MX2019015212A - Tinostamustine for use in treating sarcoma. - Google Patents

Tinostamustine for use in treating sarcoma.

Info

Publication number
MX2019015212A
MX2019015212A MX2019015212A MX2019015212A MX2019015212A MX 2019015212 A MX2019015212 A MX 2019015212A MX 2019015212 A MX2019015212 A MX 2019015212A MX 2019015212 A MX2019015212 A MX 2019015212A MX 2019015212 A MX2019015212 A MX 2019015212A
Authority
MX
Mexico
Prior art keywords
tinostamustine
treating sarcoma
sarcoma
treating
sarcomain
Prior art date
Application number
MX2019015212A
Other languages
Spanish (es)
Inventor
Thomas Jorg Mehrling
Original Assignee
Euro Celtique Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro Celtique Sa filed Critical Euro Celtique Sa
Publication of MX2019015212A publication Critical patent/MX2019015212A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

There is provided tinostamustine or a pharmaceutically acceptable salt thereof for use in the treatment of sarcomain a patient in need thereof.
MX2019015212A 2017-06-13 2018-06-13 Tinostamustine for use in treating sarcoma. MX2019015212A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1709403.8A GB201709403D0 (en) 2017-06-13 2017-06-13 Compounds for treating sarcoma
PCT/EP2018/065668 WO2018229133A1 (en) 2017-06-13 2018-06-13 Tinostamustine for use in treating sarcoma

Publications (1)

Publication Number Publication Date
MX2019015212A true MX2019015212A (en) 2020-08-17

Family

ID=59358374

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019015212A MX2019015212A (en) 2017-06-13 2018-06-13 Tinostamustine for use in treating sarcoma.

Country Status (14)

Country Link
US (2) US11576899B2 (en)
EP (1) EP3638232B1 (en)
JP (1) JP2020523355A (en)
KR (1) KR20200014791A (en)
AR (1) AR112144A1 (en)
AU (1) AU2018285822B2 (en)
BR (1) BR112019026463A2 (en)
CA (1) CA3067065A1 (en)
ES (1) ES2970224T3 (en)
GB (1) GB201709403D0 (en)
IL (1) IL271020A (en)
MX (1) MX2019015212A (en)
TW (1) TW201919618A (en)
WO (1) WO2018229133A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201409485D0 (en) 2014-05-28 2014-07-09 Euro Celtique Sa Pharmaceutical composition
GB201409471D0 (en) 2014-05-28 2014-07-09 Euro Celtique Sa Pharmaceutical composition
CA3040155C (en) 2016-10-11 2024-01-16 Euro-Celtique S.A. Compound for use in the treatment of hodgkin lymphoma
GB201709402D0 (en) 2017-06-13 2017-07-26 Euro Celtique Sa Compounds for treating t-pll
GB201709405D0 (en) 2017-06-13 2017-07-26 Euro Celtique Sa Compounds for treating ovarian cancer
GB201709403D0 (en) 2017-06-13 2017-07-26 Euro Celtique Sa Compounds for treating sarcoma
GB201709406D0 (en) 2017-06-13 2017-07-26 Euro-Cletique S A Compounds for treating TNBC

