MX2021015095A - Construcciones de proteínas de unión a antígenos y usos de estos. - Google Patents
Construcciones de proteínas de unión a antígenos y usos de estos.Info
- Publication number
- MX2021015095A MX2021015095A MX2021015095A MX2021015095A MX2021015095A MX 2021015095 A MX2021015095 A MX 2021015095A MX 2021015095 A MX2021015095 A MX 2021015095A MX 2021015095 A MX2021015095 A MX 2021015095A MX 2021015095 A MX2021015095 A MX 2021015095A
- Authority
- MX
- Mexico
- Prior art keywords
- antigen
- binding protein
- protein constructs
- binding
- dll3
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1018—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6843—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
En el presente documento se proporcionan construcciones de proteínas de unión a antígenos capaces de unirse específicamente a DLL3 o un epítopo de DLL3 presente en la superficie de una célula de mamífero diana, en el que dicha unión a antígeno depende del pH. También se proporcionan usos de dicha construcciones de proteínas de unión a antígenos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962858932P | 2019-06-07 | 2019-06-07 | |
US201962888384P | 2019-08-16 | 2019-08-16 | |
PCT/US2020/036495 WO2020247873A1 (en) | 2019-06-07 | 2020-06-05 | Antigen-binding protein constructs and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021015095A true MX2021015095A (es) | 2022-03-22 |
Family
ID=71899864
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021015095A MX2021015095A (es) | 2019-06-07 | 2020-06-05 | Construcciones de proteínas de unión a antígenos y usos de estos. |
Country Status (9)
Country | Link |
---|---|
US (1) | US20220313845A1 (es) |
EP (1) | EP3980129A1 (es) |
JP (1) | JP2022535452A (es) |
CN (1) | CN114746115A (es) |
AU (1) | AU2020289477A1 (es) |
CA (1) | CA3142884A1 (es) |
IL (1) | IL288685A (es) |
MX (1) | MX2021015095A (es) |
WO (1) | WO2020247873A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20230107901A1 (en) * | 2021-10-01 | 2023-04-06 | University Of Utah Research Foundation | Pathologic tdp-43 as a biomarker for the diagnosis of tdp-43 proteinopathy |
WO2024012524A1 (zh) * | 2022-07-14 | 2024-01-18 | 苏州宜联生物医药有限公司 | 抗体药物偶联物及其制备方法和用途 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
RU2011104348A (ru) | 2008-07-08 | 2012-08-20 | Эбботт Лэборетриз (Us) | Иммуноглобулины с двойным вариабельным доменом против простагландина е2 и их применение |
KR20120060877A (ko) | 2009-09-01 | 2012-06-12 | 아보트 러보러터리즈 | 이원 가변 도메인 면역글로불린 및 이의 용도 |
AU2010306677B2 (en) | 2009-10-15 | 2013-05-23 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
UY32979A (es) | 2009-10-28 | 2011-02-28 | Abbott Lab | Inmunoglobulinas con dominio variable dual y usos de las mismas |
WO2011111007A2 (en) * | 2010-03-11 | 2011-09-15 | Rinat Neuroscience Corporation | ANTIBODIES WITH pH DEPENDENT ANTIGEN BINDING |
TWI667257B (zh) * | 2010-03-30 | 2019-08-01 | 中外製藥股份有限公司 | 促進抗原消失之具有經修飾的FcRn親和力之抗體 |
KR20130100118A (ko) | 2010-08-03 | 2013-09-09 | 아비에 인코포레이티드 | 이원 가변 도메인 면역글로불린 및 이의 용도 |
CN108136015A (zh) * | 2015-08-20 | 2018-06-08 | 艾伯维施特姆森特克斯有限责任公司 | 抗dll3抗体药物缀合物以及使用方法 |
-
2020
- 2020-06-05 EP EP20750441.6A patent/EP3980129A1/en active Pending
- 2020-06-05 AU AU2020289477A patent/AU2020289477A1/en active Pending
- 2020-06-05 CA CA3142884A patent/CA3142884A1/en active Pending
- 2020-06-05 JP JP2021572559A patent/JP2022535452A/ja active Pending
- 2020-06-05 US US17/616,804 patent/US20220313845A1/en active Pending
- 2020-06-05 MX MX2021015095A patent/MX2021015095A/es unknown
- 2020-06-05 CN CN202080055954.6A patent/CN114746115A/zh active Pending
- 2020-06-05 WO PCT/US2020/036495 patent/WO2020247873A1/en unknown
-
2021
- 2021-12-05 IL IL288685A patent/IL288685A/en unknown
Also Published As
Publication number | Publication date |
---|---|
CN114746115A (zh) | 2022-07-12 |
JP2022535452A (ja) | 2022-08-08 |
WO2020247873A1 (en) | 2020-12-10 |
AU2020289477A1 (en) | 2022-02-03 |
US20220313845A1 (en) | 2022-10-06 |
IL288685A (en) | 2022-02-01 |
EP3980129A1 (en) | 2022-04-13 |
CA3142884A1 (en) | 2020-12-10 |
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