MX2022007672A - Anticuerpos del receptor alfa de interleucina-4 canina. - Google Patents

Anticuerpos del receptor alfa de interleucina-4 canina.

Info

Publication number
MX2022007672A
MX2022007672A MX2022007672A MX2022007672A MX2022007672A MX 2022007672 A MX2022007672 A MX 2022007672A MX 2022007672 A MX2022007672 A MX 2022007672A MX 2022007672 A MX2022007672 A MX 2022007672A MX 2022007672 A MX2022007672 A MX 2022007672A
Authority
MX
Mexico
Prior art keywords
receptor alpha
canine
alpha antibodies
antibodies
canine interleukin
Prior art date
Application number
MX2022007672A
Other languages
English (en)
Inventor
Mohamad Morsey
Yuanzheng Zhang
Original Assignee
Intervet Int Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intervet Int Bv filed Critical Intervet Int Bv
Publication of MX2022007672A publication Critical patent/MX2022007672A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Abstract

La presente invención proporciona anticuerpos contra el receptor alfa de IL-4 canina que tienen una alta afinidad de unión para el receptor alfa de IL-4 canina, y que pueden bloquear la unión de la IL-4 y/o la IL-13 canina al receptor alfa de IL-4 canina. La presente invención además se refiere a epítopos del receptor alfa de IL-4 que se unen a los anticuerpos contra el receptor alfa de IL-4 canina. La presente invención además proporciona el uso de los anticuerpos para el tratamiento de la dermatitis atópica en perros.
MX2022007672A 2019-12-20 2020-12-18 Anticuerpos del receptor alfa de interleucina-4 canina. MX2022007672A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962951793P 2019-12-20 2019-12-20
US201962951778P 2019-12-20 2019-12-20
US202063015220P 2020-04-24 2020-04-24
US202063015209P 2020-04-24 2020-04-24
PCT/EP2020/086921 WO2021123091A1 (en) 2019-12-20 2020-12-18 Canine interleukin-4 receptor alpha antibodies

Publications (1)

Publication Number Publication Date
MX2022007672A true MX2022007672A (es) 2022-07-19

Family

ID=74183109

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2022007672A MX2022007672A (es) 2019-12-20 2020-12-18 Anticuerpos del receptor alfa de interleucina-4 canina.
MX2022007677A MX2022007677A (es) 2019-12-20 2020-12-18 Anticuerpos para receptor alfa de interleucina-4 canino.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2022007677A MX2022007677A (es) 2019-12-20 2020-12-18 Anticuerpos para receptor alfa de interleucina-4 canino.

Country Status (9)

Country Link
US (2) US20230044037A1 (es)
EP (2) EP4076653A1 (es)
JP (2) JP2023506923A (es)
CN (2) CN114867526A (es)
AU (2) AU2020409583A1 (es)
BR (2) BR112022012203A2 (es)
CA (2) CA3160589A1 (es)
MX (2) MX2022007672A (es)
WO (2) WO2021123089A1 (es)

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US4487603A (en) 1982-11-26 1984-12-11 Cordis Corporation Implantable microinfusion pump system
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4596556A (en) 1985-03-25 1986-06-24 Bioject, Inc. Hypodermic injection apparatus
CA1319120C (en) 1985-04-01 1993-06-15 John Henry Kenten Transformed myeloma cell-line and a process for the expression of a gene coding for a eukaryotic polypeptide employing same
GB8601597D0 (en) 1986-01-23 1986-02-26 Wilson R H Nucleotide sequences
US4790824A (en) 1987-06-19 1988-12-13 Bioject, Inc. Non-invasive hypodermic injection device
US4941880A (en) 1987-06-19 1990-07-17 Bioject, Inc. Pre-filled ampule and non-invasive hypodermic injection device assembly
GB8717430D0 (en) 1987-07-23 1987-08-26 Celltech Ltd Recombinant dna product
US5312335A (en) 1989-11-09 1994-05-17 Bioject Inc. Needleless hypodermic injection device
US5064413A (en) 1989-11-09 1991-11-12 Bioject, Inc. Needleless hypodermic injection device
US5383851A (en) 1992-07-24 1995-01-24 Bioject Inc. Needleless hypodermic injection device
GB9818110D0 (en) 1998-08-19 1998-10-14 Weston Medical Ltd Needleless injectors and other devices
US6096002A (en) 1998-11-18 2000-08-01 Bioject, Inc. NGAS powered self-resetting needle-less hypodermic jet injection apparatus and method
PT1914244E (pt) 1999-04-09 2013-07-26 Kyowa Hakko Kirin Co Ltd Processo para regular a actividade de moléculas funcionais sob o ponto de vista imunológico
US6946292B2 (en) 2000-10-06 2005-09-20 Kyowa Hakko Kogyo Co., Ltd. Cells producing antibody compositions with increased antibody dependent cytotoxic activity
WO2005032399A2 (en) 2003-05-30 2005-04-14 The Regents Of The University Of California Il4 receptor antagonists for horse, dog and cat
US8790651B2 (en) 2011-07-21 2014-07-29 Zoetis Llc Interleukin-31 monoclonal antibody
TWI682781B (zh) 2013-07-11 2020-01-21 美商再生元醫藥公司 藉由投與ｉｌ－４ｒ抑制劑治療嗜酸性食道炎的方法
CN105829344B (zh) 2013-12-20 2021-12-07 英特维特国际股份有限公司 犬化鼠抗犬pd-1抗体
JP6938383B2 (ja) 2015-04-02 2021-09-22 インターベット インターナショナル ベー． フェー． イヌインターロイキン４受容体アルファに対する抗体
EP3390451A1 (en) * 2015-12-18 2018-10-24 Intervet International B.V. Caninized human antibodies to human and canine il-4ralpha
US10093731B2 (en) 2017-02-24 2018-10-09 Kindred Biosciences, Inc. Anti-IL31 antibodies for veterinary use

Also Published As

Publication number Publication date
EP4076653A1 (en) 2022-10-26
CN114867526A (zh) 2022-08-05
MX2022007677A (es) 2022-07-19
EP4077390A1 (en) 2022-10-26
US20230053131A1 (en) 2023-02-16
JP2023506923A (ja) 2023-02-20
CA3162031A1 (en) 2021-06-24
CN114929746A (zh) 2022-08-19
BR112022011797A2 (pt) 2022-08-30
WO2021123091A1 (en) 2021-06-24
CA3160589A1 (en) 2021-06-24
WO2021123089A1 (en) 2021-06-24
AU2020409583A1 (en) 2022-06-09
AU2020407853A1 (en) 2022-06-09
US20230044037A1 (en) 2023-02-09
JP2023506924A (ja) 2023-02-20
BR112022012203A2 (pt) 2022-09-13

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