MX2022015003A - Formas de dosificacion oral solidas de combinacion de antagonistas de la hormona liberadora de gonadotropina. - Google Patents
Formas de dosificacion oral solidas de combinacion de antagonistas de la hormona liberadora de gonadotropina.Info
- Publication number
- MX2022015003A MX2022015003A MX2022015003A MX2022015003A MX2022015003A MX 2022015003 A MX2022015003 A MX 2022015003A MX 2022015003 A MX2022015003 A MX 2022015003A MX 2022015003 A MX2022015003 A MX 2022015003A MX 2022015003 A MX2022015003 A MX 2022015003A
- Authority
- MX
- Mexico
- Prior art keywords
- dosage forms
- oral dosage
- solid oral
- gonadotropin
- releasing hormone
- Prior art date
Links
- 239000006186 oral dosage form Substances 0.000 title abstract 3
- 239000007787 solid Substances 0.000 title abstract 3
- 239000000579 Gonadotropin-Releasing Hormone Substances 0.000 title 1
- 101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 title 1
- 229940035638 gonadotropin-releasing hormone Drugs 0.000 title 1
- -1 4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-metho xy-3-pyridazinyl)-2,4-dioxo- 1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/2853—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers, poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2893—Tablet coating processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
Abstract
La presente descripción incluye formas de dosificación oral sólidas de combinación que tienen 40 mg de N-(4-(1-(2,6-difluorobe ncil)-5-((dimetilamino)metil)-3-(6-metoxi-3-piridazinil)-2,4-diox o-1,2,3,4-tetrahidrotieno[2,3-d]pirimidin-6-il)fenil)-N'-metoxiur ea, o una cantidad correspondiente de una sal farmacéuticamente aceptable de esta, y medicamentos de reemplazo hormonal; también se proporcionan procesos para elaborar y usar las formas de dosificación oral sólidas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063032469P | 2020-05-29 | 2020-05-29 | |
PCT/EP2021/064280 WO2021239917A1 (en) | 2020-05-29 | 2021-05-27 | Combination solid oral dosage forms of gonadotropin-releasing hormone antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022015003A true MX2022015003A (es) | 2023-03-03 |
Family
ID=76305879
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022015003A MX2022015003A (es) | 2020-05-29 | 2021-05-27 | Formas de dosificacion oral solidas de combinacion de antagonistas de la hormona liberadora de gonadotropina. |
Country Status (17)
Country | Link |
---|---|
US (1) | US20230165800A1 (es) |
EP (1) | EP4157227A1 (es) |
JP (1) | JP2023528014A (es) |
KR (1) | KR20230028732A (es) |
CN (1) | CN115666531A (es) |
AR (1) | AR122175A1 (es) |
AU (1) | AU2021278303A1 (es) |
BR (1) | BR112022023937A2 (es) |
CA (1) | CA3185151A1 (es) |
CL (1) | CL2022003338A1 (es) |
CO (1) | CO2022019160A2 (es) |
EC (1) | ECSP22098275A (es) |
IL (1) | IL298587A (es) |
MX (1) | MX2022015003A (es) |
PE (1) | PE20230859A1 (es) |
UY (1) | UY39229A (es) |
WO (1) | WO2021239917A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RS63300B1 (sr) | 2016-09-30 | 2022-07-29 | Myovant Sciences Gmbh | Postupci lečenja fibroida materice i endometrioze |
CN115227648B (zh) * | 2022-08-03 | 2023-09-29 | 南昌大学 | 一种瑞卢戈利固体自微乳及其制备方法和应用 |
CN115068421B (zh) * | 2022-08-03 | 2023-08-04 | 南昌大学 | 一种瑞卢戈利纳米混悬液及其制备方法和应用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0407082C1 (pt) | 2003-01-29 | 2021-05-25 | Takeda Pharmaceuticals Co | composto n-(4-(1-(2,6-difluorobenzil)-5-((dimetilamino)metil)-3-(6-metóxi-3-piridazinil)-2,4-dioxo-1,2,3,4-tetraidrotieno[2,3-d]pirimidina-6-il)fenil)-n-metoxiuréia, ou um sal do mesmo, produto farmacêutico, e, uso do composto |
DK3415517T3 (da) | 2012-09-28 | 2022-05-30 | Takeda Pharmaceuticals Co | Krystallinsk form af 1-(4-1-(2,6-difluorbenzyl)-5-dimethylaminomethyl-3-(6- methoxypyridazin-3-yl)-2,4-dioxo-1,2,3,4-tetrahydrothieno(2,3-d)-pyrimidin- 6yl)phenyl)-3-methoxyurea |
MY180680A (en) | 2015-02-26 | 2020-12-06 | Takeda Pharmaceuticals Co | Solid preparation |
RS63300B1 (sr) | 2016-09-30 | 2022-07-29 | Myovant Sciences Gmbh | Postupci lečenja fibroida materice i endometrioze |
EP3518932A2 (en) | 2016-09-30 | 2019-08-07 | Myovant Sciences GmbH | Treatment of prostate cancer |
-
2021
- 2021-05-27 AR ARP210101422A patent/AR122175A1/es unknown
- 2021-05-27 MX MX2022015003A patent/MX2022015003A/es unknown
- 2021-05-27 AU AU2021278303A patent/AU2021278303A1/en active Pending
- 2021-05-27 PE PE2022002787A patent/PE20230859A1/es unknown
- 2021-05-27 IL IL298587A patent/IL298587A/en unknown
- 2021-05-27 WO PCT/EP2021/064280 patent/WO2021239917A1/en unknown
- 2021-05-27 JP JP2022572798A patent/JP2023528014A/ja active Pending
- 2021-05-27 UY UY0001039229A patent/UY39229A/es unknown
- 2021-05-27 BR BR112022023937A patent/BR112022023937A2/pt unknown
- 2021-05-27 CN CN202180037887.XA patent/CN115666531A/zh active Pending
- 2021-05-27 CA CA3185151A patent/CA3185151A1/en active Pending
- 2021-05-27 EP EP21730501.0A patent/EP4157227A1/en active Pending
- 2021-05-27 KR KR1020227046030A patent/KR20230028732A/ko active Search and Examination
-
2022
- 2022-11-25 CL CL2022003338A patent/CL2022003338A1/es unknown
- 2022-11-28 US US18/070,341 patent/US20230165800A1/en active Pending
- 2022-12-28 CO CONC2022/0019160A patent/CO2022019160A2/es unknown
- 2022-12-29 EC ECSENADI202298275A patent/ECSP22098275A/es unknown
Also Published As
Publication number | Publication date |
---|---|
BR112022023937A2 (pt) | 2022-12-27 |
CN115666531A (zh) | 2023-01-31 |
JP2023528014A (ja) | 2023-07-03 |
AR122175A1 (es) | 2022-08-24 |
CA3185151A1 (en) | 2021-12-02 |
WO2021239917A1 (en) | 2021-12-02 |
EP4157227A1 (en) | 2023-04-05 |
US20230165800A1 (en) | 2023-06-01 |
ECSP22098275A (es) | 2023-01-31 |
CO2022019160A2 (es) | 2023-03-27 |
KR20230028732A (ko) | 2023-03-02 |
PE20230859A1 (es) | 2023-05-30 |
UY39229A (es) | 2021-12-31 |
IL298587A (en) | 2023-01-01 |
AU2021278303A1 (en) | 2023-02-09 |
CL2022003338A1 (es) | 2023-06-30 |
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