MX2021008874A - Adn de extremo cerrado (ceadn) y uso en metodos de reduccion de la respuesta inmunitaria relacionada con tratamiento genico o de acido nucleico. - Google Patents

Adn de extremo cerrado (ceadn) y uso en metodos de reduccion de la respuesta inmunitaria relacionada con tratamiento genico o de acido nucleico.

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Publication number
MX2021008874A
MX2021008874A MX2021008874A MX2021008874A MX2021008874A MX 2021008874 A MX2021008874 A MX 2021008874A MX 2021008874 A MX2021008874 A MX 2021008874A MX 2021008874 A MX2021008874 A MX 2021008874A MX 2021008874 A MX2021008874 A MX 2021008874A
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Mexico
Prior art keywords
immune response
methods
cedna
nucleic acid
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MX2021008874A
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English (en)
Inventor
Phillip Samayoa
Robert M Kotin
Ozan Alkan
Douglas Anthony Kerr
Matthew G Stanton
Matthew Chiocco
Raj Rajendran
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Generation Bio Co
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Publication date
Application filed by Generation Bio Co filed Critical Generation Bio Co
Publication of MX2021008874A publication Critical patent/MX2021008874A/es

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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N15/86—Viral vectors
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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  • Health & Medical Sciences (AREA)
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  • Genetics & Genomics (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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Abstract

En la presente se proporcionan métodos y construcciones relacionados con la minimización de respuestas inmunitarias mediante inhibidores de la respuesta inmunitaria, en particular la respuesta inmunitaria innata, cuando se administra un transgén deseado en una célula lograda mediante la administración del transgén con dosis repetidas de un vector de ceADN.
MX2021008874A 2019-01-24 2020-01-24 Adn de extremo cerrado (ceadn) y uso en metodos de reduccion de la respuesta inmunitaria relacionada con tratamiento genico o de acido nucleico. MX2021008874A (es)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201962796417P 2019-01-24 2019-01-24
US201962796450P 2019-01-24 2019-01-24
US201962800285P 2019-02-01 2019-02-01
US201962800303P 2019-02-01 2019-02-01
US201962814424P 2019-03-06 2019-03-06
US201962814414P 2019-03-06 2019-03-06
US201962857542P 2019-06-05 2019-06-05
PCT/US2020/015026 WO2020154645A1 (en) 2019-01-24 2020-01-24 Close-ended dna (cedna) and use in methods of reducing gene or nucleic acid therapy related immune response

Publications (1)

Publication Number Publication Date
MX2021008874A true MX2021008874A (es) 2021-08-19

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MX2021008874A MX2021008874A (es) 2019-01-24 2020-01-24 Adn de extremo cerrado (ceadn) y uso en metodos de reduccion de la respuesta inmunitaria relacionada con tratamiento genico o de acido nucleico.

Country Status (11)

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US (1) US20220119840A1 (es)
EP (1) EP3914717A4 (es)
JP (1) JP2022518504A (es)
KR (1) KR20210119416A (es)
CN (1) CN113412331A (es)
AU (1) AU2020211457A1 (es)
CA (1) CA3127799A1 (es)
MA (1) MA54826A (es)
MX (1) MX2021008874A (es)
SG (1) SG11202107922QA (es)
WO (1) WO2020154645A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2020005790A (es) * 2018-01-19 2020-10-28 Generation Bio Co Vectores de adn de extremo cerrado que pueden obtenerse de síntesis libre de células y un proceso para obtener vectores de ceadn.
CN108920903B (zh) * 2018-07-09 2022-04-01 湘潭大学 基于朴素贝叶斯的LncRNA与疾病的关联关系预测方法及***
US20210371465A1 (en) * 2020-03-26 2021-12-02 Yale University Method of using a tlr9 antagonist as an anti-inflammatory and anti-fibrotic agent
EP4189098A1 (en) 2020-07-27 2023-06-07 Anjarium Biosciences AG Compositions of dna molecules, methods of making therefor, and methods of use thereof
CN112138164B (zh) * 2020-09-25 2022-06-03 徐州医科大学 Aim2在制备降低car-t治疗毒副作用的药物中的应用
AU2022227607A1 (en) 2021-02-23 2023-08-24 Poseida Therapeutics, Inc. Compositions and methods for delivery of nucleic acids
CN114796216A (zh) * 2022-01-04 2022-07-29 南京医科大学 甲氟喹在防治全身代谢性炎症疾病中的应用
WO2024059904A1 (en) * 2022-09-20 2024-03-28 The Council Of The Queensland Institute Of Medical Research Anti-fibrotic microrna composition
WO2024121814A1 (en) * 2022-12-09 2024-06-13 Takeda Pharmaceutical Company Limited Modified immunomodulators

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2843636A1 (en) * 2011-07-29 2013-02-07 Fred Hutchinson Cancer Research Center Methods and compositions for modulating the innate immune response and/or myogenesis in a mammalian subject
ES2898337T3 (es) * 2016-03-03 2022-03-07 Univ Massachusetts ADN dúplex lineal de extremos cerrados para la transferencia de genes no víricos
US11339396B2 (en) * 2016-06-08 2022-05-24 President And Fellows Of Harvard College Engineered viral vector reduces induction of inflammatory and immune responses

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EP3914717A1 (en) 2021-12-01
JP2022518504A (ja) 2022-03-15
SG11202107922QA (en) 2021-08-30
CA3127799A1 (en) 2020-07-30
AU2020211457A1 (en) 2021-09-09
US20220119840A1 (en) 2022-04-21
CN113412331A (zh) 2021-09-17
WO2020154645A1 (en) 2020-07-30
MA54826A (fr) 2021-12-01
EP3914717A4 (en) 2022-11-16
KR20210119416A (ko) 2021-10-05

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