MX209701B - Proceso para la preparacion de d-treo-(r,r)-metil fenidato y recirculacion de enantiomeros no deseados a traves de epimerizacion. - Google Patents

Proceso para la preparacion de d-treo-(r,r)-metil fenidato y recirculacion de enantiomeros no deseados a traves de epimerizacion.

Info

Publication number: MX209701B
Authority: MX; Mexico
Prior art keywords: threo; epimerisation; recycling; preparation; enantiomers
Prior art date: 1996-02-02

Application number

MX9806209A

Other languages

English (en)

Other versions

MX9806209A (es

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-02-02

Filing date

1998-07-31

Publication date

2002-08-15

1996-02-02 Priority claimed from GBGB9602174.6A external-priority patent/GB9602174D0/en

1996-09-10 Priority claimed from GBGB9618836.2A external-priority patent/GB9618836D0/en

1998-07-31 Application filed filed Critical

1998-10-31 Publication of MX9806209A publication Critical patent/MX9806209A/es

2002-08-15 Publication of MX209701B publication Critical patent/MX209701B/es

Links

HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 2
229960001344 methylphenidate Drugs 0.000 title 1
238000004064 recycling Methods 0.000 title 1
239000000203 mixture Substances 0.000 abstract 3
ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical class O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 abstract 1
DUGOZIWVEXMGBE-OLZOCXBDSA-N methyl (S)-phenyl[(R)-piperidin-2-yl]acetate Chemical compound C([C@@H]1[C@@H](C(=O)OC)C=2C=CC=CC=2)CCCN1 DUGOZIWVEXMGBE-OLZOCXBDSA-N 0.000 abstract 1
238000000926 separation method Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4458—Non condensed piperidines, e.g. piperocaine only substituted in position 2, e.g. methylphenidate
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/0004—Crystallisation cooling by heat exchange
- B01D9/0013—Crystallisation cooling by heat exchange by indirect heat exchange

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Physics & Mathematics (AREA)
Thermal Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Crystallography & Structural Chemistry (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Hydrogenated Pyridines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

MX9806209A 1996-02-02 1998-07-31 Proceso para la preparacion de d-treo-(r,r)-metil fenidato y recirculacion de enantiomeros no deseados a traves de epimerizacion. MX209701B (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9602174.6A GB9602174D0 (en)	1996-02-02	1996-02-02	Resolution/racemization process
GBGB9618836.2A GB9618836D0 (en)	1996-09-10	1996-09-10	Resolution/racemisation process

Publications (2)

Publication Number	Publication Date
MX9806209A MX9806209A (es)	1998-10-31
MX209701B true MX209701B (es)	2002-08-15

Family

ID=26308593

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MX9806209A MX209701B (es)	1996-02-02	1998-07-31	Proceso para la preparacion de d-treo-(r,r)-metil fenidato y recirculacion de enantiomeros no deseados a traves de epimerizacion.

Country Status (16)

