MX2023003687A - Modelado predictivo hibrido y el control de cultivo celular. - Google Patents
Modelado predictivo hibrido y el control de cultivo celular.Info
- Publication number
- MX2023003687A MX2023003687A MX2023003687A MX2023003687A MX2023003687A MX 2023003687 A MX2023003687 A MX 2023003687A MX 2023003687 A MX2023003687 A MX 2023003687A MX 2023003687 A MX2023003687 A MX 2023003687A MX 2023003687 A MX2023003687 A MX 2023003687A
- Authority
- MX
- Mexico
- Prior art keywords
- cell culture
- controlling
- inputs
- control
- predictive modeling
- Prior art date
Links
- 238000004113 cell culture Methods 0.000 title abstract 10
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/48—Automatic or computerized control
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
- C12M41/32—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of substances in solution
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
- G06N3/00—Computing arrangements based on biological models
- G06N3/02—Neural networks
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Sustainable Development (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Computer Hardware Design (AREA)
- Physics & Mathematics (AREA)
- Theoretical Computer Science (AREA)
- Computational Linguistics (AREA)
- Biophysics (AREA)
- Data Mining & Analysis (AREA)
- Evolutionary Computation (AREA)
- Molecular Biology (AREA)
- Computing Systems (AREA)
- General Physics & Mathematics (AREA)
- Mathematical Physics (AREA)
- Software Systems (AREA)
- Artificial Intelligence (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Un método de control de un procedimiento de cultivo celular incluye, para cada intervalo de tiempo de uno o más intervalos de tiempo durante el procedimiento de cultivo celular, obtener valores actuales de uno o más atributos de cultivo celular asociados con un cultivo celular, predecir uno o más valores futuros de un atributo de cultivo celular particular asociado con el cultivo celular, y controlar una o más entradas físicas para el procedimiento de cultivo celular. Predecir el/los valor(es) futuro(s) incluye aplicar los valores actuales del/de los atributo(s) de cultivo celular y un valor anterior de al menos uno de los atributos de cultivo celular, como entradas para un modelo predictivo basado en datos usando datos históricos. Controlar la(s) entrada(s) física(s) incluye aplicar el/los valor(es) futuro(s) como entradas para un controlador predictivo de modelo.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063086417P | 2020-10-01 | 2020-10-01 | |
| PCT/US2021/051570 WO2022072198A1 (en) | 2020-10-01 | 2021-09-22 | Predictive modeling and control of cell culture |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2023003687A true MX2023003687A (es) | 2023-04-20 |
Family
ID=78599116
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2023003687A MX2023003687A (es) | 2020-10-01 | 2021-09-22 | Modelado predictivo hibrido y el control de cultivo celular. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20230272331A1 (es) |
| EP (1) | EP4204538A1 (es) |
| JP (1) | JP2023544029A (es) |
| KR (1) | KR20230076842A (es) |
| CN (1) | CN116457453A (es) |
| AU (1) | AU2021355381A1 (es) |
| CA (1) | CA3196821A1 (es) |
| CL (1) | CL2023000946A1 (es) |
| IL (1) | IL301648A (es) |
| MX (1) | MX2023003687A (es) |
| WO (1) | WO2022072198A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024055008A1 (en) * | 2022-09-09 | 2024-03-14 | Genentech, Inc. | Prediction of viability of cell culture during a biomolecule manufacturing process |
| CN116926241B (zh) * | 2023-06-30 | 2024-07-19 | 广东美赛尔细胞生物科技有限公司 | 一种免疫细胞培养控制方法及*** |
| CN117235673B (zh) * | 2023-11-15 | 2024-01-30 | 中南大学 | 一种细胞培养预测方法及装置、电子设备、存储介质 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3164481A4 (en) * | 2014-07-02 | 2018-03-21 | Biogen MA Inc. | Cross-scale modeling of bioreactor cultures using raman spectroscopy |
| CN111630148A (zh) * | 2017-11-20 | 2020-09-04 | 隆萨有限公司 | 在防止乳酸积累的同时繁殖细胞培养物的过程和*** |
| JP7092879B2 (ja) * | 2017-12-29 | 2022-06-28 | エフ．ホフマン－ラ ロシュ アーゲー | 細胞培養物の代謝状態の予測 |
| WO2020041454A1 (en) * | 2018-08-21 | 2020-02-27 | Lonza Ltd | A process for creating reference data for predicting concentrations of quality attributes |
| KR20210078531A (ko) * | 2018-10-23 | 2021-06-28 | 암젠 인크 | 실시간 예측을 위한 라만 분광 모델의 자동 교정 및 자동 유지 관리 |
-
2021
- 2021-09-22 CN CN202180077069.2A patent/CN116457453A/zh active Pending
- 2021-09-22 EP EP21806433.5A patent/EP4204538A1/en active Pending
- 2021-09-22 AU AU2021355381A patent/AU2021355381A1/en active Pending
- 2021-09-22 KR KR1020237014248A patent/KR20230076842A/ko unknown
- 2021-09-22 CA CA3196821A patent/CA3196821A1/en active Pending
- 2021-09-22 US US18/029,715 patent/US20230272331A1/en active Pending
- 2021-09-22 JP JP2023519646A patent/JP2023544029A/ja active Pending
- 2021-09-22 IL IL301648A patent/IL301648A/en unknown
- 2021-09-22 MX MX2023003687A patent/MX2023003687A/es unknown
- 2021-09-22 WO PCT/US2021/051570 patent/WO2022072198A1/en active Application Filing
-
2023
- 2023-03-30 CL CL2023000946A patent/CL2023000946A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL301648A (en) | 2023-05-01 |
| JP2023544029A (ja) | 2023-10-19 |
| CA3196821A1 (en) | 2022-04-07 |
| WO2022072198A1 (en) | 2022-04-07 |
| CN116457453A (zh) | 2023-07-18 |
| EP4204538A1 (en) | 2023-07-05 |
| KR20230076842A (ko) | 2023-05-31 |
| AU2021355381A1 (en) | 2023-05-04 |
| CL2023000946A1 (es) | 2023-09-08 |
| US20230272331A1 (en) | 2023-08-31 |
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