MX2020000154A - Composiciones y métodos para inhibir la expresión de hmgb1. - Google Patents
Composiciones y métodos para inhibir la expresión de hmgb1.Info
- Publication number
- MX2020000154A MX2020000154A MX2020000154A MX2020000154A MX2020000154A MX 2020000154 A MX2020000154 A MX 2020000154A MX 2020000154 A MX2020000154 A MX 2020000154A MX 2020000154 A MX2020000154 A MX 2020000154A MX 2020000154 A MX2020000154 A MX 2020000154A
- Authority
- MX
- Mexico
- Prior art keywords
- hmgb1 expression
- compositions
- methods
- oligonucleotides
- hepatocytes
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/531—Stem-loop; Hairpin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/533—Physical structure partially self-complementary or closed having a mismatch or nick in at least one of the strands
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
Esta divulgación ser refiere a los oligonucleótidos, las composiciones y métodos útiles para reducir la expresión de HMGB1, particularmente en hepatocitos; los oligonucleótidos descritos para la reducción de la expresión HMGB1 pueden ser de doble cadena o cadena simple y pueden modificarse para las características mejoradas tales como mayor resistencia a nucleasas y menor inmunogenicidad; los oligonucleótidos descritos para la reducción de la expresión de HMGB1 también puede diseñarse para incluir ligandos dirigidos para dirigir una célula u órgano particular, tal como los hepatocitos del hígado y puede usarse para tratar la fibrosis hepática y afecciones relacionadas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762526971P | 2017-06-29 | 2017-06-29 | |
PCT/US2018/040410 WO2019006375A1 (en) | 2017-06-29 | 2018-06-29 | COMPOSITIONS AND METHODS FOR INHIBITING HMGB1 EXPRESSION |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2020000154A true MX2020000154A (es) | 2020-07-22 |
Family
ID=64735107
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2020000154A MX2020000154A (es) | 2017-06-29 | 2018-06-29 | Composiciones y métodos para inhibir la expresión de hmgb1. |
Country Status (10)
Country | Link |
---|---|
US (2) | US10675295B2 (es) |
EP (1) | EP3645013A4 (es) |
JP (1) | JP2020529197A (es) |
KR (1) | KR20200023427A (es) |
CN (1) | CN111050776A (es) |
AU (1) | AU2018294415A1 (es) |
CA (1) | CA3068630A1 (es) |
IL (2) | IL271680B (es) |
MX (1) | MX2020000154A (es) |
WO (1) | WO2019006375A1 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111050776A (zh) | 2017-06-29 | 2020-04-21 | 迪克纳制药公司 | 用于抑制hmgb1表达的组合物和方法 |
CA3094008A1 (en) * | 2018-04-13 | 2019-10-17 | Dicerna Pharmaceuticals, Inc. | Double-stranded nucleic acid inhibitor molecules modified with tm-increasing nucleotides |
MX2021007001A (es) * | 2018-12-12 | 2021-10-13 | Dicerna Pharmaceuticals Inc | Moleculas inhibidoras de acido nucleico de cadena doble que contienen un tribucle. |
MX2021007855A (es) * | 2018-12-28 | 2021-10-26 | Dicerna Pharmaceuticals Inc | Composiciones y metodos para inhibir la expresion de hmgb1. |
TW202300645A (zh) * | 2021-04-14 | 2023-01-01 | 美商戴瑟納製藥股份有限公司 | 用於調節pnpla3表現之組合物及方法 |
BR112023021614A2 (pt) | 2021-04-19 | 2024-01-16 | Dicerna Pharmaceuticals Inc | Composições e métodos para inibir a expressão da subfamília 1 de receptores nucleares, grupo h, membro 3 (nr1h3) |
WO2023027759A1 (en) * | 2021-08-25 | 2023-03-02 | Dicerna Pharmaceuticals, Inc. | Compositions and methods for inhibiting αlpha-1 antitrypsin expression |
WO2024061202A1 (zh) * | 2022-09-20 | 2024-03-28 | 北京福元医药股份有限公司 | 用于抑制hmgb1基因表达的双链核糖核酸及其修饰物、缀合物和用途 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7250496B2 (en) * | 2002-11-14 | 2007-07-31 | Rosetta Genomics Ltd. | Bioinformatically detectable group of novel regulatory genes and uses thereof |