Family Cites Families (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE34727C (en) Ch. H. TH. HAVEMANN in Paris, 16 rue Bleue Process for the direct extraction of metallic lead
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US6407079B1 (en) 1985-07-03 2002-06-18 Janssen Pharmaceutica N.V. Pharmaceutical compositions containing drugs which are instable or sparingly soluble in water and methods for their preparation
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
KR0166088B1 (en) 1990-01-23 1999-01-15 . Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
US5369108A (en) 1991-10-04 1994-11-29 Sloan-Kettering Institute For Cancer Research Potent inducers of terminal differentiation and methods of use thereof
GB9126209D0 (en) 1991-12-10 1992-02-12 Orion Yhtymae Oy Drug formulations for parenteral use
US5602112A (en) 1992-06-19 1997-02-11 Supergen, Inc. Pharmaceutical formulation
US5882941A (en) 1994-05-04 1999-03-16 Massachusette Institute Of Technology Programmable genotoxic agents and uses therefor
US6046177A (en) 1997-05-05 2000-04-04 Cydex, Inc. Sulfoalkyl ether cyclodextrin based controlled release solid pharmaceutical formulations
US5874418A (en) 1997-05-05 1999-02-23 Cydex, Inc. Sulfoalkyl ether cyclodextrin based solid pharmaceutical formulations and their use
AU750207B2 (en) 1997-06-13 2002-07-11 Cydex Pharmaceuticals, Inc. Polar drug or prodrug compositions with extended shelf-life storage and a method of making thereof
US6214852B1 (en) 1998-10-21 2001-04-10 Bristol-Myers Squibb Company N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases
US6392053B2 (en) 1999-12-15 2002-05-21 Bristol-Myers Squibb Company Process for preparing arylacetylaminothiazoles
US20020076409A1 (en) 2000-07-12 2002-06-20 March Carl J. Method for treating cancer
PE20020354A1 (en) 2000-09-01 2002-06-12 Novartis Ag HYDROXAMATE COMPOUNDS AS HISTONE-DESACETILASE (HDA) INHIBITORS
ATE430567T1 (en) 2000-09-29 2009-05-15 Topotarget Uk Ltd CARBAMINIC ACID DERIVATIVES CONTAINING AN AMIDE GROUP FOR THE TREATMENT OF MALARIA
AU2002243231A1 (en) 2000-11-21 2002-07-24 Wake Forest University Method of treating autoimmune diseases
CN1764648A (en) 2003-01-13 2006-04-26 安斯泰来制药有限公司 hydroxamid acid derivatives as histone deacetylase (HDAC) inhibitors
EP1599449A2 (en) 2003-02-25 2005-11-30 TopoTarget UK Limited Carbamic acid compounds comprising a bicyclic heteroaryl group as hdac inhibitors
WO2005013958A1 (en) 2003-08-07 2005-02-17 Novartis Ag Histone deacetylase inhibitors as immunosuppressants
WO2005097747A1 (en) 2004-04-05 2005-10-20 Aton Pharma, Inc. Histone deacetylase inhibitor prodrugs
WO2007134169A2 (en) 2006-05-10 2007-11-22 Nuada, Llc Indole, benzimidazole, and benzolactam boronic acid compounds, analogs thereof and methods of use thereof
US8436190B2 (en) 2005-01-14 2013-05-07 Cephalon, Inc. Bendamustine pharmaceutical compositions
CN102579417B (en) 2005-05-13 2014-11-26 托波塔吉特英国有限公司 Pharmaceutical formulations of HDAC inhibitors
US8455471B2 (en) 2006-10-20 2013-06-04 Icos Corporation Compositions of CHK1 inhibitors and cyclodextrin
GB0621160D0 (en) 2006-10-24 2006-12-06 Imp College Innovations Ltd Compounds and uses thereof
MX2009005292A (en) 2006-11-20 2009-08-13 Cephalon Inc Method of radio-sensitizing tumors using a radio-sensitizing agent.
CN101084876A (en) 2007-07-11 2007-12-12 济南康泉医药科技有限公司 Anti-cancer composition containing bendamustine
TW200922564A (en) 2007-09-10 2009-06-01 Curis Inc CDK inhibitors containing a zinc binding moiety
US20090131367A1 (en) 2007-11-19 2009-05-21 The Regents Of The University Of Colorado Combinations of HDAC Inhibitors and Proteasome Inhibitors
US8987468B2 (en) 2008-02-04 2015-03-24 The Translational Genomics Research Institute Compounds, pharmaceutical compositions and methods of use of hydroxamic acid derivatives
WO2010036702A1 (en) 2008-09-25 2010-04-01 Cephalon, Inc. Liquid formulations of bendamustine
JP5773874B2 (en) 2008-10-08 2015-09-02 セファロン、インク． Method for preparing bendamustine
WO2010075542A1 (en) 2008-12-23 2010-07-01 Curis, Inc. Cdk inhibitors
EP2389375B1 (en) 2009-01-23 2015-05-20 Euro-Celtique S.A. Hydroxamic acid derivatives
NO2792369T3 (en) 2009-02-25 2018-09-15
US8603521B2 (en) 2009-04-17 2013-12-10 Pharmacyclics, Inc. Formulations of histone deacetylase inhibitor and uses thereof
WO2011017448A1 (en) 2009-08-05 2011-02-10 The Trustees Of The University Of Pennsylvania Use of histone deacetylase inhibitors for treatment of autoimmune diseases
CN101928234B (en) 2010-01-15 2012-12-12 北京欧凯纳斯科技有限公司 6/7-(hetero)aryl-N-hydroxyl hexanamide/heptamide compounds and method for preparing same
US20130030237A1 (en) 2010-04-15 2013-01-31 Charles Theuer Potentiation of anti-cancer activity through combination therapy with ber pathway inhibitors
ES2605586T3 (en) 2010-04-16 2017-03-15 Cellact Pharma Gmbh Etoposide analogues for the treatment of metastatic tumors
JO3659B1 (en) 2010-06-02 2020-08-27 Astellas Deutschland Gmbh Oral dosage forms of bendamustine and therapeutic use thereof
US8748470B2 (en) 2011-03-17 2014-06-10 The University Of Chicago Methods for treating ovarian cancer by inhibiting fatty acid binding proteins
SG2014014419A (en) 2011-09-13 2014-07-30 Pharmacyclics Inc Formulations of histone deacetylase inhibitor in combination with bendamustine and uses thereof
CN102993102B (en) 2011-09-16 2016-08-24 杭州民生药业有限公司 The synthetic method of [1-methyl-2-(hydroxamic acid base in 7 '-heptan)-5-N, N-bis-(2 '-chloroethyl)]-1H-benzimidazole
KR20140078619A (en) * 2011-09-18 2014-06-25 유로-셀띠끄 소시에떼 아노님 Pharmaceutical compositions
SI2760860T1 (en) 2011-09-28 2017-04-26 Euro-Celtique S.A. Nitrogen mustard derivatives
AR092790A1 (en) 2012-02-01 2015-05-06 Euro Celtique Sa BENCIMIDAZOLIC DERIVATIVES OF HYDROXAMIC ACID
EP3076963A4 (en) 2013-12-06 2017-09-13 Millennium Pharmaceuticals, Inc. Combination of aurora kinase inhibitors and anti-cd30 antibodies
NZ630314A (en) 2014-02-18 2016-03-31 Celgene Corp Combination therapy for hematological malignancies
GB201409471D0 (en) 2014-05-28 2014-07-09 Euro Celtique Sa Pharmaceutical composition
GB201409485D0 (en) 2014-05-28 2014-07-09 Euro Celtique Sa Pharmaceutical composition
GB201409488D0 (en) 2014-05-28 2014-07-09 Euro Celtique Sa Pharmaceutical composition
WO2016087950A1 (en) 2014-12-05 2016-06-09 University of Modena and Reggio Emilia Combinations of histone deacetylase inhibitors and bendamustine for use in the treatment of lymphoma
CN106580971B (en) 2015-10-20 2019-11-12 杭州梯诺医药科技有限公司 A kind of pharmaceutical composition and preparation method thereof
US20180098969A1 (en) 2016-10-11 2018-04-12 Purdue Pharmaceutical Products L.P. Hodgkin lymphoma therapy
CA3040155C (en) 2016-10-11 2024-01-16 Euro-Celtique S.A. Compound for use in the treatment of hodgkin lymphoma
GB201709405D0 (en) 2017-06-13 2017-07-26 Euro Celtique Sa Compounds for treating ovarian cancer
GB201709402D0 (en) 2017-06-13 2017-07-26 Euro Celtique Sa Compounds for treating t-pll
GB201709406D0 (en) 2017-06-13 2017-07-26 Euro-Cletique S A Compounds for treating TNBC
GB201709403D0 (en) 2017-06-13 2017-07-26 Euro Celtique Sa Compounds for treating sarcoma
AU2019402158A1 (en) 2018-12-18 2021-06-10 Mundipharma International Corporation Limited Compounds for treating lymphoma or a T-cell malignant disease

