MX2020009385A - Mezcla de polimeros con resistencia a la influencia del etanol. - Google Patents

Mezcla de polimeros con resistencia a la influencia del etanol.

Info

Publication number
MX2020009385A
MX2020009385A MX2020009385A MX2020009385A MX2020009385A MX 2020009385 A MX2020009385 A MX 2020009385A MX 2020009385 A MX2020009385 A MX 2020009385A MX 2020009385 A MX2020009385 A MX 2020009385A MX 2020009385 A MX2020009385 A MX 2020009385A
Authority
MX
Mexico
Prior art keywords
sub
polymer
weight
monomers
ethanol
Prior art date
Application number
MX2020009385A
Other languages
English (en)
Inventor
Christian Meier
Jan Hendrik Schattka
Florian Hermes
Herbert Jung
Rosario Ferrand Jessica Del
Thomas Eurich
Thomas Endres
Original Assignee
Evonik Operations Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evonik Operations Gmbh filed Critical Evonik Operations Gmbh
Publication of MX2020009385A publication Critical patent/MX2020009385A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L33/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • C08L33/04—Homopolymers or copolymers of esters
    • C08L33/06—Homopolymers or copolymers of esters of esters containing only carbon, hydrogen and oxygen, which oxygen atoms are present only as part of the carboxyl radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/10—Esters
    • C08F220/12—Esters of monohydric alcohols or phenols
    • C08F220/16—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms
    • C08F220/18—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms with acrylic or methacrylic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/10—Esters
    • C08F220/34—Esters containing nitrogen, e.g. N,N-dimethylaminoethyl (meth)acrylate
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D133/00—Coating compositions based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Coating compositions based on derivatives of such polymers
    • C09D133/04—Homopolymers or copolymers of esters
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D133/00—Coating compositions based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Coating compositions based on derivatives of such polymers
    • C09D133/04—Homopolymers or copolymers of esters
    • C09D133/06—Homopolymers or copolymers of esters of esters containing only carbon, hydrogen and oxygen, the oxygen atom being present only as part of the carboxyl radical
    • C09D133/10—Homopolymers or copolymers of methacrylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/10—Esters
    • C08F220/12—Esters of monohydric alcohols or phenols
    • C08F220/16—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms
    • C08F220/18—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms with acrylic or methacrylic acids
    • C08F220/1808—C8-(meth)acrylate, e.g. isooctyl (meth)acrylate or 2-ethylhexyl (meth)acrylate

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Materials Engineering (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Preparation (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • General Preparation And Processing Of Foods (AREA)

Abstract

La invención se refiere a una mezcla de polímeros, que comprende de 10 a 90 % en peso de un polímero 1 y de 10 a 90 % en peso de un polímero 2, en la que los porcentajes en peso del polímero 1 y el polímero 2 suman 100 %, y en la que el polímero 1 es un polímero, polimerizado a partir de una mezcla de monómeros que comprende los monómeros (a1) 70-95 % en peso de un alquiléster C1-C12 de ácido acrílico o de ácido metacrílico, y (b1) 5-30 % en peso de un alquiléster C2-C8 de ácido acrílico o de ácido metacrílico con un grupo catiónico cuaternario en el grupo alquilo, y en la que el polímero 2 es un polímero polimerizado a partir de una mezcla de monómeros que comprende los monómeros (a2) 70 - 95 % en peso de un alquiléster C1 - C12 de ácido acrílico o de ácido metacrílico, y (c2) 5 - 30 % en peso de un hidroxi-alquiléster C2 - C6 de ácido acrílico o ácido metacrílico en la que en el polímero 1 los monómeros (a1) y (b1) suman de 98 a 100 % en peso, y más preferente a 100 %, y en la que en el polímero 2, independientemente del polímero 1, los monómeros (a2) y (c2) suman de 98 a 100 % en peso, más preferente 100 %.
MX2020009385A 2018-03-09 2019-02-27 Mezcla de polimeros con resistencia a la influencia del etanol. MX2020009385A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18160836 2018-03-09
PCT/EP2019/054817 WO2019170485A1 (en) 2018-03-09 2019-02-27 Polymer mixture with resistance against the influence of ethanol

Publications (1)

Publication Number Publication Date
MX2020009385A true MX2020009385A (es) 2020-10-28

Family

ID=61800258

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020009385A MX2020009385A (es) 2018-03-09 2019-02-27 Mezcla de polimeros con resistencia a la influencia del etanol.