US20080311122A1 (en) | 2005-11-28 | 2008-12-18 | Medimmune, Llc | Antagonists of Hmgb1 and/or Rage and Methods of Use Thereof |
US8178503B2 (en) * | 2006-03-03 | 2012-05-15 | International Business Machines Corporation | Ribonucleic acid interference molecules and binding sites derived by analyzing intergenic and intronic regions of genomes |
US20110081362A1 (en) * | 2008-01-31 | 2011-04-07 | The Brigham And Women's Hospital, Inc. | Treatment of cancer |
ES2708944T3 (es) * | 2008-09-22 | 2019-04-12 | Dicerna Pharmaceuticals Inc | Composiciones y métodos para la inhibición específica de la expresión de genes por DSRNA que tenga modificaciones |
WO2011007876A1 (ja) | 2009-07-16 | 2011-01-20 | Necソフト株式会社 | Hmgb1結合核酸分子およびその用途 |
US9186371B2 (en) | 2010-09-17 | 2015-11-17 | Japan Science And Technology Agency | Inhibitor of HMGB protein-mediated immune response activation, and screening method |
WO2014028494A1 (en) * | 2012-08-13 | 2014-02-20 | The Regents Of The University Of California | Detecting and treating liver damage |
JP6688292B2 (ja) * | 2014-10-10 | 2020-04-28 | ダイセルナ ファーマシューティカルズ, インコーポレイテッドDicerna Pharmaceuticals, Inc. | 乳酸デヒドロゲナーゼ及びその薬剤の治療的阻害 |
DK3234132T3 (da) * | 2014-12-15 | 2019-08-26 | Dicerna Pharmaceuticals Inc | Ligand-modificerede dobbeltstrengede nukleinsyrer |
WO2017079227A1 (en) | 2015-11-05 | 2017-05-11 | University Of Connecticut | Compositions and methods for the treatment of liver fibrosis |
CN106244589A (zh) * | 2016-08-01 | 2016-12-21 | 中国人民解放军第四军医大学 | 靶向hmgb1基因的rna干扰片段及其应用 |
CN111050776A (zh) | 2017-06-29 | 2020-04-21 | 迪克纳制药公司 | 用于抑制hmgb1表达的组合物和方法 |
CA3086343A1 (en) * | 2017-12-18 | 2019-06-27 | Alnylam Pharmaceuticals, Inc. | High mobility group box-1 (hmgb1) irna compositions and methods of use thereof |
US11147547B2 (en) | 2017-12-21 | 2021-10-19 | Cilag Gmbh International | Surgical stapler comprising storable cartridges having different staple sizes |
MX2021007855A (es) | 2018-12-28 | 2021-10-26 | Dicerna Pharmaceuticals Inc | Composiciones y metodos para inhibir la expresion de hmgb1. |
-
2018
- 2018-06-29 CN CN201880056295.0A patent/CN111050776A/zh active Pending
- 2018-06-29 IL IL271680A patent/IL271680B/en unknown
- 2018-06-29 KR KR1020207002542A patent/KR20200023427A/ko not_active Application Discontinuation
- 2018-06-29 IL IL295086A patent/IL295086A/en unknown
- 2018-06-29 MX MX2020000154A patent/MX2020000154A/es unknown
- 2018-06-29 US US16/024,355 patent/US10675295B2/en active Active
- 2018-06-29 CA CA3068630A patent/CA3068630A1/en active Pending
- 2018-06-29 EP EP18824412.3A patent/EP3645013A4/en active Pending
- 2018-06-29 AU AU2018294415A patent/AU2018294415A1/en active Pending
- 2018-06-29 JP JP2019572382A patent/JP2020529197A/ja active Pending
- 2018-06-29 WO PCT/US2018/040410 patent/WO2019006375A1/en unknown
-
2020
- 2020-04-30 US US16/863,081 patent/US11478501B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
CA3068630A1 (en) | 2019-01-03 |
JP2020529197A (ja) | 2020-10-08 |
US20190000870A1 (en) | 2019-01-03 |
IL271680A (en) | 2020-02-27 |
US11478501B2 (en) | 2022-10-25 |
CN111050776A (zh) | 2020-04-21 |
KR20200023427A (ko) | 2020-03-04 |
US10675295B2 (en) | 2020-06-09 |
AU2018294415A1 (en) | 2020-01-16 |
EP3645013A4 (en) | 2021-07-21 |
IL271680B (en) | 2022-09-01 |
US20200297754A1 (en) | 2020-09-24 |
EP3645013A1 (en) | 2020-05-06 |
IL295086A (en) | 2022-09-01 |
WO2019006375A1 (en) | 2019-01-03 |
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