MX2020006655A - Biorreactor y metodos relacionados. - Google Patents

Biorreactor y metodos relacionados.

Info

Publication number
MX2020006655A
MX2020006655A MX2020006655A MX2020006655A MX2020006655A MX 2020006655 A MX2020006655 A MX 2020006655A MX 2020006655 A MX2020006655 A MX 2020006655A MX 2020006655 A MX2020006655 A MX 2020006655A MX 2020006655 A MX2020006655 A MX 2020006655A
Authority
MX
Mexico
Prior art keywords
bioreactor
chamber
modular
related methods
impeller
Prior art date
Application number
MX2020006655A
Other languages
English (en)
Inventor
Bastien Mairesse
Josè Castillo
Sèbastien Jean- Pierre Michel RODRIGUEZ
Original Assignee
Univercells Tech S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univercells Tech S A filed Critical Univercells Tech S A
Publication of MX2020006655A publication Critical patent/MX2020006655A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/34—Internal compartments or partitions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/02—Membranes; Filters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/42—Integrated assemblies, e.g. cassettes or cartridges
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/44—Multiple separable units; Modules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/14—Scaffolds; Matrices
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/16—Particles; Beads; Granular material; Encapsulation
    • C12M25/18—Fixed or packed bed
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/18—Flow directing inserts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/18—Flow directing inserts
    • C12M27/20—Baffles; Ribs; Ribbons; Auger vanes

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Clinical Laboratory Science (AREA)
  • Immunology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

Se describe un aparato para el cultivo de células que incluye un biorreactor; el biorreactor puede ser modular y puede incluir en una cámara un lecho fijo, tal como un lecho fijo no estructurado o estructurado (tal como un lecho espiral) para el cultivo de células, con una columna de regreso dispuesta centralmente dentro de la cámara; el biorreactor modular puede incluir una pluralidad de lechos fijos estructurados dispuestos en una configuración apilada; el biorreactor modular puede incluir una cubierta exterior que forma un espacio para acondicionar (por ejemplo, aislar, calentar, enfriar) por lo menos una cámara en donde se cultivan las células; el biorreactor puede incluir también un propulsor con paletas radialmente encorvadas, y puede suspender también el propulsor para que pueda moverse de lado a lado y alinearse con un sistema de mando externo; se describen también métodos relacionados.
MX2020006655A 2017-12-20 2018-12-20 Biorreactor y metodos relacionados. MX2020006655A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762608261P 2017-12-20 2017-12-20
US201862733375P 2018-09-19 2018-09-19
US201862758152P 2018-11-09 2018-11-09
PCT/EP2018/086394 WO2019122239A1 (en) 2017-12-20 2018-12-20 Bioreactor and related methods

Publications (1)

Publication Number Publication Date
MX2020006655A true MX2020006655A (es) 2021-01-08

Family

ID=65013665

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020006655A MX2020006655A (es) 2017-12-20 2018-12-20 Biorreactor y metodos relacionados.

Country Status (12)

