - Lifetime
- 1977-07-22 SU SU772504513A patent/SU651706A3/ru active
-
1979
- 1979-05-21 SE SE7904404A patent/SE421005B/sv not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PL191156A1 (pl) | 1979-01-29 |
| NL7607732A (nl) | 1977-01-18 |
| AU1562976A (en) | 1978-01-12 |
| JPS5442970B2 (es) | 1979-12-17 |
| FR2318174B1 (es) | 1981-03-20 |
| BE844029A (fr) | 1976-11-03 |
| CS189796B2 (en) | 1979-04-30 |
| CA1071187A (en) | 1980-02-05 |
| IL49969A (en) | 1979-11-30 |
| HU171166B (hu) | 1977-11-28 |
| DD126736A5 (es) | 1977-08-10 |
| SE7607550L (sv) | 1977-01-16 |
| AU506285B2 (en) | 1979-12-20 |
| US4110326A (en) | 1978-08-29 |
| AT351688B (de) | 1979-08-10 |
| PL109164B1 (en) | 1980-05-31 |
| CS189777B2 (en) | 1979-04-30 |
| DE2631717A1 (de) | 1977-01-20 |
| SE7904404L (sv) | 1979-05-21 |
| GB1533453A (en) | 1978-11-22 |
| FR2318174A1 (fr) | 1977-02-11 |
| IT1070246B (it) | 1985-03-29 |
| IL49969A0 (en) | 1976-09-30 |
| ATA480476A (de) | 1979-01-15 |
| SE418188B (sv) | 1981-05-11 |
| YU174376A (en) | 1982-05-31 |
| SU651706A3 (ru) | 1979-03-05 |
| JPS5212158A (en) | 1977-01-29 |
| SE421005B (sv) | 1981-11-16 |
| SU634675A3 (ru) | 1978-11-25 |
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