MX2022012821A - Metodos de conjugacion de diels-alder. - Google Patents

Metodos de conjugacion de diels-alder.

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Publication number
MX2022012821A
MX2022012821A MX2022012821A MX2022012821A MX2022012821A MX 2022012821 A MX2022012821 A MX 2022012821A MX 2022012821 A MX2022012821 A MX 2022012821A MX 2022012821 A MX2022012821 A MX 2022012821A MX 2022012821 A MX2022012821 A MX 2022012821A
Authority
MX
Mexico
Prior art keywords
diels
alder
antibody
compositions
conjugation methods
Prior art date
Application number
MX2022012821A
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English (en)
Inventor
Thomas Nittoli
Original Assignee
Regeneron Pharma
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Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of MX2022012821A publication Critical patent/MX2022012821A/es

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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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Abstract

En el presente documento se describen conjugados de proteína-carga útil y composiciones de los mismos que son útiles, por ejemplo, para la administración específica de objetivos de porciones de agentes terapéuticos y/o de formación de imágenes. En ciertas modalidades, se proveen métodos específicos y eficaces para producir construcciones de proteína-carga útil (p. ej., conjugados de anticuerpo-fármaco) utilizando una combinación de técnicas de transglutaminasa y de Diels-Alder. Se proveen conjugados y composiciones de anticuerpo-fármaco que comprenden anticuerpos modificados con glutaminilo, aductos de Diels-Alder y cargas útiles reactivas.
MX2022012821A 2020-04-16 2021-04-16 Metodos de conjugacion de diels-alder. MX2022012821A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063010903P 2020-04-16 2020-04-16
PCT/US2021/027707 WO2021211984A1 (en) 2020-04-16 2021-04-16 Diels-alder conjugation methods

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MX2022012821A true MX2022012821A (es) 2022-11-07

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US (1) US11701427B2 (es)
EP (1) EP4135775A1 (es)
JP (1) JP2023521885A (es)
KR (1) KR20230004651A (es)
CN (1) CN115968304A (es)
AU (1) AU2021255711A1 (es)
CA (1) CA3179154A1 (es)
IL (1) IL297027A (es)
MX (1) MX2022012821A (es)
WO (1) WO2021211984A1 (es)

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