Country Link
US (3) US20210130760A1 (es)
EP (1) EP3728549A1 (es)
JP (2) JP7433232B2 (es)
KR (1) KR20200118416A (es)
CN (1) CN111801410A (es)
AU (1) AU2018386438A1 (es)
BR (1) BR112020012574A2 (es)
CA (1) CA3086283A1 (es)
MX (1) MX2020006655A (es)
RU (1) RU2020123777A (es)
SG (1) SG11202005815UA (es)
WO (1) WO2019122239A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI833022B (zh) 2019-05-28 2024-02-21 美商阿普賽德食品公司 用於製備可食用肉品之裝置及方法
AU2020300517A1 (en) * 2019-07-01 2022-02-03 Ology Bioservices, Inc. Method for cultivation of adherent cells in a multiparallel bioreactor
WO2021084077A1 (en) 2019-10-30 2021-05-06 Minaris Regenerative Medicine Gmbh Bioreactor for adherent cells
AU2020386085B2 (en) 2019-11-20 2022-08-11 Upside Foods, Inc. Apparatuses and systems for preparing a meat product
US20230348834A1 (en) * 2019-11-25 2023-11-02 Corning Incorporated Fixed bed bioreactor vessel and methods of using the same
WO2021110767A1 (en) * 2019-12-02 2021-06-10 Univercells Technologies S.A. Bioreactor with enhanced gas transfer and thermal regulation
WO2021228892A1 (en) * 2020-05-11 2021-11-18 Univercells Technologies S.A. Bioprocessing with improved measurement of process parameters, related apparatus and methods
WO2022064024A2 (en) * 2020-09-25 2022-03-31 Univercells Technologies S.A. Cell culturing vessel and related methods
JP2023547618A (ja) * 2020-10-23 2023-11-13 オロジー バイオサーヴィシズ、インク． ウイルスを細胞に感染させるための方法
EP4256024A1 (en) * 2020-12-02 2023-10-11 Univercells Technologies S.A. Structured monolithic fixed bed for cell culture, related bioreactor and methods of manufacturing
CN112375685A (zh) * 2020-12-04 2021-02-19 山东新华医疗器械股份有限公司 一种固定床生物反应器
US11752509B2 (en) 2021-06-17 2023-09-12 Upside Foods, Inc. Fluid dispenser for recovering material from a surface
KR102564121B1 (ko) * 2021-08-27 2023-08-08 주식회사 안머터리얼즈 다공성 물질의 제조를 위한 열팽창 반응기
WO2023170523A1 (en) * 2022-03-07 2023-09-14 Stemmedical A/S Closed system bioreactor for cell culturing
CN114736797A (zh) * 2022-03-30 2022-07-12 昆明柏特生物科技有限公司 一种细胞培养反应器
WO2024030477A1 (en) * 2022-08-03 2024-02-08 Corning Incorporated Rolled adherent cell culture substrates for uniform flow in fixed bed reactors
US11981884B2 (en) 2022-10-17 2024-05-14 Upside Foods, Inc. Pipe-based bioreactors for producing comestible meat products and methods of using the same
US20240182833A1 (en) 2022-11-18 2024-06-06 Univercells Technologies S.A. Systems and methods for recovering target biomolecules from fixed bed bioreactors
KR20240076276A (ko) 2022-11-23 2024-05-30 정순생 단체 급식 서비스 제공 장치 및 방법

