MX2021014111A - Proceso para la preparacion de epimeros de fosforamidita de galnac. - Google Patents

Proceso para la preparacion de epimeros de fosforamidita de galnac.

Info

Publication number
MX2021014111A
MX2021014111A MX2021014111A MX2021014111A MX2021014111A MX 2021014111 A MX2021014111 A MX 2021014111A MX 2021014111 A MX2021014111 A MX 2021014111A MX 2021014111 A MX2021014111 A MX 2021014111A MX 2021014111 A MX2021014111 A MX 2021014111A
Authority
MX
Mexico
Prior art keywords
preparation
epimers
galnac
galnac phosphoramidite
phosphoramidite
Prior art date
Application number
MX2021014111A
Other languages
English (en)
Inventor
Kurt Puentener
Simon Adolf Breitler
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2021014111A publication Critical patent/MX2021014111A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/08—Polyoxyalkylene derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La invención comprende un proceso para la preparación de un epímero de fosforamidita de GalNAc de fórmula I, en donde R1 es un grupo protector de hidroxilo, n es un número entero de 0 a 10 y m es un número entero de 0 a 20, enantiómeros y/o isómeros ópticos correspondientes del mismo y el uso del proceso para la preparación de conjugados de oligonucleótidos de complejo GalNAc.
MX2021014111A 2019-05-20 2020-05-18 Proceso para la preparacion de epimeros de fosforamidita de galnac. MX2021014111A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP19175309 2019-05-20
PCT/EP2020/063749 WO2020234208A1 (en) 2019-05-20 2020-05-18 Process for the preparation of galnac phosphoramidite epimers

Publications (1)

Publication Number Publication Date
MX2021014111A true MX2021014111A (es) 2021-12-10

Family

ID=66625050

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021014111A MX2021014111A (es) 2019-05-20 2020-05-18 Proceso para la preparacion de epimeros de fosforamidita de galnac.

Country Status (13)

Country Link
US (1) US20220259248A1 (es)
EP (1) EP3972984A1 (es)
JP (1) JP2022533220A (es)
KR (1) KR20220010496A (es)
CN (1) CN113840828B (es)
AR (1) AR118949A1 (es)
AU (1) AU2020278797A1 (es)
CA (1) CA3134494A1 (es)
IL (1) IL288116A (es)
MX (1) MX2021014111A (es)
SG (1) SG11202110680PA (es)
TW (1) TW202110483A (es)
WO (1) WO2020234208A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023143571A1 (zh) * 2022-01-30 2023-08-03 大睿生物医药科技(上海)有限公司 含有n-乙酰半乳糖胺的靶向配体
WO2024075760A1 (ja) * 2022-10-05 2024-04-11 第一三共株式会社 ２分岐型ｎ－アセチル－ｄ－ガラクトサミン構造を有する化合物の製造方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX369556B (es) * 2015-08-06 2019-11-12 Hoffmann La Roche Procesos para la preparacion de derivados acidos de n-acetilgalactosamina (galnac).
AR106683A1 (es) * 2015-11-16 2018-02-07 Hoffmann La Roche FOSFORAMIDITA DE AGRUPACIÓN DE GalNAc
WO2018215049A1 (en) 2017-05-23 2018-11-29 F. Hoffmann-La Roche Ag Process for galnac oligonucleotide conjugates

Also Published As

Publication number Publication date
IL288116A (en) 2022-01-01
KR20220010496A (ko) 2022-01-25
CN113840828B (zh) 2024-01-16
US20220259248A1 (en) 2022-08-18
JP2022533220A (ja) 2022-07-21
CA3134494A1 (en) 2020-11-26
EP3972984A1 (en) 2022-03-30
TW202110483A (zh) 2021-03-16
CN113840828A (zh) 2021-12-24
AR118949A1 (es) 2021-11-10
SG11202110680PA (en) 2021-10-28
WO2020234208A1 (en) 2020-11-26
AU2020278797A1 (en) 2021-10-07

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