MX3153E - Procedimiento para la preparacion de 4 - fenil - imidazolinas sustituidas - Google Patents
Procedimiento para la preparacion de 4 - fenil - imidazolinas sustituidasInfo
- Publication number
- MX3153E MX3153E MX000300U MX30076U MX3153E MX 3153 E MX3153 E MX 3153E MX 000300 U MX000300 U MX 000300U MX 30076 U MX30076 U MX 30076U MX 3153 E MX3153 E MX 3153E
- Authority
- MX
- Mexico
- Prior art keywords
- methyl
- see
- chlorine
- formula
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
- C07D233/48—Nitrogen atoms not forming part of a nitro radical with acyclic hydrocarbon or substituted acyclic hydrocarbon radicals, attached to said nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
La presente invención se refiere a un procedimiento para la preparación de 4-fenil-imidazolinas sustituídas de la fórmula general: (VER FIGURA) en la que R1 significa cloro, bromo, flúor o metilo; R2 y R3, que pueden ser iguales o diferentes, significan hidrógeno, cloro o metilo; y R4 significa hidrógeno o un radical metilo o etilo, R5 y R6, que pueden ser iguales o diferentes, significan un radical metilo, etilo o alcoxialcohilo con 2 a 4 átomos de carbono, o forman conjuntamente un anillo de 5, 6 ó 7 miembros eventualmente interumpido por un átomo de nitrógeno o de oxígeno, caracterizado porque se hace reaccionar una imidazolina de la fórmula (VER FIGURA) en donde R1 hasta R3 poseen los significados arriba mencionados y X significa cloro, bromo, yodo o un grupo alcoxi o alcohilmercapto con hasta 4 átomos de carbono, con una amina de la fórmula (VER FIGURA) en donde R4, R5 y R6 poseen los significados antedichos bajo calentamiento, preferiblemente en presencia de un disolvente orgánico, por ejemplo dimetilsulfóxido, dimetilformamida, alcoholes o éteres, y eventualmente se transforma el compuesto obtenido en su sal por adición de ácido.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2525725A DE2525725C3 (de) | 1975-06-10 | 1975-06-10 | Basisch substituierte 2-AIkylamino-4-phenyl-imidazoline, deren Säureadditionssalze, Verfahren zu ihrer Herstellung und deren Verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX3153E true MX3153E (es) | 1980-05-12 |
Family
ID=5948681
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX000300U MX3153E (es) | 1975-06-10 | 1976-06-10 | Procedimiento para la preparacion de 4 - fenil - imidazolinas sustituidas |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US4058616A (es) |
| JP (1) | JPS603066B2 (es) |
| AT (1) | AT351020B (es) |
| AU (1) | AU498253B2 (es) |
| BE (1) | BE842768A (es) |
| CA (1) | CA1069514A (es) |
| CH (1) | CH622785A5 (es) |
| DE (1) | DE2525725C3 (es) |
| DK (1) | DK142172C (es) |
| ES (1) | ES448696A1 (es) |
| FI (1) | FI62069C (es) |
| FR (1) | FR2313926A1 (es) |
| GB (1) | GB1481948A (es) |
| GR (1) | GR60041B (es) |
| IE (1) | IE43793B1 (es) |
| IL (1) | IL49747A (es) |
| LU (1) | LU75114A1 (es) |
| MX (1) | MX3153E (es) |
| NL (1) | NL7606266A (es) |
| NO (1) | NO144214C (es) |
| PT (1) | PT65201B (es) |
| SE (1) | SE422936B (es) |
| ZA (1) | ZA763422B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4105765A (en) * | 1975-06-10 | 1978-08-08 | Boehringer Ingelheim Gmbh | 2-(N-(1,3-diamino-isopropyl)-amino)-4-phenyl-2-imidazolines and salts thereof |
| US4288447A (en) * | 1979-02-06 | 1981-09-08 | A. H. Robins Company, Inc. | Antihyperglycemic 4-substituted 2-iminoimidazolidine compositions |
| US4288591A (en) * | 1979-02-06 | 1981-09-08 | A. H. Robins Company, Inc. | 4-Substituted 2-iminoimidazolidine compounds |
| US4647557A (en) * | 1982-12-28 | 1987-03-03 | Gerard Moinet | Novel heterocyclic derivatives bearing an amino radical, processes for their production and the pharmaceutical compositions containing them |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2586844A (en) * | 1947-10-21 | 1952-02-26 | Ayerst Mckenna & Harrison | Preparation of delta2-1, 3-diazacycloalkenes |
| FR2081571B1 (es) * | 1970-03-12 | 1973-04-06 | Synthelabo |
-
1975
- 1975-06-10 DE DE2525725A patent/DE2525725C3/de not_active Expired
-
1976
- 1976-05-20 AT AT366676A patent/AT351020B/de not_active IP Right Cessation
- 1976-05-20 FI FI761423A patent/FI62069C/fi not_active IP Right Cessation
- 1976-05-27 GR GR50828A patent/GR60041B/el unknown
- 1976-06-03 US US05/692,325 patent/US4058616A/en not_active Expired - Lifetime
- 1976-06-08 LU LU75114A patent/LU75114A1/xx unknown
- 1976-06-08 PT PT65201A patent/PT65201B/pt unknown
- 1976-06-08 CH CH719176A patent/CH622785A5/de not_active IP Right Cessation
- 1976-06-09 BE BE167776A patent/BE842768A/xx not_active IP Right Cessation
- 1976-06-09 IL IL49747A patent/IL49747A/xx unknown
- 1976-06-09 AU AU14770/76A patent/AU498253B2/en not_active Expired
- 1976-06-09 ZA ZA00763422A patent/ZA763422B/xx unknown
- 1976-06-09 ES ES448696A patent/ES448696A1/es not_active Expired
- 1976-06-09 DK DK255976A patent/DK142172C/da not_active IP Right Cessation
- 1976-06-09 GB GB23913/76A patent/GB1481948A/en not_active Expired
- 1976-06-09 NO NO761970A patent/NO144214C/no unknown
- 1976-06-09 SE SE7606497A patent/SE422936B/xx not_active IP Right Cessation
- 1976-06-09 CA CA254,445A patent/CA1069514A/en not_active Expired
- 1976-06-09 JP JP51067548A patent/JPS603066B2/ja not_active Expired
- 1976-06-10 MX MX000300U patent/MX3153E/es unknown
- 1976-06-10 FR FR7617539A patent/FR2313926A1/fr active Granted
- 1976-06-10 IE IE1256/76A patent/IE43793B1/en unknown
- 1976-06-10 NL NL7606266A patent/NL7606266A/xx unknown
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