MX2021013218A - Composiciones y metodos para el tratamiento del cancer usando una terapia con celulas t modificadas con tet2. - Google Patents

Composiciones y metodos para el tratamiento del cancer usando una terapia con celulas t modificadas con tet2.

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Publication number
MX2021013218A
MX2021013218A MX2021013218A MX2021013218A MX2021013218A MX 2021013218 A MX2021013218 A MX 2021013218A MX 2021013218 A MX2021013218 A MX 2021013218A MX 2021013218 A MX2021013218 A MX 2021013218A MX 2021013218 A MX2021013218 A MX 2021013218A
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MX
Mexico
Prior art keywords
cancer
compositions
treatment
methods
tet2
Prior art date
Application number
MX2021013218A
Other languages
English (en)
Inventor
Alex Franzusoff
Barbara Sennino
Stefanie Mandl-Cashman
Kyle Jacoby
Michael M Dubreuil
John Gagnon
Original Assignee
Pact Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pact Pharma Inc filed Critical Pact Pharma Inc
Publication of MX2021013218A publication Critical patent/MX2021013218A/es

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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2501/20—Cytokines; Chemokines
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    • C12N2510/00—Genetically modified cells
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Abstract

Composiciones y métodos para el tratamiento del cáncer usando una terapia celular basada en neoTCR con una inactivación de la expresión del gen TET2.
MX2021013218A 2019-05-01 2020-04-30 Composiciones y metodos para el tratamiento del cancer usando una terapia con celulas t modificadas con tet2. MX2021013218A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962841753P 2019-05-01 2019-05-01
US201962841748P 2019-05-01 2019-05-01
PCT/US2020/030704 WO2020223478A1 (en) 2019-05-01 2020-04-30 Compositions and methods for the treatment of cancer using a tet2 engineered t cell therapy

Publications (1)

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MX2021013218A true MX2021013218A (es) 2021-12-10

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MX2021013218A MX2021013218A (es) 2019-05-01 2020-04-30 Composiciones y metodos para el tratamiento del cancer usando una terapia con celulas t modificadas con tet2.
MX2021013225A MX2021013225A (es) 2019-05-01 2020-04-30 Composiciones y metodos para el tratamiento del cancer utilizando una terapia de celulas t modificadas de cd8.

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MX2021013225A MX2021013225A (es) 2019-05-01 2020-04-30 Composiciones y metodos para el tratamiento del cancer utilizando una terapia de celulas t modificadas de cd8.

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US (3) US20210085720A1 (es)
EP (2) EP3953379A4 (es)
JP (2) JP2022530653A (es)
KR (2) KR20220004703A (es)
CN (1) CN113748127A (es)
AU (2) AU2020266579A1 (es)
CA (2) CA3136740A1 (es)
IL (2) IL287639A (es)
MX (2) MX2021013218A (es)
SG (2) SG11202111865UA (es)
WO (3) WO2020223478A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2019347873A1 (en) * 2018-09-28 2021-05-13 Memorial Sloan-Kettering Cancer Center Immunoresponsive cells expressing dominant negative Fas and uses thereof
BR112022003891A2 (pt) * 2019-09-06 2022-05-31 Crispr Therapeutics Ag Células t geneticamente manipuladas possuindo persistência melhorada em cultura
WO2022109277A1 (en) * 2020-11-20 2022-05-27 Pact Pharma, Inc. COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER USING A TGFβRII ENGINEERED T CELL THERAPY
CA3201767A1 (en) * 2020-12-14 2022-06-23 Thomas M. Schmitt Compositions and methods for cellular immunotherapy
WO2022140361A1 (en) * 2020-12-22 2022-06-30 Ludwig Institute For Cancer Research Ltd Genetically engineered lymphocytes for adoptive cell therapy
WO2022177970A1 (en) * 2021-02-18 2022-08-25 University Of Florida Research Foundation, Incorporated Enhancing metabolic fitness of t cells to treat cancer
CA3172530A1 (en) 2021-02-25 2022-09-01 Spencer PARK Ror1 targeting chimeric antigen receptor
AU2022226655A1 (en) 2021-02-25 2023-07-27 Lyell Immunopharma, Inc. Codon-optimized nucleotide sequences encoding an ap-1 transcription factor
CA3222120A1 (en) * 2021-06-11 2022-12-15 Bhamini PURANDARE Methods of assessing cell products
US20230310605A1 (en) 2021-10-28 2023-10-05 Lyell Immunopharma, Inc. Methods for culturing cells expressing ror1-binding protein
WO2023077032A1 (en) 2021-10-28 2023-05-04 Lyell Immunopharma, Inc. Methods for culturing cells expressing c-jun
CN114373511B (zh) * 2022-03-15 2022-08-30 南方医科大学南方医院 基于5hmC分子标志物检测的肠癌模型及肠癌模型构建方法
WO2023212507A1 (en) * 2022-04-26 2023-11-02 Fred Hutchinson Cancer Center Compositions and methods for cellular immunotherapy
WO2024026490A1 (en) 2022-07-28 2024-02-01 Sqz Biotechnologies Company Polynucleotides encoding linked antigens and uses thereof
WO2024064958A1 (en) 2022-09-23 2024-03-28 Lyell Immunopharma, Inc. Methods for culturing nr4a-deficient cells
WO2024064952A1 (en) 2022-09-23 2024-03-28 Lyell Immunopharma, Inc. Methods for culturing nr4a-deficient cells overexpressing c-jun
WO2024077174A1 (en) 2022-10-05 2024-04-11 Lyell Immunopharma, Inc. Methods for culturing nr4a-deficient cells

