MX2022007389A - Remocion del conservante de las gotas para los ojos. - Google Patents

Remocion del conservante de las gotas para los ojos.

Info

Publication number
MX2022007389A
MX2022007389A MX2022007389A MX2022007389A MX2022007389A MX 2022007389 A MX2022007389 A MX 2022007389A MX 2022007389 A MX2022007389 A MX 2022007389A MX 2022007389 A MX2022007389 A MX 2022007389A MX 2022007389 A MX2022007389 A MX 2022007389A
Authority
MX
Mexico
Prior art keywords
eye drops
preservative
preservative removal
drug
fatty acid
Prior art date
Application number
MX2022007389A
Other languages
English (en)
Inventor
Michael S Williams
Deniz Hay
Michael Malanga
Original Assignee
Tearclear Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tearclear Corp filed Critical Tearclear Corp
Publication of MX2022007389A publication Critical patent/MX2022007389A/es

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • B01J20/265—Synthetic macromolecular compounds modified or post-treated polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1443—Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters
    • A61J1/1456—Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters using liquid filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1475—Inlet or outlet ports
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
    • B01D67/0002—Organic membrane manufacture
    • B01D67/0004—Organic membrane manufacture by agglomeration of particles
    • B01D67/00043—Organic membrane manufacture by agglomeration of particles by agglomeration of nanoparticles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/14—Dynamic membranes
    • B01D69/141—Heterogeneous membranes, e.g. containing dispersed material; Mixed matrix membranes
    • B01D69/147—Heterogeneous membranes, e.g. containing dispersed material; Mixed matrix membranes containing embedded adsorbents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/26—Polyalkenes
    • B01D71/261—Polyethylene
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28016—Particle form
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28042—Shaped bodies; Monolithic structures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/20—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
    • B01D15/206—Packing or coating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00—Aspects relating to sorbent materials
    • B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
    • B01J2220/52—Sorbents specially adapted for preparative chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00—Aspects relating to sorbent materials
    • B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
    • B01J2220/56—Use in the form of a bed
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6004—Construction of the column end pieces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Manufacturing & Machinery (AREA)
  • Nanotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se presenta un tapón con partículas para remover un conservante de una solución, suspensión o emulsión que comprende un fármaco. El tapón comprende micropartículas de una mezcla de polímero hidrofóbico/ácido graso. Las micropartículas de la mezcla de polímero hidrofóbico/ácido graso absorben selectivamente el conservante, lo que permite que el fármaco permanezca en solución para su entrega.
MX2022007389A 2019-12-19 2020-12-18 Remocion del conservante de las gotas para los ojos. MX2022007389A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962950866P 2019-12-19 2019-12-19
PCT/US2020/066216 WO2021127564A1 (en) 2019-12-19 2020-12-18 Preservative removal from eye drops

Publications (1)

Publication Number Publication Date
MX2022007389A true MX2022007389A (es) 2022-08-10

Family

ID=76478831

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022007389A MX2022007389A (es) 2019-12-19 2020-12-18 Remocion del conservante de las gotas para los ojos.

Country Status (10)

Country Link
US (2) US11179294B2 (es)
EP (1) EP4076302A4 (es)
JP (1) JP2023516534A (es)
KR (1) KR20220144359A (es)
CN (1) CN115397374A (es)
AU (1) AU2020405238A1 (es)
CA (1) CA3165110A1 (es)
IL (1) IL293976A (es)
MX (1) MX2022007389A (es)
WO (1) WO2021127564A1 (es)

