MX2023005491A - Métodos de preparación de células t rejuvenecidas, composiciones que las comprenden y métodos de uso de las mismas. - Google Patents

Métodos de preparación de células t rejuvenecidas, composiciones que las comprenden y métodos de uso de las mismas.

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Publication number
MX2023005491A
MX2023005491A MX2023005491A MX2023005491A MX2023005491A MX 2023005491 A MX2023005491 A MX 2023005491A MX 2023005491 A MX2023005491 A MX 2023005491A MX 2023005491 A MX2023005491 A MX 2023005491A MX 2023005491 A MX2023005491 A MX 2023005491A
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MX
Mexico
Prior art keywords
methods
cells
compositions
rejuvenated
making
Prior art date
Application number
MX2023005491A
Other languages
English (en)
Inventor
Yasuhiro Yamazaki
Sakoda Raul E Vizcardo
Nicholas Restifo
Richard D Klausner
Yin Huang
Takuya Maeda
Naritaka Tamaoki
Original Assignee
Lyell Immunopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lyell Immunopharma Inc filed Critical Lyell Immunopharma Inc
Publication of MX2023005491A publication Critical patent/MX2023005491A/es

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    • C—CHEMISTRY; METALLURGY
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/463—Cellular immunotherapy characterised by recombinant expression
    • A61K39/4631—Chimeric Antigen Receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/463—Cellular immunotherapy characterised by recombinant expression
    • A61K39/4632—T-cell receptors [TCR]; antibody T-cell receptor constructs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464402—Receptors, cell surface antigens or cell surface determinants
    • A61K39/464411—Immunoglobulin superfamily
    • A61K39/464412—CD19 or B4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464484—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
    • A61K39/464488—NY-ESO
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C12N2501/20—Cytokines; Chemokines
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    • C12N2501/50—Cell markers; Cell surface determinants
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2760/18843—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Peptides Or Proteins (AREA)

Abstract

La presente descripción se refiere en general a métodos de producción de células T rejuvenecidas, que comprenden poner en contacto células T con al menos un factor de reprogramación y reactivar las células contactadas y composiciones y métodos de uso de las mismas. La presente descripción también describe poblaciones de células preparadas de acuerdo con los métodos descritos en la presente. La descripción también proporciona métodos de tratamiento de pacientes usando poblaciones de células preparadas mediante los métodos descritos en la presente.
MX2023005491A 2020-11-24 2021-11-23 Métodos de preparación de células t rejuvenecidas, composiciones que las comprenden y métodos de uso de las mismas. MX2023005491A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202063117787P 2020-11-24 2020-11-24
US202163153881P 2021-02-25 2021-02-25
US202163165093P 2021-03-23 2021-03-23
PCT/US2021/060650 WO2022115492A1 (en) 2020-11-24 2021-11-23 Methods for making, compositions comprising, and methods of using rejuvenated t cells

Publications (1)

Publication Number Publication Date
MX2023005491A true MX2023005491A (es) 2023-08-09

Family

ID=81657994

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2023005491A MX2023005491A (es) 2020-11-24 2021-11-23 Métodos de preparación de células t rejuvenecidas, composiciones que las comprenden y métodos de uso de las mismas.

Country Status (10)

Country Link
US (1) US20220162551A1 (es)
EP (1) EP4251742A1 (es)
JP (1) JP2023553815A (es)
KR (1) KR20230113767A (es)
AU (1) AU2021386370A1 (es)
CA (1) CA3172507A1 (es)
IL (1) IL302744A (es)
MX (1) MX2023005491A (es)
TW (1) TW202235094A (es)
WO (1) WO2022115492A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023201097A1 (en) * 2022-04-15 2023-10-19 Turn Biotechnologies, Inc. Methods and compositions for immune cell rejuvenation and therapies using rejuvenated immune cells

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9206394B2 (en) * 2010-02-03 2015-12-08 The University Of Tokyo Method for reconstructing immune function using pluripotent stem cells
JP6584776B2 (ja) * 2011-04-08 2019-10-02 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 細胞を幼若化するための方法
US20140162366A1 (en) * 2012-08-31 2014-06-12 Salk Institute For Biological Studies Generation of vascular progenitor cells
WO2015039100A1 (en) * 2013-09-16 2015-03-19 The Trustees Of The University Of Pennsylvania Cd137 enrichment for efficient tumor infiltrating lymphocyte selection
JP6928604B2 (ja) * 2015-11-04 2021-09-01 フェイト セラピューティクス，インコーポレイテッド 万能性細胞のゲノム改変
WO2018209324A2 (en) * 2017-05-11 2018-11-15 The Broad Institute, Inc. Methods and compositions of use of cd8+ tumor infiltrating lymphocyte subtypes and gene signatures thereof
EP3752602A4 (en) * 2018-02-14 2021-11-24 Sunnybrook Research Institute METHOD OF GENERATING CELLS OF THE T CELL LINE
MX2020009491A (es) * 2018-03-13 2020-10-28 Univ Leland Stanford Junior Reprogramacion celular transitoria para revertir el envejecimiento celular.

Also Published As

Publication number Publication date
TW202235094A (zh) 2022-09-16
IL302744A (en) 2023-07-01
EP4251742A1 (en) 2023-10-04
US20220162551A1 (en) 2022-05-26
JP2023553815A (ja) 2023-12-26
AU2021386370A1 (en) 2023-06-22
KR20230113767A (ko) 2023-08-01
WO2022115492A9 (en) 2022-08-25
CA3172507A1 (en) 2022-06-02
WO2022115492A1 (en) 2022-06-02

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