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5399346A (en) 1989-06-14 1995-03-21 The United States Of America As Represented By The Department Of Health And Human Services Gene therapy
US20020127594A1 (en) * 2000-06-22 2002-09-12 Gearing David P. Don-1 gene and polypeptides and uses therefor
US6355412B1 (en) * 1999-07-09 2002-03-12 The European Molecular Biology Laboratory Methods and compositions for directed cloning and subcloning using homologous recombination
US7485291B2 (en) * 2003-06-03 2009-02-03 Cell Genesys, Inc. Compositions and methods for generating multiple polypeptides from a single vector using a virus derived peptide cleavage site, and uses thereof
WO2008042814A2 (en) * 2006-09-29 2008-04-10 California Institute Of Technology Mart-1 t cell receptors
US9833476B2 (en) * 2011-08-31 2017-12-05 The Trustees Of Dartmouth College NKP30 receptor targeted therapeutics
WO2014039044A1 (en) * 2012-09-06 2014-03-13 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of producing t memory stem cell populations
EP3858378A1 (en) * 2013-11-21 2021-08-04 Autolus Limited Cell
CN108633287A (zh) * 2015-09-17 2018-10-09 诺华股份有限公司 功效增强的car t细胞治疗
CN108699132B (zh) * 2015-12-18 2023-08-11 桑格摩生物治疗股份有限公司 Mhc细胞受体的靶向破坏
US20170319722A1 (en) * 2016-04-04 2017-11-09 Indi Molecular, Inc. Cd8-specific capture agents, compositions, and methods of using and making
EA201990591A1 (ru) * 2016-09-23 2019-08-30 Фред Хатчинсон Кэнсер Рисерч Сентер Tcr, специфичные к минорному антигену гистосовместимости (h) ha-1, и их применения
US11058752B2 (en) * 2016-11-22 2021-07-13 Alloplex Biotherapeutics Allogeneic tumor cell vaccine
BR112019018863A8 (pt) * 2017-03-15 2023-05-02 Hutchinson Fred Cancer Res Tcrs de alta afinidade específicos para mage-a1 e usos dos mesmos
CA3054621A1 (en) * 2017-03-22 2018-09-27 Novartis Ag Compositions and methods for immunooncology
US11512287B2 (en) * 2017-06-16 2022-11-29 Sangamo Therapeutics, Inc. Targeted disruption of T cell and/or HLA receptors
WO2019004831A1 (en) * 2017-06-30 2019-01-03 Academisch Ziekenhuis Leiden (H.O.D.N. Leids Universitair Medisch Centrum) TREATMENT OF HEMATOLOGICAL MALIGNANCIES
CA3072777A1 (en) * 2017-09-08 2019-03-14 Poseida Therapeutics, Inc. Compositions and methods for chimeric ligand receptor (clr)-mediated conditional gene expression
BR112020008704A2 (pt) * 2017-10-30 2020-11-10 Pact Pharma, Inc. edição de genes de células primárias
US20200338128A1 (en) * 2018-01-05 2020-10-29 Gencyte Therapeutics, Inc. Precision molecular adaptor system for car-t immunotherapy
JP2021520212A (ja) 2018-04-02 2021-08-19 パクト ファーマ インコーポレイテッドＰａｃｔ Ｐｈａｒｍａ， Ｉｎｃ． ペプチド−ｍｈｃ ｃｏｍｐａｃｔ
EP3847266A1 (en) * 2018-09-05 2021-07-14 GlaxoSmithKline Intellectual Property Development Ltd T cell modification
GB201819540D0 (en) * 2018-11-30 2019-01-16 Adaptimmune Ltd T cell modification
KR20210126073A (ko) 2019-02-12 2021-10-19 팩트 파마, 인크. 항원 특이적 t 세포의 식별을 위한 조성물 및 방법
PE20220164A1 (es) * 2019-05-27 2022-01-28 Immatics Us Inc Vectores viricos y uso de los mismos en terapias celulares adoptivas

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US20210085721A1 (en) 2021-03-25
US20220193139A1 (en) 2022-06-23
KR20220004703A (ko) 2022-01-11
US11304978B2 (en) 2022-04-19
JP2022530653A (ja) 2022-06-30
MX2021013225A (es) 2022-01-06
EP3962938A4 (en) 2023-07-05
US20210085720A1 (en) 2021-03-25
WO2020223537A8 (en) 2021-11-11
WO2020223478A1 (en) 2020-11-05
AU2020264484A1 (en) 2021-11-04
EP3953379A1 (en) 2022-02-16
IL287643A (en) 2021-12-01
JP2022531231A (ja) 2022-07-06
CN113748127A (zh) 2021-12-03
WO2020223537A1 (en) 2020-11-05
IL287639A (en) 2021-12-01
EP3953379A4 (en) 2023-05-31
WO2020223625A1 (en) 2020-11-05
EP3962938A1 (en) 2022-03-09
CA3151385A1 (en) 2020-11-05
SG11202111532SA (en) 2021-11-29
CA3136740A1 (en) 2020-11-05
SG11202111865UA (en) 2021-11-29
KR20220005050A (ko) 2022-01-12
AU2020266579A1 (en) 2021-11-25

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