MX2023003041A - Métodos para administrar dosis terapéuticas de moléculas de acoplamiento a células t biespecíficas para el tratamiento de cáncer. - Google Patents

Métodos para administrar dosis terapéuticas de moléculas de acoplamiento a células t biespecíficas para el tratamiento de cáncer.

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Publication number
MX2023003041A
MX2023003041A MX2023003041A MX2023003041A MX2023003041A MX 2023003041 A MX2023003041 A MX 2023003041A MX 2023003041 A MX2023003041 A MX 2023003041A MX 2023003041 A MX2023003041 A MX 2023003041A MX 2023003041 A MX2023003041 A MX 2023003041A
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Mexico
Prior art keywords
bispecific
cell engaging
methods
cancer
treatment
Prior art date
Application number
MX2023003041A
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English (en)
Inventor
Peter Kufer
Dirk Nagorsen
Adam B Mccullough
Vijay Upreti
Hosein Kouros-Mehr
Mark Salvati
Alexander C Minella
Mukul Minocha
Brett Houk
Original Assignee
Amgen Inc
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Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MX2023003041A publication Critical patent/MX2023003041A/es

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    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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Abstract

La presente invención se refiere a métodos para administrar dosis terapéuticas de moléculas de acoplamiento a células T biespecíficas para el tratamiento de cáncer en un paciente. Los métodos de administración reducen la incidencia y/o intensidad de acontecimientos adversos, tales como síndrome de liberación de citocinas, y conllevan administrar a un paciente una dosis de cebado de la molécula de acoplamiento a células T biespecífica mediante infusión intravenosa continua a lo largo de un periodo de días seguido por la administración de una dosis terapéutica de la molécula de acoplamiento a células T biespecífica mediante una infusión intravenosa en bolo a intervalos de dosificación de al menos una semana.
MX2023003041A 2020-09-16 2021-09-15 Métodos para administrar dosis terapéuticas de moléculas de acoplamiento a células t biespecíficas para el tratamiento de cáncer. MX2023003041A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063079418P 2020-09-16 2020-09-16
PCT/US2021/050546 WO2022060901A1 (en) 2020-09-16 2021-09-15 Methods for administering therapeutic doses of bispecific t-cell engaging molecules for the treatment of cancer

Publications (1)

Publication Number Publication Date
MX2023003041A true MX2023003041A (es) 2023-05-09

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MX2023003041A MX2023003041A (es) 2020-09-16 2021-09-15 Métodos para administrar dosis terapéuticas de moléculas de acoplamiento a células t biespecíficas para el tratamiento de cáncer.

Country Status (9)

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US (1) US20230398147A1 (es)
EP (1) EP4214233A1 (es)
JP (1) JP2023542257A (es)
CN (1) CN116829183A (es)
AU (1) AU2021345124A1 (es)
CA (1) CA3194771A1 (es)
MX (1) MX2023003041A (es)
TW (1) TW202222823A (es)
WO (1) WO2022060901A1 (es)

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EP4214233A1 (en) 2023-07-26
JP2023542257A (ja) 2023-10-05
CA3194771A1 (en) 2022-03-24
US20230398147A1 (en) 2023-12-14
TW202222823A (zh) 2022-06-16
CN116829183A (zh) 2023-09-29
WO2022060901A1 (en) 2022-03-24

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