Also Published As

Publication number Publication date
EP3638232C0 (en) 2023-12-13
US20200113870A1 (en) 2020-04-16
ES2970224T3 (en) 2024-05-27
AR112144A1 (en) 2019-09-25
AU2018285822A1 (en) 2019-12-19
IL271020A (en) 2020-01-30
EP3638232B1 (en) 2023-12-13
KR20200014791A (en) 2020-02-11
US20230277507A1 (en) 2023-09-07
US11576899B2 (en) 2023-02-14
CA3067065A1 (en) 2018-12-20
GB201709403D0 (en) 2017-07-26
TW201919618A (en) 2019-06-01
EP3638232A1 (en) 2020-04-22
JP2020523355A (en) 2020-08-06
BR112019026463A2 (en) 2020-07-14
WO2018229133A1 (en) 2018-12-20
AU2018285822B2 (en) 2024-01-04

Similar Documents

Publication Publication Date Title
MX2019015212A (en) Tinostamustine for use in treating sarcoma.
MX2019015207A (en) Tinostamustine for use in treating ovarian cancer.
MX2022007221A (en) Valproic acid for the treatment or prevention of pathological conditions associated with excess fibrin deposition and/or thrombus formation.
IL276398A (en) Combination therapy for the treatment of mastocytosis
MX2018007074A (en) Modulators of kv3 channels to treat pain.
MX2019015211A (en) Compounds for treating tnbc.
JOP20190056B1 (en) Compounds for use in the treatment of acute kidney injury
MX2020008195A (en) Compounds for the treatment of pain.
CY1119532T1 (en) (S) -PYRILDOL AND THE PHARMACEUTALLY ACCEPTABLE SALTS FOR USE IN MEDICINE
MX2017013047A (en) Treatment of pain.
CY1119522T1 (en) (R) - PILINDOL AND THE PHARMACEUTICALALLY ACCEPTABLE SALTS FOR USE IN MEDICINE
IL281770A (en) Indane derivatives for use in the treatment of bacterial infection
NZ747201A (en) (+)-azasetron for use in the treatment of ear disorders
MX2018001355A (en) Use of 2-(5s-methyl-2-oxo-4r-phenyl-pyrrolidin-1-yl)-acetamide in the treatment of seizures.
PH12016502107A1 (en) Combination of brexpiprazole and nalmefene and use thereof for treating substance-related disorders
SG10201903630UA (en) Iminosugars useful for the treatment of viral diseases
PH12016502111A1 (en) Drug for treatment of tinnitus patients
PH12016502113A1 (en) Drug for treatment of tinnitus patients
GEP20196945B (en) (r)-pirlindole and its pharmaceutically acceptable salts for use in medicine
GEP20196946B (en) (s)-pirlindole or its pharmaceutically acceptable salts for use in medicine