MX2978E - PROCEDURE FOR THE PREPARATION OF SUBSTITUTED DERIVATIVES OF PIPERAZINE 5 - METHYL OR 5 - METHYL THYR PIRIMIDINE - Google Patents

PROCEDURE FOR THE PREPARATION OF SUBSTITUTED DERIVATIVES OF PIPERAZINE 5 - METHYL OR 5 - METHYL THYR PIRIMIDINE

Info

Publication number
MX2978E
MX2978E MX003804U MX380473U MX2978E MX 2978 E MX2978 E MX 2978E MX 003804 U MX003804 U MX 003804U MX 380473 U MX380473 U MX 380473U MX 2978 E MX2978 E MX 2978E
Authority
MX
Mexico
Prior art keywords
methyl
piperazine
preparation
pyrimidine
see
Prior art date
Application number
MX003804U
Other languages
Spanish (es)
Inventor
Rene Millischer
Francois Percheron
Jean-Merie Claverie
Gerard Loiseau
Georges Mattioda
Original Assignee
Ugine Kuhlmann
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ugine Kuhlmann filed Critical Ugine Kuhlmann
Publication of MX2978E publication Critical patent/MX2978E/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56—One oxygen atom and one sulfur atom

Abstract

La presente invención se refiere a un procedimiento para la preparación de derivados sustituídos de piperazina 5-metil ó 5-metiltio-pirimidina, de la fórmula general: (VER FIGURA), en la que R representa un grupo metilo metiltio, X representa un átomo de halógeno o un grupo alcoxi que tiene de 1 a 5 átomos de carbono, Y representa un grupo acilamino, o amino aventualmente sustituído, Z representa un átomo de hidrógeno, un grupo metilo, etilo, hidroxietilo o fenilo, con la excepción de la metilamina-2-N-metilpiperazina-4 metilotio-5 cloro-5 pirimidina, caracterizado en que se hace reaccionar un dicloro-4,6 pirimidina de fórmula: (VER FIGURA), con una piperazina de fórmula: (VER FIGURA), un medio anhidro, en presencia de un agente que absorbe los ácidos a una temperatura comprendida entre 40 y 120°C.The present invention relates to a process for the preparation of substituted piperazine derivatives 5-methyl or 5-methylthio-pyrimidine, of the general formula: (SEE FIGURE), in which R represents a methyl methylthio group, X represents an atom of halogen or an alkoxy group having 1 to 5 carbon atoms, Y represents an acylamino, or aventually substituted amino group, Z represents a hydrogen atom, a methyl, ethyl, hydroxyethyl or phenyl group, with the exception of methylamine -2-N-methylpiperazine-4-methylothio-5-chloro-5-pyrimidine, characterized in that a dichloro-4,6-pyrimidine of the formula: (SEE FIGURE) is reacted with a piperazine of the formula: (SEE FIGURE), a medium anhydrous, in the presence of an acid-absorbing agent at a temperature between 40 and 120 ° C.

MX003804U 1973-07-06 1973-11-08 PROCEDURE FOR THE PREPARATION OF SUBSTITUTED DERIVATIVES OF PIPERAZINE 5 - METHYL OR 5 - METHYL THYR PIRIMIDINE MX2978E (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7324874A FR2257294B1 (en) 1973-07-06 1973-07-06

Publications (1)

Publication Number Publication Date
MX2978E true MX2978E (en) 1980-01-17

Family

ID=9122191

Family Applications (1)

Application Number Title Priority Date Filing Date
MX003804U MX2978E (en) 1973-07-06 1973-11-08 PROCEDURE FOR THE PREPARATION OF SUBSTITUTED DERIVATIVES OF PIPERAZINE 5 - METHYL OR 5 - METHYL THYR PIRIMIDINE

Country Status (10)

Country Link
JP (1) JPS5849548B2 (en)
BE (1) BE803803A (en)
CH (1) CH582171A5 (en)
DE (1) DE2342880A1 (en)
ES (1) ES418113A1 (en)
FR (1) FR2257294B1 (en)
GB (1) GB1434544A (en)
LU (1) LU68263A1 (en)
MX (1) MX2978E (en)
NO (1) NO137205C (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7605319A (en) * 1975-05-23 1976-11-25 Mar Pha Etu Expl Marques PROCESS FOR PREPARING A MEDICINAL PRODUCT, SUCH MEDICINAL PRODUCT AND PROCESS FOR PREPARING SUITABLE MEDICINAL COMPOUNDS.
FR2417507A2 (en) * 1977-07-28 1979-09-14 Ugine Kuhlmann DIAMINO-2,4 (OR -4,6) METHYLTHIO-5 PYRIMIDINES HERBICIDES
JPS54159877A (en) * 1978-06-07 1979-12-18 Matsushita Electronics Corp Detection method for semiconductor substrate position and break
FR2503162A1 (en) * 1981-04-07 1982-10-08 Pharmindustrie NOVEL PIPERAZINO-2 PYRIMIDINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS OR AS INTERMEDIATES FOR THE PRODUCTION OF MEDICAMENTS
JPS6177335A (en) * 1984-09-25 1986-04-19 Kazumichi Kimura Defective mark detector for semiconductor pellet
IT1191845B (en) * 1986-01-20 1988-03-23 Dompe Farmaceutici Spa PHARMACOLOGICALLY ACTIVE ALCHYLOLS
JPH02114936U (en) * 1989-03-03 1990-09-14

Also Published As

Publication number Publication date
LU68263A1 (en) 1973-10-24
FR2257294B1 (en) 1977-07-01
CH582171A5 (en) 1976-11-30
BE803803A (en) 1974-02-20
ES418113A1 (en) 1976-03-16
DE2342880A1 (en) 1975-01-30
JPS5025578A (en) 1975-03-18
JPS5849548B2 (en) 1983-11-05
NO326073L (en) 1975-02-03
GB1434544A (en) 1976-05-05
FR2257294A1 (en) 1975-08-08
NO137205B (en) 1977-10-10
NO137205C (en) 1978-01-18

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