MX2020010636A - Proceso para la produccion de acidos 2,6-dialquilfenilaceticos. - Google Patents

Proceso para la produccion de acidos 2,6-dialquilfenilaceticos.

Info

Publication number
MX2020010636A
MX2020010636A MX2020010636A MX2020010636A MX2020010636A MX 2020010636 A MX2020010636 A MX 2020010636A MX 2020010636 A MX2020010636 A MX 2020010636A MX 2020010636 A MX2020010636 A MX 2020010636A MX 2020010636 A MX2020010636 A MX 2020010636A
Authority
MX
Mexico
Prior art keywords
dialkylphenyl
producing
acetic acids
benzyl alcohol
bromobenzenes
Prior art date
Application number
MX2020010636A
Other languages
English (en)
Inventor
Thomas Himmler
Wahed Ahmed Moradi
Dirk Brohm
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of MX2020010636A publication Critical patent/MX2020010636A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/14—Preparation of carboxylic acid nitriles by reaction of cyanides with halogen-containing compounds with replacement of halogen atoms by cyano groups
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J25/00—Catalysts of the Raney type
    • B01J25/02—Raney nickel
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/16—Preparation of halogenated hydrocarbons by replacement by halogens of hydroxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/35—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/14—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of a —CHO group
    • C07C29/141—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of a —CHO group with hydrogen or hydrogen-containing gases
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C07C309/66—Methanesulfonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/46—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/42—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydrolysis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/516—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of nitrogen-containing compounds to >C = O groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/56—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/08—Preparation of carboxylic acids or their salts, halides or anhydrides from nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/15—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
    • C07C53/19—Acids containing three or more carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
    • C07F3/02—Magnesium compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Materials Engineering (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La invención se refiere a un proceso de múltiples pasos para preparar ácidos 2,6- dialquilfenilacéticos de la fórmula general (I) haciendo reaccionar 2,6-dialquilbromobencenos con (1) magnesio, (2) una formamida, (3) un ácido, (4) hidrogenación del benzaldehído obtenido, (5) activación del alcohol bencílico obtenido, (6) cianación del alcohol bencílico activado y (7) hidrólisis del nitrilo obtenido.
MX2020010636A 2018-04-10 2019-04-03 Proceso para la produccion de acidos 2,6-dialquilfenilaceticos. MX2020010636A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18166472 2018-04-10
PCT/EP2019/058356 WO2019197232A1 (de) 2018-04-10 2019-04-03 Verfahren zur herstellung von 2,6-dialkylphenyl-essigsäuren

Publications (1)

Publication Number Publication Date
MX2020010636A true MX2020010636A (es) 2020-10-28

Family

ID=62001953

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020010636A MX2020010636A (es) 2018-04-10 2019-04-03 Proceso para la produccion de acidos 2,6-dialquilfenilaceticos.

Country Status (10)

Country Link
US (1) US11691938B2 (es)
EP (1) EP3774719A1 (es)
JP (1) JP7353295B2 (es)
KR (1) KR20200140351A (es)
CN (1) CN112004795A (es)
BR (1) BR112020019277B1 (es)
IL (1) IL277812B2 (es)
MX (1) MX2020010636A (es)
TW (1) TWI796463B (es)
WO (1) WO2019197232A1 (es)

Family Cites Families (22)

