MX2023003687A - Modelado predictivo hibrido y el control de cultivo celular. - Google Patents
Modelado predictivo hibrido y el control de cultivo celular.Info
- Publication number
- MX2023003687A MX2023003687A MX2023003687A MX2023003687A MX2023003687A MX 2023003687 A MX2023003687 A MX 2023003687A MX 2023003687 A MX2023003687 A MX 2023003687A MX 2023003687 A MX2023003687 A MX 2023003687A MX 2023003687 A MX2023003687 A MX 2023003687A
- Authority
- MX
- Mexico
- Prior art keywords
- cell culture
- controlling
- inputs
- control
- predictive modeling
- Prior art date
Links
- 238000004113 cell culture Methods 0.000 title abstract 10
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/48—Automatic or computerized control
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
- C12M41/32—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of substances in solution
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
- G06N3/00—Computing arrangements based on biological models
- G06N3/02—Neural networks
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Sustainable Development (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Computer Hardware Design (AREA)
- Physics & Mathematics (AREA)
- Theoretical Computer Science (AREA)
- Computational Linguistics (AREA)
- Biophysics (AREA)
- Data Mining & Analysis (AREA)
- Evolutionary Computation (AREA)
- Molecular Biology (AREA)
- Computing Systems (AREA)
- General Physics & Mathematics (AREA)
- Mathematical Physics (AREA)
- Software Systems (AREA)
- Artificial Intelligence (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Un método de control de un procedimiento de cultivo celular incluye, para cada intervalo de tiempo de uno o más intervalos de tiempo durante el procedimiento de cultivo celular, obtener valores actuales de uno o más atributos de cultivo celular asociados con un cultivo celular, predecir uno o más valores futuros de un atributo de cultivo celular particular asociado con el cultivo celular, y controlar una o más entradas físicas para el procedimiento de cultivo celular. Predecir el/los valor(es) futuro(s) incluye aplicar los valores actuales del/de los atributo(s) de cultivo celular y un valor anterior de al menos uno de los atributos de cultivo celular, como entradas para un modelo predictivo basado en datos usando datos históricos. Controlar la(s) entrada(s) física(s) incluye aplicar el/los valor(es) futuro(s) como entradas para un controlador predictivo de modelo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063086417P | 2020-10-01 | 2020-10-01 | |
PCT/US2021/051570 WO2022072198A1 (en) | 2020-10-01 | 2021-09-22 | Predictive modeling and control of cell culture |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2023003687A true MX2023003687A (es) | 2023-04-20 |
Family
ID=78599116
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2023003687A MX2023003687A (es) | 2020-10-01 | 2021-09-22 | Modelado predictivo hibrido y el control de cultivo celular. |
Country Status (11)
Country | Link |
---|---|
US (1) | US20230272331A1 (es) |
EP (1) | EP4204538A1 (es) |
JP (1) | JP2023544029A (es) |
KR (1) | KR20230076842A (es) |
CN (1) | CN116457453A (es) |
AU (1) | AU2021355381A1 (es) |
CA (1) | CA3196821A1 (es) |
CL (1) | CL2023000946A1 (es) |
IL (1) | IL301648A (es) |
MX (1) | MX2023003687A (es) |
WO (1) | WO2022072198A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2024055008A1 (en) * | 2022-09-09 | 2024-03-14 | Genentech, Inc. | Prediction of viability of cell culture during a biomolecule manufacturing process |
CN116926241B (zh) * | 2023-06-30 | 2024-07-19 | 广东美赛尔细胞生物科技有限公司 | 一种免疫细胞培养控制方法及*** |