Family Cites Families (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1376131A (en) 1971-02-09 1974-12-04 Nat Res Dev Improvements in and relating to cell culture systems
US3948732A (en) 1973-05-31 1976-04-06 Instrumentation Laboratory, Inc. Cell culture assembly
IL75554A (en) * 1985-06-18 1993-01-14 Yeda Res & Dev Matrix for cell cultivation in vitro
US5266476A (en) * 1985-06-18 1993-11-30 Yeda Research & Development Co., Ltd. Fibrous matrix for in vitro cell cultivation
US5786215A (en) 1987-05-20 1998-07-28 Baxter International Inc. Method for culturing animal cells
US4833083A (en) * 1987-05-26 1989-05-23 Sepragen Corporation Packed bed bioreactor
US5002890A (en) 1988-11-29 1991-03-26 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Spiral vane bioreactor
FR2679248A1 (fr) * 1991-07-19 1993-01-22 Commissariat Energie Atomique Bioreacteur et dispositif pour la culture de cellules animales.
JPH0678760A (ja) * 1992-09-03 1994-03-22 Kurabo Ind Ltd 接着性動物細胞の無血清培養法およびその培養器
US5563069A (en) 1992-04-24 1996-10-08 The Ohio State University Research Foundation Extractive fermentation using convoluted fibrous bed bioreactor
RU2050415C1 (ru) 1992-10-02 1995-12-20 Научно-производственное объединение биологического приборостроения "Биоприбор" РАН Биореактор для культивирования клеток на микроносителях
EP0682697A4 (en) * 1993-01-29 1997-07-30 New Brunswick Scientific Co METHOD AND APPARATUS FOR CULTURING ANCHOR AND SUSPENSION CELLS.
CA2372488C (en) * 1999-05-06 2009-01-27 Universite Laval Scalable bioreactor culture process and system for the maturation of conifer somatic embryos
JP4601746B2 (ja) 1999-10-25 2010-12-22 エイブル株式会社 三次元動物細胞培養装置及び培養方法
US6593136B1 (en) 2000-03-20 2003-07-15 Geo-Centers, Inc. Culturing cells in a chamber in a stack of chambers
US20030157676A1 (en) 2000-06-19 2003-08-21 Marc Arnaut Immobilising comprising a porous medium
ATE321848T1 (de) 2000-06-19 2006-04-15 Bekaert Sa Nv Immobilisierungsträger mit einem porösen medium
JP2004529740A (ja) 2001-06-15 2004-09-30 ジョーンズ ホプキンズ シンガポール ピーティーイー リミテッド 生体機能繊維
US6875605B1 (en) 2002-08-21 2005-04-05 Florida State University Research Foundation, Inc. Modular cell culture bioreactor and associated methods
EP1400585B1 (en) 2002-09-20 2011-09-14 Becton Dickinson and Company Roller bottle
DE10335130A1 (de) 2003-07-31 2005-02-24 Blue Membranes Gmbh Immobilisierung von Katalysatoren auf porösen Körpern auf Kohlenstoffbasis
ITMO20030081A1 (it) 2003-03-21 2004-09-22 Rand Srl Bioreattore, particolarmente per organi bioartificiali.
EP1788073B1 (en) 2004-08-17 2013-11-06 Kyushu Institute of Technology Porous sheet member for cell culture and, utilizing the same, bioreactor and culturing method
BE1016793A4 (fr) * 2005-10-04 2007-06-05 Artelis Procede de culture de cellules et dispositif permettant sa mise en oeuvre.
US8951784B2 (en) 2005-12-14 2015-02-10 Sepragen Corporation Cell culture bioreactor
US7682822B2 (en) 2006-03-31 2010-03-23 Aastrom Biosciences, Inc. Ex vivo generated tissue system
WO2008016673A2 (en) 2006-08-01 2008-02-07 Thefeinstein Institute For Medical Research Bioactive scaffolds
CN200940147Y (zh) 2006-08-30 2007-08-29 仪忠军 细胞贴壁培养用三层玻璃转瓶
US9217129B2 (en) 2007-02-09 2015-12-22 Massachusetts Institute Of Technology Oscillating cell culture bioreactor
CN101294136A (zh) * 2007-04-24 2008-10-29 博傲西腾医疗科技(上海)有限公司 生物人工肝细胞生长组件、人工肝反应器及其制备方法
US8198087B2 (en) 2007-07-30 2012-06-12 Sofradim Production Sas Tissue engineering support
RU2363729C1 (ru) 2008-02-18 2009-08-10 Федеральное государственное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФГУН ГНЦ ВБ "Вектор" Роспотребнадзора) Аппарат для суспензионного культивирования клеток тканей или микроорганизмов
WO2010032260A1 (en) * 2008-08-05 2010-03-25 Sameer Sudhir Kulkarni Stacked basket bioreactor for solid state fermentation
WO2010033820A1 (en) 2008-09-19 2010-03-25 University Of Louisville Research Foundation, Inc. Bioreactors, systems, and methods for vascularizing tissue constructs
GB0820779D0 (en) * 2008-11-13 2008-12-17 Artelis S A Cell culture device and method of culturing cells