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JPS5867637A (ja) * 1981-10-20 1983-04-22 Nippon Kayaku Co Ltd ヒドロキシベンジルアルコ−ル類の製造法
JP2935453B2 (ja) * 1994-12-07 1999-08-16 科学技術振興事業団 アルコール類の製造方法
SE9801526D0 (sv) 1998-04-29 1998-04-29 Astra Ab New compounds
KR20020047198A (ko) 1999-09-30 2002-06-21 해피 페너 ; 해리 에이치. 페너 2세 특정 알킬렌 디아민-치환된피라졸로[1,5-ａ]-1,5-피리미딘 및피라졸로[1,5-ａ]-1,3,5-트리아진
CA2379633C (en) 1999-09-30 2006-06-20 Neurogen Corporation Amino substituted pyrazolo[1,5,-a]-1,5-pyrimidines and pyrazolo[1,5-a]-1,3,5-triazines
JP2001158754A (ja) 1999-11-30 2001-06-12 Showa Denko Kk テトラフルオロベンゼンジメタノールの製造方法
AR042282A1 (es) 2002-12-05 2005-06-15 Syngenta Participations Ag Proceso para la preparacion de dinitrilos de acido fenilmalonico
ITPD20040115A1 (it) 2004-05-04 2004-08-04 Univ Degli Studi Udine Complessi di rutenio con 2-(amminometil)piridine e fosfine, loro preparazione ed uso come catalizzatori
US20070293532A1 (en) 2004-07-28 2007-12-20 Takeda Pharmaceutical Compan6Y Limited Pyrrolo [2,3-C] Pyridine Compound, Process for Producing the Same, and Use
DE102005008021A1 (de) 2005-02-22 2006-08-24 Bayer Cropscience Ag Spiroketal-substituierte cyclische Ketoenole
JP2007031430A (ja) 2005-06-22 2007-02-08 Showa Denko Kk 核ハロゲン化メチルベンジルアルコールの製造方法
MX337100B (es) * 2007-10-05 2016-02-11 Acucela Inc Compuestos alcoxi para el tratamiento de enfermedades.
US8367873B2 (en) * 2008-10-10 2013-02-05 Bayer Cropscience Ag Phenyl-substituted bicyclooctane-1,3-dione derivatives
JP2010235603A (ja) 2009-03-13 2010-10-21 Sumitomo Chemical Co Ltd ピリダジノン化合物及びその用途
JP6081797B2 (ja) 2009-07-07 2017-02-15 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ （２，４−ジメチルビフェニル−３−イル）酢酸、それらのエステルおよび中間体を調製する方法
EP2526081B1 (de) 2010-01-19 2015-07-01 Bayer Intellectual Property GmbH Verfahren zur herstellung von aryl- und heteroarylessigsäure-derivaten
WO2013025425A1 (en) * 2011-08-12 2013-02-21 Boehringer Ingelheim International Gmbh Soluble guanylate cyclase activators
CN102633626B (zh) * 2012-04-06 2016-03-02 宿迁科思化学有限公司 一种2,4,6-三甲基苯乙酰氯合成工艺
WO2016071920A2 (en) * 2014-11-07 2016-05-12 Excel Industries Ltd. A process for preparation of 3,4-dimethylbenzaldehyde
GB201509663D0 (en) 2015-06-03 2015-07-15 Johnson Matthey Plc Benzo(h)quinoline ligands and complexes thereof
ES2886953T3 (es) 2016-01-15 2021-12-21 Bayer Cropscience Ag Procedimiento para la preparación de 2-(4-cloro-2,6-dimetilfenil)etanol
EP3487837B1 (en) 2016-07-22 2022-08-17 Syngenta Participations AG Process for the preparation of spiroheterocyclic pyrrolidine dione herbicides by means of the intermediate compound 2-(4-chloro-2,6-dimethyl-phenyl)acetic acid

Also Published As

Publication number Publication date
TWI796463B (zh) 2023-03-21
BR112020019277A2 (pt) 2021-01-05
IL277812A (en) 2020-11-30
KR20200140351A (ko) 2020-12-15
JP2021521127A (ja) 2021-08-26
CN112004795A (zh) 2020-11-27
JP7353295B2 (ja) 2023-09-29
IL277812B2 (en) 2023-10-01
US11691938B2 (en) 2023-07-04
WO2019197232A1 (de) 2019-10-17
US20210403406A1 (en) 2021-12-30
IL277812B1 (en) 2023-06-01
TW201945324A (zh) 2019-12-01
EP3774719A1 (de) 2021-02-17
BR112020019277B1 (pt) 2024-01-16

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