Country	Link
US (1)	US7164025B2 (es)
EP (1)	EP0879228B1 (es)
JP (1)	JP2000504008A (es)
KR (1)	KR100453707B1 (es)
AT (1)	ATE226940T1 (es)
AU (1)	AU715183B2 (es)
CA (1)	CA2243534C (es)
CZ (1)	CZ292609B6 (es)
DE (1)	DE69716713T2 (es)
DK (1)	DK0879228T3 (es)
ES (1)	ES2187753T3 (es)
HU (1)	HUP9901658A3 (es)
MX (1)	MX209701B (es)
PT (1)	PT879228E (es)
SK (1)	SK283553B6 (es)
WO (1)	WO1997028124A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5922736A (en) *	1995-12-04	1999-07-13	Celegene Corporation	Chronic, bolus administration of D-threo methylphenidate
US5837284A (en)	1995-12-04	1998-11-17	Mehta; Atul M.	Delivery of multiple doses of medications
US6486177B2 (en)	1995-12-04	2002-11-26	Celgene Corporation	Methods for treatment of cognitive and menopausal disorders with D-threo methylphenidate
GB9700912D0 (en) *	1997-01-17	1997-03-05	Chiroscience Ltd	Resolution
US6962997B1 (en)	1997-05-22	2005-11-08	Celgene Corporation	Process and intermediates for resolving piperidyl acetamide steroisomers
US6100401A (en) *	1998-04-20	2000-08-08	Novartris Ag	Process for preparing the d-threo isomer of methylphenidate hydrochloride
US6025502A (en) *	1999-03-19	2000-02-15	The Trustees Of The University Of Pennsylvania	Enantopselective synthesis of methyl phenidate
US20050239830A1 (en) *	2004-04-26	2005-10-27	Vikram Khetani	Methods of diminishing co-abuse potential
AU2005313887B2 (en) *	2004-12-09	2011-10-27	Celgene Corporation	Treatment using D-threo methylphenidate
US7897777B2 (en) *	2007-01-05	2011-03-01	Archimica, Inc.	Process of enantiomeric resolution of D,L-(±)-threo-methylphenidate
US20130310422A1 (en)	2010-09-01	2013-11-21	The General Hospital Corporation	Reversal of general anesthesia by administration of methylphenidate, amphetamine, modafinil, amantadine, and/or caffeine
US9603809B2 (en)	2011-03-23	2017-03-28	Ironshore Pharmaceuticals & Development, Inc.	Methods of treatment of attention deficit hyperactivity disorder
US9283214B2 (en)	2011-03-23	2016-03-15	Ironshore Pharmaceuticals & Development, Inc.	Compositions for treatment of attention deficit hyperactivity disorder
US9119809B2 (en)	2011-03-23	2015-09-01	Ironshore Pharmaceuticals & Development, Inc.	Compositions for treatment of attention deficit hyperactivity disorder
US9498447B2 (en)	2011-03-23	2016-11-22	Ironshore Pharmaceuticals & Development, Inc.	Compositions for treatment of attention deficit hyperactivity disorder
US8916588B2 (en)	2011-03-23	2014-12-23	Ironshore Pharmaceuticals & Development, Inc.	Methods for treatment of attention deficit hyperactivity disorder
US10292937B2 (en)	2011-03-23	2019-05-21	Ironshore Pharmaceuticals & Development, Inc.	Methods of treatment of attention deficit hyperactivity disorder
US10905652B2 (en)	2011-03-23	2021-02-02	Ironshore Pharmaceuticals & Development, Inc.	Compositions for treatment of attention deficit hyperactivity disorder
US11241391B2 (en)	2011-03-23	2022-02-08	Ironshore Pharmaceuticals & Development, Inc.	Compositions for treatment of attention deficit hyperactivity disorder
CN103608004A (zh)	2011-03-23	2014-02-26	艾伦索尔医药发展股份有限公司	用于治疗注意力缺陷障碍的方法和组合物
US8927010B2 (en)	2011-03-23	2015-01-06	Ironshore Pharmaceuticals & Development, Inc.	Compositions for treatment of attention deficit hyperactivity disorder

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2957880A (en) *	1953-12-23	1960-10-25	Ciba Pharm Prod Inc	Process for the conversion of stereoisomers
SU466229A1 (ru) *	1973-01-23	1975-04-05	Всесоюзный научно-исследовательский химико-фармацевтический институт им. С.Орджоникидзе	Способ получени гидрохлорида метилового эфира трео- -фенил- (пиперидил-2)-уксусной кислоты
US4254261A (en) *	1979-10-15	1981-03-03	Merck & Co., Inc.	Dehydroabietylammonium salts of 6-oxo-2-piperidinecarboxylic acid
US5733756A (en) *	1996-01-05	1998-03-31	Celgene Corporation	Lactams and processes for stereoselective enrichment of lactams, amides, and esters
US6242464B1 (en) *	1996-01-22	2001-06-05	Chiroscience Limited	Single isomer methylphenidate and resolution process
MX9805870A (es) *	1996-01-22	1999-01-31
GB9604943D0 (en) *	1996-03-08	1996-05-08	Chiroscience Ltd	Resolution

