MX2022004705A - Procesamiento y producción aséptica de células sin biocidas químicos. - Google Patents
Procesamiento y producción aséptica de células sin biocidas químicos.Info
- Publication number
- MX2022004705A MX2022004705A MX2022004705A MX2022004705A MX2022004705A MX 2022004705 A MX2022004705 A MX 2022004705A MX 2022004705 A MX2022004705 A MX 2022004705A MX 2022004705 A MX2022004705 A MX 2022004705A MX 2022004705 A MX2022004705 A MX 2022004705A
- Authority
- MX
- Mexico
- Prior art keywords
- enclosure
- production
- cell processing
- chemical biocides
- less
- Prior art date
Links
- 239000003139 biocide Substances 0.000 title abstract 2
- 239000000126 substance Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 238000012865 aseptic processing Methods 0.000 abstract 1
- 230000001332 colony forming effect Effects 0.000 abstract 1
- 238000011109 contamination Methods 0.000 abstract 1
- 230000007613 environmental effect Effects 0.000 abstract 1
- 230000000813 microbial effect Effects 0.000 abstract 1
- 238000012544 monitoring process Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
- C12M37/04—Seals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
- C12M41/34—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of gas
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
- C12M41/36—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of biomass, e.g. colony counters or by turbidity measurements
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M45/00—Means for pre-treatment of biological substances
- C12M45/03—Means for pre-treatment of biological substances by control of the humidity or content of liquids; Drying
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0081—Purging biological preparations of unwanted cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/22—Testing for sterility conditions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/02—Atmosphere, e.g. low oxygen conditions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2523/00—Culture process characterised by temperature
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Sustainable Development (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Thermal Sciences (AREA)
- Cell Biology (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La presente invención se refiere a un método y aparato de procesamiento y producción aséptica de células en un aparato de recinto no estéril sin biocidas químicos, mediante el control del nivel de humedad en todo el recinto a 25 % de humedad relativa (HR) o menos, y preferentemente a 20 % o 15 % o menos de HR. Además, la temperatura se controla a 37 °C y se mantiene un flujo de gas constante en el recinto. Las unidades formadoras de colonias a partir de la contaminación microbiana detectada por el monitoreo ambiental dentro del recinto se reducen significativamente con este método.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962924322P | 2019-10-22 | 2019-10-22 | |
PCT/US2020/056836 WO2021081188A1 (en) | 2019-10-22 | 2020-10-22 | Aseptic cell processing and production with no chemical biocides |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022004705A true MX2022004705A (es) | 2023-02-14 |
Family
ID=75620303
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022004705A MX2022004705A (es) | 2019-10-22 | 2020-10-22 | Procesamiento y producción aséptica de células sin biocidas químicos. |
Country Status (11)
Country | Link |
---|---|
US (2) | US11326140B2 (es) |
EP (1) | EP4048775A4 (es) |
JP (1) | JP7409717B2 (es) |
KR (1) | KR102596110B1 (es) |
CN (1) | CN114945658B (es) |
AU (1) | AU2020370270B2 (es) |
BR (1) | BR112022007106A2 (es) |
CA (1) | CA3150905A1 (es) |
IL (1) | IL292223B2 (es) |
MX (1) | MX2022004705A (es) |
WO (1) | WO2021081188A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP4048775A4 (en) * | 2019-10-22 | 2023-07-26 | Biospherix Ltd. | ASEPTIC CELL PROCESSING AND PRODUCTION WITHOUT CHEMICAL BIOCIDES |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3203002B2 (ja) * | 1991-01-23 | 2001-08-27 | カヤバ工業株式会社 | 位置制御装置 |