Country Status (10)

Country Link
US (1) US20210007995A1 (es)
EP (1) EP3761967A1 (es)
JP (1) JP2021515778A (es)
KR (1) KR20200130369A (es)
CN (1) CN112469399A (es)
BR (1) BR112020018345A2 (es)
CA (1) CA3093077A1 (es)
IL (1) IL277180A (es)
MX (1) MX2020009385A (es)
WO (1) WO2019170485A1 (es)

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3438291A1 (de) 1984-10-19 1986-04-24 Röhm GmbH, 6100 Darmstadt Verfahren zur herstellung einer waessrigen ueberzugsmitteldispersion und ihre verwendung zum ueberziehen von arzneimitteln
DE19845358A1 (de) * 1998-10-02 2000-04-06 Roehm Gmbh Überzogene Arzneiformen mit kontrollierter Wirkstoffabgabe
JP3934383B2 (ja) * 2001-10-11 2007-06-20 アルフレッサファーマ株式会社 経口投与用製剤
DE102005024614A1 (de) * 2005-05-25 2006-11-30 Röhm Gmbh Verwendung von Polymermischungen zur Herstellung von überzogenen Arzneiformen sowie Arzneiform mit polymerem Mischüberzug
PL2187875T3 (pl) 2007-09-21 2013-01-31 Evonik Roehm Gmbh Kompozycja farmaceutyczna o zależnym od pH kontrolowanym uwalnianiu dla nieopioidów z odpornością przed wpływem etanolu
CA2699227C (en) 2007-09-21 2014-12-02 Evonik Roehm Gmbh Ph-dependent controlled release pharmaceutical opioid composition with resistance against the influence of ethanol
PL2341899T3 (pl) 2008-09-24 2015-05-29 Evonik Roehm Gmbh Opioidowa kompozycja farmaceutyczna o zależnym od pH kontrolowanym uwalnianiu z odpornością na działanie etanolu
CA2738197C (en) 2008-09-24 2016-01-05 Evonik Roehm Gmbh Ph-dependent controlled release pharmaceutical composition for non-opioids with resistance against the influence of ethanol
WO2010105672A1 (en) 2009-03-18 2010-09-23 Evonik Röhm Gmbh Controlled release pharmaceutical composition with resistance against the influence of ethanol employing a coating comprising neutral vinyl polymers and excipients
CN102365083A (zh) 2009-03-18 2012-02-29 赢创罗姆有限公司 采用包含聚合物混合物和赋形剂的包衣的具有耐乙醇影响的控释药物组合物
RU2649806C2 (ru) * 2011-06-17 2018-04-04 Эвоник Рем ГмбХ Желудочно-резистентная фармацевтическая или нутрицевтическая композиция с устойчивостью к воздействию этанола
US20160022591A1 (en) 2013-03-15 2016-01-28 Mylan Inc. Extended release pharmaceutical solid dosage formulations
EP3107529A1 (en) 2014-02-17 2016-12-28 Evonik Röhm GmbH Pharmaceutical or nutraceutical composition with sustained release characteristic and with resistance against the influence of ethanol
ES2786312T3 (es) * 2014-11-26 2020-10-09 Evonik Operations Gmbh Composición farmacéutica o nutracéutica con resistencia contra la influencia de etanol
BR112017025148A2 (pt) 2015-06-05 2018-08-07 Evonik Röhm Gmbh composição farmacêutica ou nutracêutica com resistência contra a influência do etanol

Also Published As

Publication number Publication date
BR112020018345A2 (pt) 2020-12-29
CA3093077A1 (en) 2019-09-12
WO2019170485A1 (en) 2019-09-12
JP2021515778A (ja) 2021-06-24
CN112469399A (zh) 2021-03-09
KR20200130369A (ko) 2020-11-18
US20210007995A1 (en) 2021-01-14
IL277180A (en) 2020-10-29
EP3761967A1 (en) 2021-01-13

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