WO2010069320A2 (en) * 2008-12-19 2010-06-24 Stobbe Tech A/S Biopharmaceutical plant in a column
US8507263B2 (en) 2009-08-07 2013-08-13 Maria Adelaide Asnaghi Rotating bioreactor
WO2011139957A1 (en) 2010-05-04 2011-11-10 Caridianbct, Inc. Method and apparatus for controlling a cell expansion apparatus
SG185434A1 (en) 2010-05-11 2012-12-28 Artelis S A Apparatus and methods for cell culture
WO2011161086A2 (en) 2010-06-23 2011-12-29 Stobbe Tech. A/S Device and method for industrial cultivation of cells
CN102344888B (zh) 2010-07-29 2014-08-20 凯洛斯环球有限公司 循环式光生物反应器
WO2012079086A2 (en) 2010-12-10 2012-06-14 Florida State University Research Foundation, Inc. Mesenchymal stem cells (msc) expansion methods and materials
MX2013011162A (es) * 2011-03-29 2015-01-16 Yongxin Zhang Sistema de biorreactor multifuncional y metodos para clasificacion de celulas y el cultivo.
US9657266B2 (en) 2011-04-15 2017-05-23 Pluristem Ltd. Methods and systems for harvesting cells
SE1130042A1 (sv) 2011-05-17 2012-11-18 Belagt nanofibernätverk för tredimensionell cellodling av neurala celler
RU117434U1 (ru) 2011-11-22 2012-06-27 Учреждение Российской академии медицинских наук Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний Сибирского отделения Российской академии медицинских наук (УРАМН НИИ КПССЗ СО РАМН) Устройство для культивирования клеток и заселения ими трубчатой тканеинженерной конструкции
WO2013079797A1 (en) 2011-12-01 2013-06-06 Kemira Oyj A material and method for immobilizing microbial cells
EP2885393A1 (en) 2012-08-20 2015-06-24 Terumo BCT, Inc. Method of loading and distributing cells in a bioreactor of a cell expansion system
JP2016504024A (ja) 2012-12-11 2016-02-12 ポール テクノロジー ユーケイ リミテッドＰａｌｌ Ｔｅｃｈｎｏｌｏｇｙ Ｕｋ Ｌｉｍｉｔｅｄ 細胞培養のための受容体
CN103865958B (zh) * 2012-12-13 2016-06-29 南京工业大学 一种采用固定化酵母细胞连续发酵生产乙醇的方法
US9273278B2 (en) 2013-01-07 2016-03-01 Cesco Bioengineering Co., Ltd. Large scale cell harvesting method for pack-bed culture device
US20140243995A1 (en) 2013-02-28 2014-08-28 The Massachusetts Institute Of Technology Stacked planar sheet tissue engineering scaffolds with 3d structural order
GB2520300A (en) 2013-11-15 2015-05-20 Univ Loughborough Cell Culture System
US9617506B2 (en) 2013-11-16 2017-04-11 Terumo Bct, Inc. Expanding cells in a bioreactor
WO2015118146A1 (en) 2014-02-10 2015-08-13 Univercells Nv System, apparatus and method for biomolecules production
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
WO2016121773A1 (ja) 2015-01-26 2016-08-04 宇部興産株式会社 ポリイミド多孔質膜を用いる細胞の大量培養方法、装置及びキット
MA41506A (fr) 2015-02-13 2017-12-19 Takeda Vaccines Inc Procédés de production de virus pour produire des vaccins
TWI672375B (zh) 2015-12-09 2019-09-21 財團法人工業技術研究院 細胞培養載體模組、生物反應器及細胞回收方法
ES2955959T3 (es) 2016-03-14 2023-12-11 Omnibrx Biotechnologies Private Ltd Un sistema de biorreactor y método del mismo
EP3452575A4 (en) 2016-05-05 2020-03-11 Terumo BCT, Inc. AUTOMATED MANUFACTURING AND COLLECTION
CA3023221A1 (en) 2016-05-05 2017-11-09 Southwest Research Institute Three-dimensional bioreactor for cell expansion and related applications
WO2017204563A1 (ko) 2016-05-24 2017-11-30 주식회사 아모라이프사이언스 세포배양 지지체용 원사, 이를 포함하는 세포배양 지지체용 원단
BE1024230B1 (fr) 2016-11-08 2017-12-20 Univercells Sa Production contenue de cellules et/ou de produits cellulaires
BE1024733B1 (fr) 2016-11-09 2018-06-14 Univercells Sa Matrice de croissance cellulaire
CN106635797A (zh) * 2017-03-15 2017-05-10 上海戈洛思生物科技有限公司 一种生物反应器
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
KR102174112B1 (ko) 2017-04-07 2020-11-04 에피본, 인크. 접종 및 배양용 시스템 및 방법
EP3713999A1 (en) 2017-11-21 2020-09-30 Corning Incorporated Dissolvable foam scaffolds for cell culture and methods of making the same
WO2019175442A1 (en) 2018-03-16 2019-09-19 Univercells S.A. Fixed bed sampler and related methods
CA3096510A1 (en) 2018-04-23 2019-10-31 Univercells Technologies S.A. Bioreactor with freeze-thaw capabilities to enhance product recovery and related methods
CN108315258A (zh) 2018-05-10 2018-07-24 章毅 增大细胞培养面积的细胞培养滚瓶及其应用