US5482684A (en) * | 1994-05-03 | 1996-01-09 | Abtox, Inc. | Vessel useful for monitoring plasma sterilizing processes |
US6297047B1 (en) * | 1999-08-25 | 2001-10-02 | Spx Corporation | Ultraviolet sterilization of CO2 cell-culture incubator internal environments |
US20030092178A1 (en) * | 2001-11-15 | 2003-05-15 | Biospherix, Ltd. | Cell culture incubator with dynamic oxygen control |
EP1552888B1 (de) * | 2004-01-06 | 2010-01-20 | Thermo Electron LED GmbH | Klimagerät mit keimdicht abgetrennten Bereichen |
JP4606971B2 (ja) | 2005-08-19 | 2011-01-05 | 株式会社エヌ・ティ・ティ・ドコモ | チケット流通仲介装置、チケット流通仲介システム、及びチケット流通仲介方法 |
KR20080072022A (ko) * | 2005-11-01 | 2008-08-05 | 가부시키가이샤 메디넷 | 세포배양장치, 세포배양방법, 세포배양프로그램, 및세포배양시스템 |
WO2010047672A1 (en) | 2008-10-20 | 2010-04-29 | Rao Chamkurkishtiah P | Self-cleaning and sterilizing endotracheal and tracheostomy tube |
EP2571534B1 (en) | 2010-05-20 | 2018-10-10 | Automatic Bar Controls, Inc. | Ultraviolet disinfecting device for beverage dispensers |
US9056148B2 (en) | 2010-10-27 | 2015-06-16 | University Of Florida Research Foundation, Inc. | Method and apparatus for disinfecting and/or self-sterilizing a stethoscope using plasma energy |
JP5852792B2 (ja) * | 2011-04-28 | 2016-02-03 | パナソニックヘルスケアホールディングス株式会社 | アイソレータ、培養物の移動方法 |
KR20120124153A (ko) * | 2011-05-03 | 2012-11-13 | 한신메디칼 주식회사 | 건열 멸균 배양 장치 |
BR112014031781A2 (pt) * | 2012-06-22 | 2017-08-01 | Suganit Systems Inc | método e aparelho para tratamento de substratos de biomassa |
JP6121299B2 (ja) * | 2013-09-25 | 2017-04-26 | 東京エレクトロン株式会社 | 自動培養システム及び自動培養装置 |
KR101656732B1 (ko) * | 2015-03-05 | 2016-09-19 | 한소 주식회사 | 멸균 방법 및 이를 이용한 장치 |
EP3307864B1 (en) * | 2015-03-31 | 2024-02-28 | Thrive Bioscience, Inc. | Cell culture incubator and cell culture method |
JP2019013151A (ja) * | 2015-11-27 | 2019-01-31 | 東京エレクトロン株式会社 | 細胞培養システム |
JP3203002U (ja) * | 2015-12-21 | 2016-03-03 | バイオメディカ・ソリューション株式会社 | 細胞培養システム |
KR101912197B1 (ko) * | 2017-02-22 | 2018-10-26 | 주식회사 이뮤니스바이오 | 무인무균 자동 세포 배양 장치 |
JP6886693B2 (ja) * | 2017-05-15 | 2021-06-16 | 株式会社エアレックス | インキュベータ |
JP6409237B1 (ja) * | 2017-06-14 | 2018-10-24 | 株式会社伸光テクノス | 加水分解処理装置及び加水分解処理システム |
JP2021529312A (ja) * | 2018-07-03 | 2021-10-28 | アドバンスト・ソリューションズ・ライフ・サイエンシズ,エルエルシー | 1つまたは複数の標本の灌流および/または定温放置のためのモジュール式保管ユニット、および保管庫組立体 |
EP4048775A4 (en) * | 2019-10-22 | 2023-07-26 | Biospherix Ltd. | ASEPTIC CELL PROCESSING AND PRODUCTION WITHOUT CHEMICAL BIOCIDES |
-
2020
- 2020-10-22 EP EP20879105.3A patent/EP4048775A4/en active Pending
- 2020-10-22 JP JP2022523273A patent/JP7409717B2/ja active Active
- 2020-10-22 IL IL292223A patent/IL292223B2/en unknown
- 2020-10-22 KR KR1020227016801A patent/KR102596110B1/ko active IP Right Grant
- 2020-10-22 CN CN202080073132.0A patent/CN114945658B/zh active Active
- 2020-10-22 AU AU2020370270A patent/AU2020370270B2/en active Active
- 2020-10-22 MX MX2022004705A patent/MX2022004705A/es unknown
- 2020-10-22 WO PCT/US2020/056836 patent/WO2021081188A1/en unknown
- 2020-10-22 BR BR112022007106A patent/BR112022007106A2/pt unknown
- 2020-10-22 CA CA3150905A patent/CA3150905A1/en active Pending
-
2021
- 2021-02-19 US US17/179,468 patent/US11326140B2/en active Active
-
2022
- 2022-04-18 US US17/658,439 patent/US20220235310A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
KR20220104704A (ko) | 2022-07-26 |
US20210171894A1 (en) | 2021-06-10 |
EP4048775A4 (en) | 2023-07-26 |
CN114945658B (zh) | 2023-05-16 |
CA3150905A1 (en) | 2021-04-29 |
AU2020370270B2 (en) | 2024-01-11 |
IL292223B1 (en) | 2023-07-01 |
IL292223B2 (en) | 2023-11-01 |
JP7409717B2 (ja) | 2024-01-09 |
IL292223A (en) | 2022-06-01 |
BR112022007106A2 (pt) | 2022-08-02 |
KR102596110B1 (ko) | 2023-10-30 |
CN114945658A (zh) | 2022-08-26 |
WO2021081188A1 (en) | 2021-04-29 |
EP4048775A1 (en) | 2022-08-31 |
US11326140B2 (en) | 2022-05-10 |
JP2023502196A (ja) | 2023-01-23 |
US20220235310A1 (en) | 2022-07-28 |
AU2020370270A1 (en) | 2022-03-24 |
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