MX2020004674A - Anticuerpos contra alfa-sinucleina y usos de los mismos. - Google Patents
Anticuerpos contra alfa-sinucleina y usos de los mismos.Info
- Publication number
- MX2020004674A MX2020004674A MX2020004674A MX2020004674A MX2020004674A MX 2020004674 A MX2020004674 A MX 2020004674A MX 2020004674 A MX2020004674 A MX 2020004674A MX 2020004674 A MX2020004674 A MX 2020004674A MX 2020004674 A MX2020004674 A MX 2020004674A
- Authority
- MX
- Mexico
- Prior art keywords
- synuclein
- antibodies
- aggregates
- antibody
- diagnosis
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2835—Movement disorders, e.g. Parkinson, Huntington, Tourette
Abstract
La presente invención proporciona un anticuerpo anti-a-sinucleína que de manera preferencial reconoce agregados de a-sinucleína, y uso de detección, diagnóstico y/o tratamiento o prevención de diversas enfermedades causadas por acumulación de agregados de a-sinucleína y sus enfermedades de síntomas relacionadas usando el anticuerpo anti-a-sinucleína.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762588018P | 2017-11-17 | 2017-11-17 | |
US201862687848P | 2018-06-21 | 2018-06-21 | |
PCT/KR2018/014123 WO2019098763A2 (ko) | 2017-11-17 | 2018-11-16 | 알파-시누클레인에 대한 항체 및 그 용도 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2020004674A true MX2020004674A (es) | 2020-08-13 |
Family
ID=66537805
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2020004674A MX2020004674A (es) | 2017-11-17 | 2018-11-16 | Anticuerpos contra alfa-sinucleina y usos de los mismos. |
Country Status (10)
Country | Link |
---|---|
US (1) | US20230279085A1 (es) |
EP (1) | EP3725802A4 (es) |
JP (2) | JP7173618B2 (es) |
KR (1) | KR102508933B1 (es) |
CN (1) | CN111356701B (es) |
AU (2) | AU2018370279B2 (es) |
BR (1) | BR112020009707A2 (es) |
CA (1) | CA3082559A1 (es) |
MX (1) | MX2020004674A (es) |
WO (1) | WO2019098763A2 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112019013953A2 (pt) * | 2017-01-06 | 2020-02-11 | Abl Bio Inc. | Anticorpo anti-a-syn e uso do mesmo |
CA3049110A1 (en) * | 2017-01-06 | 2018-07-12 | Abl Bio Inc. | Anti-.alpha.-syn antibody and use thereof |
CA3051839A1 (en) | 2017-02-17 | 2018-08-23 | Bristol-Myers Squibb Company | Antibodies to alpha-synuclein and uses thereof |
PE20220516A1 (es) * | 2019-06-14 | 2022-04-07 | Abl Bio Inc | ANTICUERPO BIESPECIFICO CONTRA (alfa)-SYN/IGF1R Y USO DEL MISMO |
EP4229082A1 (en) * | 2020-10-16 | 2023-08-23 | AC Immune SA | Antibodies binding to alpha-synuclein for therapy and diagnosis |
TW202309076A (zh) * | 2021-05-12 | 2023-03-01 | 南韓商Abl生物公司 | 用於治療α-突觸核蛋白病之抗體 |
CN113912714B (zh) * | 2021-12-15 | 2022-02-22 | 北京凯祥弘康生物科技有限公司 | 特异性结合α-突触核蛋白的抗体及其应用 |
CN113912713B (zh) * | 2021-12-15 | 2022-03-08 | 北京凯祥弘康生物科技有限公司 | 一种抗α-突触核蛋白的单克隆抗体及其应用 |
WO2024044709A2 (en) * | 2022-08-24 | 2024-02-29 | The Research Foundation For The State University Of New York | Anti-monomethyl auristatin antibodies and antibody fragments |
CN117607463B (zh) * | 2024-01-23 | 2024-04-09 | 杭州华得森生物技术有限公司 | 一种循环肿瘤细胞egfr免疫显色检测试剂 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5260203A (en) | 1986-09-02 | 1993-11-09 | Enzon, Inc. | Single polypeptide chain binding molecules |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
PL2949666T3 (pl) | 2008-12-19 | 2019-07-31 | Biogen International Neuroscience Gmbh | Ludzkie przeciwciała przeciwko alfa-synukleinie |
CN106397588B (zh) | 2010-02-26 | 2020-09-08 | 生命北极神经科学公司 | 原细纤维结合抗体及其治疗和诊断帕金森氏症、路易体痴呆和其他α-共核蛋白病的应用 |
EP2366714A1 (en) * | 2010-03-03 | 2011-09-21 | Dr. Rentschler Holding GmbH & Co. KG | Naturally occuring autoantibodies against alpha-synuclein that inhibit the aggregation and cytotoxicity of alpha-synuclein |
SI2723379T1 (sl) * | 2011-06-23 | 2019-03-29 | Biogen International Neuroscience Gmbh | Molekule, ki se vežejo ma anti alfa-sinuklein |
US9534044B2 (en) | 2013-02-28 | 2017-01-03 | United Arab Emirates University | Alpha-synuclein antibodies and uses thereof |
GB201512203D0 (en) * | 2015-07-13 | 2015-08-19 | Lundbeck & Co As H | Agents,uses and methods |
CA3049110A1 (en) * | 2017-01-06 | 2018-07-12 | Abl Bio Inc. | Anti-.alpha.-syn antibody and use thereof |
-
2018
- 2018-11-16 US US16/759,937 patent/US20230279085A1/en active Pending
- 2018-11-16 AU AU2018370279A patent/AU2018370279B2/en active Active
- 2018-11-16 MX MX2020004674A patent/MX2020004674A/es unknown
- 2018-11-16 WO PCT/KR2018/014123 patent/WO2019098763A2/ko unknown
- 2018-11-16 BR BR112020009707-1A patent/BR112020009707A2/pt unknown
- 2018-11-16 EP EP18879299.8A patent/EP3725802A4/en active Pending
- 2018-11-16 KR KR1020180142112A patent/KR102508933B1/ko active IP Right Grant
- 2018-11-16 CA CA3082559A patent/CA3082559A1/en active Pending
- 2018-11-16 CN CN201880074418.3A patent/CN111356701B/zh active Active
- 2018-11-16 JP JP2020527742A patent/JP7173618B2/ja active Active
-
2022
- 2022-10-12 AU AU2022252753A patent/AU2022252753A1/en active Pending
- 2022-10-27 JP JP2022172107A patent/JP2023017837A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
WO2019098763A2 (ko) | 2019-05-23 |
JP2023017837A (ja) | 2023-02-07 |
US20230279085A1 (en) | 2023-09-07 |
AU2022252753A1 (en) | 2023-01-19 |
CN111356701A (zh) | 2020-06-30 |
WO2019098763A3 (ko) | 2019-07-11 |
AU2018370279A1 (en) | 2020-05-28 |
EP3725802A2 (en) | 2020-10-21 |
CN111356701B (zh) | 2023-11-21 |
JP7173618B2 (ja) | 2022-11-16 |
JP2021503288A (ja) | 2021-02-12 |
WO2019098763A9 (ko) | 2019-08-29 |
BR112020009707A2 (pt) | 2020-10-13 |
CA3082559A1 (en) | 2019-05-23 |
EP3725802A4 (en) | 2021-08-11 |
KR20190057004A (ko) | 2019-05-27 |
KR102508933B1 (ko) | 2023-03-13 |
AU2018370279B2 (en) | 2022-11-03 |
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