MX2022001186A - Compuestos analogos de nitenina y su uso en el tratamiento de dolor cronico y agudo. - Google Patents
Compuestos analogos de nitenina y su uso en el tratamiento de dolor cronico y agudo.Info
- Publication number
- MX2022001186A MX2022001186A MX2022001186A MX2022001186A MX2022001186A MX 2022001186 A MX2022001186 A MX 2022001186A MX 2022001186 A MX2022001186 A MX 2022001186A MX 2022001186 A MX2022001186 A MX 2022001186A MX 2022001186 A MX2022001186 A MX 2022001186A
- Authority
- MX
- Mexico
- Prior art keywords
- nitenin
- treatment
- sup
- sub
- compounds
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/28—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/36—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente descripción se refiere a compuestos análogos de nitenina (de fórmulas I, II, III y IV) y su uso como agente farmacéutico en el tratamiento, prevención o reducción de dolor tanto agudo como crónico. El modo de acción descrito en la presente permite que los compuestos de nitenina y de análogos de nitenina actúen como analgésicos a través de la reducción de corrientes K+ en lugar de su potenciación. Con relación a su alta eficacia en el tratamiento del dolor, estos compuestos son sumamente selectivos para corrientes de potasio activadas por voltaje lentas (K+) expresadas en neuronas de la raíz dorsal de diámetro pequeño (sDRGn), principalmente en las mediadas por el canal de potasio dependiente de voltaje (Kv), Kv1.3. Tales hallazgos, junto con aquellos que demuestran que los compuestos de nitenina y de análogos de nitenina actúan como bloqueadores dependientes de la actividad también conducen a efectos secundarios muy reducidos. Los resultados descritos en la presente muestran que los compuestos de nitenina y de análogos de nitenina descritos en la presente son una alternativa viable para los compuestos farmacéuticos que ya existen que se usan en el tratamiento del dolor.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PT11568519 | 2019-07-31 | ||
PCT/IB2020/056915 WO2021019373A1 (en) | 2019-07-31 | 2020-07-22 | Nitenin analogue compounds and their use in the treatment of chronic and acute pain |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022001186A true MX2022001186A (es) | 2022-05-11 |
Family
ID=72240450
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022001186A MX2022001186A (es) | 2019-07-31 | 2020-07-22 | Compuestos analogos de nitenina y su uso en el tratamiento de dolor cronico y agudo. |
Country Status (10)
Country | Link |
---|---|
US (1) | US20220288017A1 (es) |
EP (1) | EP4003984A1 (es) |
JP (1) | JP2022544057A (es) |
CN (1) | CN114616230A (es) |
AU (1) | AU2020320115A1 (es) |
CA (1) | CA3149175A1 (es) |
IL (1) | IL290192A (es) |
MX (1) | MX2022001186A (es) |
WO (1) | WO2021019373A1 (es) |
ZA (1) | ZA202201154B (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN116115739B (zh) * | 2022-12-29 | 2024-01-09 | 天津市肿瘤医院(天津医科大学肿瘤医院) | 胃动素及其受体激动剂的应用 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0305149D0 (en) * | 2003-03-07 | 2003-04-09 | Cambridge Biotechnology Ltd | Compounds for the treatment of pain |
EP3126831A1 (en) * | 2014-04-01 | 2017-02-08 | The Procter & Gamble Company | Method for screening trp channels |
CN106146530A (zh) * | 2015-04-14 | 2016-11-23 | 中国科学院生态环境研究中心 | 一种合成cephalosporolides E,F,H,I的新方法 |
-
2020
- 2020-07-22 CA CA3149175A patent/CA3149175A1/en active Pending
- 2020-07-22 EP EP20761628.5A patent/EP4003984A1/en active Pending
- 2020-07-22 MX MX2022001186A patent/MX2022001186A/es unknown
- 2020-07-22 AU AU2020320115A patent/AU2020320115A1/en active Pending
- 2020-07-22 CN CN202080057704.6A patent/CN114616230A/zh active Pending
- 2020-07-22 WO PCT/IB2020/056915 patent/WO2021019373A1/en active Application Filing
- 2020-07-22 JP JP2022506029A patent/JP2022544057A/ja active Pending
- 2020-07-22 US US17/631,135 patent/US20220288017A1/en not_active Abandoned
-
2022
- 2022-01-25 ZA ZA2022/01154A patent/ZA202201154B/en unknown
- 2022-01-27 IL IL290192A patent/IL290192A/en unknown
Also Published As
Publication number | Publication date |
---|---|
CA3149175A1 (en) | 2021-02-04 |
ZA202201154B (en) | 2024-02-28 |
WO2021019373A4 (en) | 2021-03-25 |
JP2022544057A (ja) | 2022-10-17 |
CN114616230A (zh) | 2022-06-10 |
AU2020320115A1 (en) | 2022-02-24 |
EP4003984A1 (en) | 2022-06-01 |
WO2021019373A1 (en) | 2021-02-04 |
IL290192A (en) | 2022-03-01 |
US20220288017A1 (en) | 2022-09-15 |
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