1997
- 1997-01-31 DE DE69716713T patent/DE69716713T2/de not_active Expired - Fee Related
- 1997-01-31 AT AT97902435T patent/ATE226940T1/de not_active IP Right Cessation
- 1997-01-31 AU AU16082/97A patent/AU715183B2/en not_active Ceased
- 1997-01-31 CZ CZ19982275A patent/CZ292609B6/cs not_active IP Right Cessation
- 1997-01-31 ES ES97902435T patent/ES2187753T3/es not_active Expired - Lifetime
- 1997-01-31 KR KR19980705911A patent/KR100453707B1/ko not_active IP Right Cessation
- 1997-01-31 PT PT97902435T patent/PT879228E/pt unknown
- 1997-01-31 HU HU9901658A patent/HUP9901658A3/hu unknown
- 1997-01-31 EP EP97902435A patent/EP0879228B1/en not_active Expired - Lifetime
- 1997-01-31 WO PCT/GB1997/000281 patent/WO1997028124A1/en active IP Right Grant
- 1997-01-31 JP JP9527425A patent/JP2000504008A/ja not_active Ceased
- 1997-01-31 DK DK97902435T patent/DK0879228T3/da active
- 1997-01-31 SK SK979-98A patent/SK283553B6/sk unknown
- 1997-01-31 CA CA002243534A patent/CA2243534C/en not_active Expired - Fee Related
1998
- 1998-07-31 MX MX9806209A patent/MX209701B/es not_active IP Right Cessation
2001
- 2001-08-10 US US09/928,139 patent/US7164025B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
PT879228E (pt)	2003-01-31
DE69716713T2 (de)	2003-07-03
AU715183B2 (en)	2000-01-20
KR19990082186A (ko)	1999-11-25
HUP9901658A2 (hu)	1999-09-28
SK283553B6 (sk)	2003-09-11
SK97998A3 (en)	1999-01-11
CA2243534A1 (en)	1997-08-07
HUP9901658A3 (en)	1999-12-28
DK0879228T3 (da)	2003-03-03
ES2187753T3 (es)	2003-06-16
CA2243534C (en)	2003-08-26
EP0879228B1 (en)	2002-10-30
CZ227598A3 (cs)	1998-12-16
MX9806209A (es)	1998-10-31
US7164025B2 (en)	2007-01-16
WO1997028124A1 (en)	1997-08-07
DE69716713D1 (de)	2002-12-05
AU1608297A (en)	1997-08-22
CZ292609B6 (cs)	2003-11-12
JP2000504008A (ja)	2000-04-04
US20020032335A1 (en)	2002-03-14
KR100453707B1 (ko)	2005-01-25
ATE226940T1 (de)	2002-11-15
EP0879228A1 (en)	1998-11-25

Legal Events

Date	Code	Title	Description
2002-08-15	FG	Grant or registration
2017-02-28	MM	Annulment or lapse due to non-payment of fees

Publication	Publication Date	Title
MX209701B (es)	2002-08-15	Proceso para la preparacion de d-treo-(r,r)-metil fenidato y recirculacion de enantiomeros no deseados a traves de epimerizacion.
IE891859L (en)	1989-12-14	New enantiomers and their isolation
MY121543A (en)	2006-02-28	Preparation of 3,4,4-trisubstituted-piperidinyl-n- alkylcarboxylates and intermediates
ATE188476T1 (de)	2000-01-15	Polyzyklische antiparasitäre derivate, verfahren und stamm zu ihrer herstellung und ihrer verwendung
IL122012A0 (en)	1998-03-10	Process for the separation of a mixture of enantiomers
HU9601857D0 (en)	1996-08-28	New benzyl-piperidine- or -tetrahydro-pyridine derivatives and processes for producing them
NZ294191A (en)	1998-10-28	Process for preparing 4a,5,9,10,11,12-hexahydro-6h-benzofuro[3a,3,2-ef][2]benzazepine derivatives and intermediates thereof
MY116593A (en)	2004-02-28	Process for the preparation of o-demethyltramadol enantiomers
AU2102497A (en)	1997-09-22	Resolution of threo-methylphenidate
BG102788A (en)	1999-05-31	New methods for the preparation of intermediate compounds for presticides
BG101969A (en)	1998-05-29	Process for preparing racemic and enantiomeric 1-(pyridyl)-2-cyclohexylethylamine
AU6578400A (en)	2001-02-13	Novel method for preparing benzoperhydroisoindole compounds
MY132710A (en)	2007-10-31	Method for separating an imine from a mixture containing an amine and an imine
UA48993C2 (uk)	2002-09-16	СПОСІБ ОТРИМАННЯ N-АЦЕТИЛ-(L)-4-ЦІАНОФЕНІЛАЛАНІНУ Аc-(L)-Phe(4-CN)-OH І N-АЦЕТИЛ-(L)-П-АМІДИНФЕНІЛАЛАНІН-ЦИКЛОГЕКСИЛГЛІЦИН-<font face="Symbol">b</font>-(3-N-МЕТИЛПІРИДИН)-АЛАНІНУ Аc-(L)-pАph-Сhg-PalMe(3)-NH<sub>2</sub>
MY120471A (en)	2005-10-31	Method for producing enantiomer-free n-methyl-n-[(1s)-1-phenyl-2-((3s)-3-hydroxypyrolidine-1-yl) ethyl]-2, 2-diphenylacetamide.
EP0934250A4 (en)	2004-08-11	PROCESS FOR THE PREPARATION OF PHARMACEUTICAL COMPOUNDS
MY115259A (en)	2003-04-30	Process for the preparation of nmda antagonists
HU9600187D0 (en)	1996-03-28	General process for separation of enantiomers of alfa-hidroxi carbonacid-esters