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3293112A (en) 1963-05-06 1966-12-20 Grace W R & Co Amino-cross linked oxidized alpha-olefin polymer
US3322711A (en) 1963-10-17 1967-05-30 Allied Chem Polymer oxidation process and emulsion therefrom
DE1570652A1 (de) 1964-03-09 1970-03-26 Allied Chem Verfahren zur Herstellung von oxydiertem Polyaethylen
DE3112163A1 (de) 1981-03-27 1982-10-14 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung von emulgierbarem polyethylen durch oxidation von polyethylen im wirbelbettreaktor
DE3720953A1 (de) 1987-06-25 1989-01-05 Basf Ag Verfahren zur oxidation von polyethylen
US5056689A (en) 1990-01-08 1991-10-15 Ciba-Geigy Corporation Apparatus for removing components from solutions
US5080800A (en) 1990-01-08 1992-01-14 Ciba-Geigy Corporation Process for removing components from solutions
JP3468568B2 (ja) 1993-03-31 2003-11-17 川田 武豊 携帯用液体浄化器
DE69411816T2 (de) 1993-06-25 1998-12-03 Alcon Cusi S A Neue Verwendung von polymeren Membranen zum Ausgeben von pharmazeutischen Lösungen, die quarternäre, als Konserviermittel dienende Ammoniumverbindungen enthalten und entsprechender Dosierbehälter
US5401811A (en) 1994-05-03 1995-03-28 Eastman Chemical Company Continuous process for the oxidation of polyethylene
US5611464A (en) 1995-05-30 1997-03-18 Ciba Geigy Corporation Container for preserving media in the tip of a solution dispenser
SE505274C2 (sv) 1995-10-24 1997-07-28 Sten Andersson Användning av en hydrofob zeolit för avlägsnande av för injektionslösningar i läkemedelssammanhang använda konserveringsmedel från en proteinlösning
US7611831B2 (en) 1998-01-06 2009-11-03 Cerus Corporation Adsorbing pathogen-inactivating compounds with porous particles immobilized in a matrix
US6669848B2 (en) 2002-01-31 2003-12-30 Tillin, Inc. Methods of treating commercial grade preservatives to remove undesirable odors and flavors
US6713646B2 (en) 2002-04-12 2004-03-30 Biosphere Medical Degradable crosslinkers, and degradable crosslinked hydrogels comprising them
US7030149B2 (en) 2002-04-19 2006-04-18 Allergan, Inc. Combination of brimonidine timolol for topical ophthalmic use
WO2005066219A1 (en) 2003-04-01 2005-07-21 Honeywell International Inc. Process for oxidizing linear low molecular weight polyethylene
US6933289B2 (en) 2003-07-01 2005-08-23 Allergan, Inc. Inhibition of irritating side effects associated with use of a topical ophthalmic medication
BRPI0414025A (pt) 2003-09-02 2006-10-24 Otsuka Pharma Co Ltd dispositivo de distribuição, recipiente de distribuição e conta-gotas dotados com o mesmo
CA2670749A1 (en) 2006-12-05 2008-06-12 Landec Corporation Drug delivery
US7622031B2 (en) 2007-01-15 2009-11-24 Honeywell International Inc Method for preparing oxidized polyolefin waxes
MX2010001629A (es) 2007-08-10 2010-08-09 Alessandro Sannino Hidrogeles de polimero y metodos de preparacion de los mismos.
WO2009032266A2 (en) 2007-09-04 2009-03-12 University Of Florida Dispersions of microparticles and microgels in hydrogels for drug delivery
IL187203A (en) 2007-11-06 2015-03-31 Aphelion Ltd Contaminant Detection / Detection Matrix
US20100285192A1 (en) 2008-01-29 2010-11-11 Universite Catholique De Louvain Method for filtering a liquid
EP2435526A4 (en) 2009-05-29 2012-10-31 Exxonmobil Chem Patents Inc POLYOLEFINIC ADHESIVE COMPOSITIONS AND PROCESS FOR PRODUCING THE SAME
JP5923942B2 (ja) 2011-11-18 2016-05-25 日立化成株式会社 半導体封止用エポキシ樹脂組成物およびそれを用いた半導体装置
CA3144684A1 (en) 2013-03-05 2014-09-12 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Thermoresponsive hydrogel containing polymer microparticles for noninvasive ocular drug delivery
GB2544213B (en) 2014-08-13 2017-09-27 Univ Florida Preservative removal from eye drops
AU2015353701B2 (en) * 2014-11-25 2021-03-25 Allergan, Inc. Stabilized omega-3 ophthalmic compositions
WO2017096203A1 (en) 2015-12-04 2017-06-08 Poly-Med, Inc. Double network hydrogel with anionic polymer and uses thereof
EP3473116A4 (en) * 2016-07-04 2020-02-26 Japan Tobacco Inc. ADSORBENT, FILTER FOR SMOKING PRODUCT PROVIDED WITH SUCH ADSORBENT, AND SMOKING PRODUCT PROVIDED WITH SUCH FILTER FOR SMOKING PRODUCTS
US11654379B2 (en) * 2016-10-20 2023-05-23 Mycelx Technologies Corporation Granular media for backwashable particle filter and free phase oil coalescer
AU2017366761B2 (en) 2016-12-02 2023-06-15 University Of Florida Research Foundation, Inc. Preservative removal from eye drops
CN116392389A (zh) * 2017-09-25 2023-07-07 佛罗里达大学研究基金会股份有限公司 从含亲水药物的滴眼剂中除去防腐剂
TW202005623A (zh) * 2018-04-06 2020-02-01 美商蒂克利爾公司 用於輸送治療劑之系統及方法
JP2022519580A (ja) * 2019-02-06 2022-03-24 ティアークリアー コープ． 複合体化剤を含む眼科用製剤から防腐剤を除去するためのシステムおよび方法
US11723838B2 (en) * 2019-05-02 2023-08-15 TearClear Corp. Preservative removal from eye drops

Also Published As

Publication number Publication date
US20210196569A1 (en) 2021-07-01
WO2021127564A1 (en) 2021-06-24
EP4076302A4 (en) 2024-01-10
US11179294B2 (en) 2021-11-23
KR20220144359A (ko) 2022-10-26
CN115397374A (zh) 2022-11-25
IL293976A (en) 2022-08-01
US20220040037A1 (en) 2022-02-10
EP4076302A1 (en) 2022-10-26
CA3165110A1 (en) 2021-06-24
AU2020405238A1 (en) 2022-07-14
JP2023516534A (ja) 2023-04-20

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