MX2020009711A - Combinacion de quinolin-4-carboxamidas y derivados de benzonaftiridina como combinacion de farmacos antipaludicos. - Google Patents

Combinacion de quinolin-4-carboxamidas y derivados de benzonaftiridina como combinacion de farmacos antipaludicos.

Info

Publication number
MX2020009711A
MX2020009711A MX2020009711A MX2020009711A MX2020009711A MX 2020009711 A MX2020009711 A MX 2020009711A MX 2020009711 A MX2020009711 A MX 2020009711A MX 2020009711 A MX2020009711 A MX 2020009711A MX 2020009711 A MX2020009711 A MX 2020009711A
Authority
MX
Mexico
Prior art keywords
combination
quinoline
carboxamides
prodrug
pharmaceutically acceptable
Prior art date
Application number
MX2020009711A
Other languages
English (en)
Inventor
Thomas Spangenberg
Claude Oeuvray
Nada Abla
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of MX2020009711A publication Critical patent/MX2020009711A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

La presente invención se relaciona con una combinación que comprende, como primer ingrediente activo, (2-pirrolidin-1-il-etil )-amida del ácido 6-fluoro-2-(4-morfolin-4-ilmetil-fenil)-quinolin -4-carboxílico o un profármaco o una sal farmacéuticamente aceptable del mismo y como segundo ingrediente activo pironaridina o un profármaco o sal farmacéuticamente aceptable de la misma. La presente invención también se relaciona con una combinación de tres ingredientes activos antipalúdicos, es decir, (2-pirrolidin-1-il-etil)-amida del ácido 6-fluoro-2-(4-morfolin-4- ilmetil-fenil)-quinolin-4-carboxílico o un profármaco o sal del mismo, pironaridina o una sal farmacéuticamente aceptable de la misma, y artemisinina o sus derivados. La invención además se relaciona con composiciones farmacéuticas que comprenden tal combinación y su uso en el tratamiento y/o prevención de la malaria.
MX2020009711A 2018-04-11 2019-04-09 Combinacion de quinolin-4-carboxamidas y derivados de benzonaftiridina como combinacion de farmacos antipaludicos. MX2020009711A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18166769 2018-04-11
PCT/EP2019/058881 WO2019197367A1 (en) 2018-04-11 2019-04-09 Combination of quinoline-4-carboxamides and benzonaphthyridine derivatives as antimalarial drug combination

Publications (1)

Publication Number Publication Date
MX2020009711A true MX2020009711A (es) 2020-10-07

Family

ID=61971934

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020009711A MX2020009711A (es) 2018-04-11 2019-04-09 Combinacion de quinolin-4-carboxamidas y derivados de benzonaftiridina como combinacion de farmacos antipaludicos.

Country Status (12)

Country Link
US (1) US11491162B2 (es)
EP (1) EP3773549A1 (es)
JP (1) JP7391036B2 (es)
KR (1) KR20200143703A (es)
CN (1) CN112020356B (es)
AU (1) AU2019252324A1 (es)
BR (1) BR112020020656A2 (es)
CA (1) CA3096721A1 (es)
IL (1) IL277409A (es)
MX (1) MX2020009711A (es)
SG (1) SG11202009956WA (es)
WO (1) WO2019197367A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116507331A (zh) * 2020-06-15 2023-07-28 默克专利有限公司 Tlr7/8拮抗剂及其用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201206280D0 (en) * 2012-04-10 2012-05-23 Univ Dundee Anti-malarial agents

Also Published As

Publication number Publication date
WO2019197367A1 (en) 2019-10-17
US11491162B2 (en) 2022-11-08
JP2021521147A (ja) 2021-08-26
EP3773549A1 (en) 2021-02-17
JP7391036B2 (ja) 2023-12-04
SG11202009956WA (en) 2020-11-27
CN112020356A (zh) 2020-12-01
KR20200143703A (ko) 2020-12-24
IL277409A (en) 2020-11-30
CA3096721A1 (en) 2019-10-17
AU2019252324A1 (en) 2020-10-01
US20210023087A1 (en) 2021-01-28
CN112020356B (zh) 2024-04-05
BR112020020656A2 (pt) 2021-01-12

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