MX2020011546A - Anticuerpos anti-msr1 y metodos de uso de los mismos. - Google Patents

Anticuerpos anti-msr1 y metodos de uso de los mismos.

Info

Publication number
MX2020011546A
MX2020011546A MX2020011546A MX2020011546A MX2020011546A MX 2020011546 A MX2020011546 A MX 2020011546A MX 2020011546 A MX2020011546 A MX 2020011546A MX 2020011546 A MX2020011546 A MX 2020011546A MX 2020011546 A MX2020011546 A MX 2020011546A
Authority
MX
Mexico
Prior art keywords
antibodies
msr1
methods
bind
antigen
Prior art date
Application number
MX2020011546A
Other languages
English (en)
Inventor
Viktoria Gusarova
Thomas Nittoli
Christos Kyratsous
Andrew J Murphy
Matthew Sleeman
Amy Han
William Olson
Jesper Gromada
Anna Zumsteg
Sokol Haxhinasto
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of MX2020011546A publication Critical patent/MX2020011546A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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Abstract

En el presente documento se proporcionan anticuerpos y fragmentos de unión a antígeno que se unen a MSR1 y métodos de uso de los mismos. De acuerdo con ciertas modalidades, los anticuerpos se unen a MSR1 humano con alta afinidad. En determinadas modalidades, los anticuerpos se unen a MSR1 sin bloquear, o bloquear menos del 90%, de la unión de LDL modificada a MSR1. En algunas modalidades, los anticuerpos se unen al MSR1 expresado en la superficie celular y se internalizan. Los anticuerpos de la invención pueden ser anticuerpos completamente humanos. La invención incluye anticuerpos anti-MSR1, o fragmentos de unión a antígeno de los mismos, conjugados con fármacos o compuestos terapéuticos.
MX2020011546A 2018-05-09 2019-05-08 Anticuerpos anti-msr1 y metodos de uso de los mismos. MX2020011546A (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201862669276P 2018-05-09 2018-05-09
US201862678200P 2018-05-30 2018-05-30
US201862769946P 2018-11-20 2018-11-20
US201962789987P 2019-01-08 2019-01-08
US201962821362P 2019-03-20 2019-03-20
PCT/US2019/031383 WO2019217591A1 (en) 2018-05-09 2019-05-08 Anti-msr1 antibodies and methods of use thereof

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MX2020011546A true MX2020011546A (es) 2021-01-29

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US (2) US11377502B2 (es)
EP (1) EP3790899A1 (es)
JP (1) JP2021523147A (es)
KR (1) KR20210008008A (es)
CN (1) CN112533951A (es)
AU (1) AU2019265703A1 (es)
BR (1) BR112020022400A2 (es)
CA (1) CA3098453A1 (es)
CL (1) CL2020002873A1 (es)
CO (1) CO2020015084A2 (es)
MX (1) MX2020011546A (es)
PH (1) PH12020551865A1 (es)
SG (1) SG11202010909RA (es)
WO (1) WO2019217591A1 (es)

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