CN117235673B (zh) * | 2023-11-15 | 2024-01-30 | 中南大学 | 一种细胞培养预测方法及装置、电子设备、存储介质 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3164481A4 (en) * | 2014-07-02 | 2018-03-21 | Biogen MA Inc. | Cross-scale modeling of bioreactor cultures using raman spectroscopy |
CN111630148A (zh) * | 2017-11-20 | 2020-09-04 | 隆萨有限公司 | 在防止乳酸积累的同时繁殖细胞培养物的过程和*** |
JP7092879B2 (ja) * | 2017-12-29 | 2022-06-28 | エフ.ホフマン-ラ ロシュ アーゲー | 細胞培養物の代謝状態の予測 |
WO2020041454A1 (en) * | 2018-08-21 | 2020-02-27 | Lonza Ltd | A process for creating reference data for predicting concentrations of quality attributes |
KR20210078531A (ko) * | 2018-10-23 | 2021-06-28 | 암젠 인크 | 실시간 예측을 위한 라만 분광 모델의 자동 교정 및 자동 유지 관리 |
-
2021
- 2021-09-22 CN CN202180077069.2A patent/CN116457453A/zh active Pending
- 2021-09-22 EP EP21806433.5A patent/EP4204538A1/en active Pending
- 2021-09-22 AU AU2021355381A patent/AU2021355381A1/en active Pending
- 2021-09-22 KR KR1020237014248A patent/KR20230076842A/ko unknown
- 2021-09-22 CA CA3196821A patent/CA3196821A1/en active Pending
- 2021-09-22 US US18/029,715 patent/US20230272331A1/en active Pending
- 2021-09-22 JP JP2023519646A patent/JP2023544029A/ja active Pending
- 2021-09-22 IL IL301648A patent/IL301648A/en unknown
- 2021-09-22 MX MX2023003687A patent/MX2023003687A/es unknown
- 2021-09-22 WO PCT/US2021/051570 patent/WO2022072198A1/en active Application Filing
-
2023
- 2023-03-30 CL CL2023000946A patent/CL2023000946A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
IL301648A (en) | 2023-05-01 |
JP2023544029A (ja) | 2023-10-19 |
CA3196821A1 (en) | 2022-04-07 |
WO2022072198A1 (en) | 2022-04-07 |
CN116457453A (zh) | 2023-07-18 |
EP4204538A1 (en) | 2023-07-05 |
KR20230076842A (ko) | 2023-05-31 |
AU2021355381A1 (en) | 2023-05-04 |
CL2023000946A1 (es) | 2023-09-08 |
US20230272331A1 (en) | 2023-08-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2023003687A (es) | Modelado predictivo hibrido y el control de cultivo celular. | |
WO2019212653A8 (en) | Computer system and method for automated batch data alignment in batch process modeling, monitoring and control | |
GB2590237A (en) | Hybrid physics-based and machine learning models for reservoir simulations | |
CN106022521A (zh) | 基于Hadoop架构的分布式BP神经网络的短期负荷预测方法 | |
GB2579789A (en) | Runtime parameter selection in simulations | |
GB2590238A (en) | Automated rate of penetration optimization for drilling | |
CN106843172A (zh) | 基于jy‑kpls的复杂工业过程在线质量预测方法 | |
GB2590768A8 (en) | Method for optimizing motion parameter of industrial robot for energy saving in big data environment | |
ATE295557T1 (de) | Verfahren zur steuerung und/oder regelung eines technischen prozesses | |
CN104318090A (zh) | 基于最小二乘法支持向量机的溶菌酶发酵过程中的广义预测方法 | |
CN110163409A (zh) | 一种应用于置换流水车间的卷积神经网络调度方法 | |
CN109143853B (zh) | 一种石油炼化过程中分馏塔液位自适应控制方法 | |
CN103792845B (zh) | 一种金霉素发酵过程补糖速率优化控制的方法和*** | |
CN103955173B (zh) | 一种保持炼钢-连铸生产稳定性的在线控制方法及*** | |
CN105652666B (zh) | 基于bp神经网络的大型模锻压机上横梁速度预测控制方法 | |
SG11201805349YA (en) | Robot and method for operating a robot | |
CN106605179A (zh) | 预测值整形***、控制***、预测值整形方法、控制方法及预测值整形程序 | |
US20200379452A1 (en) | Plant operating condition setting support system, learning device, and operating condition setting support device | |
CN113848711A (zh) | 一种基于安全模型强化学习的数据中心制冷控制算法 | |
CN106094524A (zh) | 基于输入趋势补偿的快速模型预测控制方法 | |
WO2020257335A8 (en) | System and method for centralized fluid management and culture control | |
WO2021050379A3 (en) | Nuclear control system with neural network | |
Balula et al. | Sequential quadratic programming-based iterative learning control for nonlinear systems | |
CN113657742A (zh) | 车间调度方法、装置、电子设备及存储介质 | |
CN109001981B (zh) | 一种污水处理的强化学习控制方法 |