MX2021009426A - Derivados de indazolil-isoxazol para el tratamiento de enfermedades tales como cancer. - Google Patents

Derivados de indazolil-isoxazol para el tratamiento de enfermedades tales como cancer.

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Publication number
MX2021009426A
MX2021009426A MX2021009426A MX2021009426A MX2021009426A MX 2021009426 A MX2021009426 A MX 2021009426A MX 2021009426 A MX2021009426 A MX 2021009426A MX 2021009426 A MX2021009426 A MX 2021009426A MX 2021009426 A MX2021009426 A MX 2021009426A
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MX
Mexico
Prior art keywords
cancer
treatment
indazolyl
diseases
isoxazole derivatives
Prior art date
Application number
MX2021009426A
Other languages
English (en)
Inventor
Dieter Dorsch
Andreas Blum
Original Assignee
Merck Patent Gmbh
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Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of MX2021009426A publication Critical patent/MX2021009426A/es

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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07C311/48—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom
    • C07C311/49—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom to nitrogen atoms
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    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
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    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring

Abstract

Los compuestos de la fórmula I (ver Fórmula) en la cual R1, R2, X, Y y Z tienen los significados indicados en la reivindicación 1, son inhibidores de c-Kit cinasa, y se pueden emplear para el tratamiento de un cáncer.
MX2021009426A 2019-02-11 2020-02-10 Derivados de indazolil-isoxazol para el tratamiento de enfermedades tales como cancer. MX2021009426A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP19156318 2019-02-11
PCT/EP2020/053241 WO2020165062A1 (en) 2019-02-11 2020-02-10 Indazolyl-isoxazole derivatives for the treatment of diseases such as cancer

Publications (1)

Publication Number Publication Date
MX2021009426A true MX2021009426A (es) 2021-09-10

Family

ID=65408901

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021009426A MX2021009426A (es) 2019-02-11 2020-02-10 Derivados de indazolil-isoxazol para el tratamiento de enfermedades tales como cancer.

Country Status (13)

Country Link
US (1) US20220127254A1 (es)
EP (1) EP3924340A1 (es)
JP (1) JP2022520374A (es)
KR (1) KR20210129674A (es)
CN (1) CN113474334A (es)
AR (1) AR118043A1 (es)
AU (1) AU2020220333A1 (es)
BR (1) BR112021014466A2 (es)
CA (1) CA3129601A1 (es)
IL (1) IL285421A (es)
MX (1) MX2021009426A (es)
SG (1) SG11202108636SA (es)
WO (1) WO2020165062A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2020007956A (es) 2018-01-29 2021-01-08 Capulus Therapeutics Llc Inhibidores de la proteína de unión al elemento regulador de esterol (srebp) que comprenden un anillo central de 6 miembros.
CA3157442A1 (en) * 2019-11-13 2021-05-20 Capulus Therapeutics, Llc Srebp inhibitor comprising a thiophene central ring
CN114000167B (zh) * 2021-11-25 2024-02-06 南京先进生物材料与过程装备研究院有限公司 一种电化学合成吡唑类化合物的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS52010B (en) * 2005-06-22 2012-04-30 Plexxikon Inc. DERIVATI PIROLO [2, 3-B] PIRIDINA KAO INHIBITORI PROTEIN KINAZE
AU2011347711B2 (en) * 2010-12-20 2017-02-02 Merck Serono S.A. Indazolyl triazole derivatives as IRAK inhibitors
ES2898882T3 (es) * 2016-01-11 2022-03-09 Merck Patent Gmbh Derivados de quinolin-2-ona
WO2019051199A1 (en) * 2017-09-08 2019-03-14 Incyte Corporation 6-CYANO-INDAZOLE COMPOUNDS AS HEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) MODULATORS

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AR118043A1 (es) 2021-09-15
BR112021014466A2 (pt) 2021-09-21
KR20210129674A (ko) 2021-10-28
JP2022520374A (ja) 2022-03-30
EP3924340A1 (en) 2021-12-22
IL285421A (en) 2021-09-30
AU2020220333A1 (en) 2021-09-30
US20220127254A1 (en) 2022-04-28
CN113474334A (zh) 2021-10-01
SG11202108636SA (en) 2021-09-29
CA3129601A1 (en) 2020-08-20
WO2020165062A1 (en) 2020-08-20

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