Also Published As

Publication number Publication date
EP3728549A1 (en) 2020-10-28
WO2019122239A1 (en) 2019-06-27
JP2021508445A (ja) 2021-03-11
US20210130760A1 (en) 2021-05-06
CN111801410A (zh) 2020-10-20
AU2018386438A1 (en) 2020-08-06
US20230272324A1 (en) 2023-08-31
US11680237B2 (en) 2023-06-20
US20220396754A1 (en) 2022-12-15
SG11202005815UA (en) 2020-07-29
CA3086283A1 (en) 2019-06-27
KR20200118416A (ko) 2020-10-15
RU2020123777A (ru) 2022-01-21
JP7433232B2 (ja) 2024-02-19
JP2024023339A (ja) 2024-02-21
BR112020012574A2 (pt) 2020-11-24

Similar Documents

Publication Publication Date Title
MX2020006655A (es) Biorreactor y metodos relacionados.
BR112017018224A2 (pt) métodos para manipulação de célula t alogênica para aumentar sua persistência e/ou implante em pacientes
WO2016090178A3 (en) Processes for producing exosomes in reduced oxygen culture conditions
SG10201900323SA (en) Method for inducing t cells for cell-based immunotherapy from pluripotent stem cells
SG10201906673WA (en) Artificial nucleic acid molecules
TW201614753A (en) Substrate Processing Apparatus, Gas Introduction Shaft and Gas Supply Plate
PH12019500524A1 (en) Biomass treatment process and apparatus
WO2011116955A3 (de) Inkubatoreinrichtung und verfahren zu deren betrieb
EP2899005A3 (en) Arrangement and method for curing concrete products
EA201291185A1 (ru) Способ обработки сподумена
MX2019000022A (es) Células veto generadas a partir de linfocitos t de memoria.
EP4234569A3 (en) Method and use for continuously inactivating a virus during manufacture of a biological product
MX2019005326A (es) Sistema para la produccion de celulas y/o productos de celulas.
WO2013006681A3 (en) Bioreactors circulation apparatus, system and method
MX2018006373A (es) Produccion de virus en cultivos celulares.
MX2017000702A (es) Proceso para la acetilacion de madera.
NZ715000A (en) A system and a method for processing plastic, and plastic processed therefrom
GB2558162A8 (en) Toroidal bed reactor
MX2018015900A (es) Elementos reguladores de planta y metodos para usarlos.
Khomich et al. Electrohydrodynamic flow induced by dielectric barrier discharge for gas laser circulation system
MX2016010130A (es) Un microorganismo modificado con capacidad de sintesis de biomasa mejorada y un metodo para el mismo campo.
MY183785A (en) Improved toroidal bed reactor
MX2016013363A (es) Metodo para aumentar la capacidad de sintesis de biomasa de microorganismos y microorganismos modificados a partir de ellos.
Liang et al. Reply to Dr. Witwer's letter to the editor
Dremin et al. Electrohydrodynamic flow application in gas discharge laser circulation system