MX2019015156A - Dispositivo de control y sensor de poro dual. - Google Patents

Dispositivo de control y sensor de poro dual.

Info

Publication number
MX2019015156A
MX2019015156A MX2019015156A MX2019015156A MX2019015156A MX 2019015156 A MX2019015156 A MX 2019015156A MX 2019015156 A MX2019015156 A MX 2019015156A MX 2019015156 A MX2019015156 A MX 2019015156A MX 2019015156 A MX2019015156 A MX 2019015156A
Authority
MX
Mexico
Prior art keywords
chamber
nanopore
target
control
sensing
Prior art date
Application number
MX2019015156A
Other languages
English (en)
Inventor
William B Dunbar
Reto Stamm
Michael Summers
Eric Thorne
Original Assignee
Ontera Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ontera Inc filed Critical Ontera Inc
Publication of MX2019015156A publication Critical patent/MX2019015156A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48721—Investigating individual macromolecules, e.g. by translocation through nanopores
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G01N27/44791—Microapparatus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44743—Introducing samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Electrochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Nanotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Se describen dispositivos de dos poros y método para secuenciación. Un dispositivo de dos poros puede incluir una primera cámara, una segunda cámara, y una tercera cámara, en donde la primera cámara está en comunicación con la segunda cámara a través de un primer nanoporo, y en donde la segunda cámara está en comunicación con la tercera cámara a través de un segundo nanoporo. El dispositivo también puede incluir circuitería de detección para medir señales eléctricas asociadas con un objetivo en un nanoporo, y circuitería de control para controlar el movimiento del objetivo en un nanoporo. El dispositivo puede incluir y/o cambiar entre modos de detección y control para cada uno del primer nanoporo y el segundo nanoporo. Los métodos de secuenciación pueden implementar un dispositivo de dos poros con relación a la translocación de un objetivo a través de uno o más nanoporos, cambiar entre modos de detección y control según sea apropiado, y medir aspectos del objetivo utilizando modos de detección.
MX2019015156A 2017-06-21 2018-06-14 Dispositivo de control y sensor de poro dual. MX2019015156A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762523228P 2017-06-21 2017-06-21
PCT/US2018/037634 WO2018236673A1 (en) 2017-06-21 2018-06-14 DOUBLE PORE DETECTION AND CONTROL DEVICE

Publications (1)

Publication Number Publication Date
MX2019015156A true MX2019015156A (es) 2020-08-17

Family

ID=64692458

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019015156A MX2019015156A (es) 2017-06-21 2018-06-14 Dispositivo de control y sensor de poro dual.

Country Status (8)

Country Link
US (2) US11099169B2 (es)
EP (1) EP3642607A4 (es)
JP (2) JP7038147B2 (es)
KR (2) KR102377508B1 (es)
CN (1) CN111065917A (es)
CA (1) CA3067993C (es)
MX (1) MX2019015156A (es)
WO (1) WO2018236673A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201202519D0 (en) 2012-02-13 2012-03-28 Oxford Nanopore Tech Ltd Apparatus for supporting an array of layers of amphiphilic molecules and method of forming an array of layers of amphiphilic molecules
KR102377508B1 (ko) * 2017-06-21 2022-03-23 온테라 인크. 듀얼 포어－제어 및 감지 장치
CN113574381A (zh) 2019-03-12 2021-10-29 牛津纳米孔科技公司 纳米孔感测装置、组件和操作方法
JP7250962B2 (ja) * 2019-06-07 2023-04-03 アプライド マテリアルズ インコーポレイテッド デュアルポアセンサの製造方法
EP4010492A4 (en) * 2019-08-06 2024-04-03 Nooma Bio, Inc. LOGIC-CONTROLLED POLYNUCLEOTIDE SCANNING FOR FEATURE IMAGING IN A NANOPORE DEVICE
CN112708544A (zh) * 2019-10-25 2021-04-27 成都今是科技有限公司 基因测序的测量装置及其测量方法
CN110823773A (zh) * 2019-11-22 2020-02-21 瑞芯智造(深圳)科技有限公司 用于测量微纳颗粒的装置及方法
US11536708B2 (en) 2020-01-09 2022-12-27 Applied Materials, Inc. Methods to fabricate dual pore devices
KR20230038566A (ko) * 2020-07-17 2023-03-20 옥스포드 나노포어 테크놀로지즈 피엘씨 나노포어 감지 디바이스
EP4314812A1 (en) * 2021-03-31 2024-02-07 Illumina, Inc. Scalable circuit for molecular detection

Family Cites Families (16)

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Publication number Priority date Publication date Assignee Title
US6740518B1 (en) * 1998-09-17 2004-05-25 Clinical Micro Sensors, Inc. Signal detection techniques for the detection of analytes
US7250115B2 (en) * 2003-06-12 2007-07-31 Agilent Technologies, Inc Nanopore with resonant tunneling electrodes
DE602006016813D1 (de) * 2006-10-13 2010-10-21 Univ Sabanci Biosensor- und chemische Sensorimplementierung unter Verwendung von Hochfrequenz und einer Mikrowellenvorrichtung, Schaltkreisen und Systemen
US8294092B2 (en) * 2009-03-23 2012-10-23 Yale University System and method for trapping and measuring a charged particle in a liquid
ES2659343T3 (es) 2011-07-20 2018-03-14 The Regents Of The University Of California Dispositivo de poro dual
EP2734839B1 (en) * 2011-07-20 2017-11-08 The Regents of The University of California Compensated patch-clamp amplifier for nanopore polynucleotide sequencing
JP6298404B2 (ja) 2011-07-25 2018-03-20 オックスフォード ナノポール テクノロジーズ リミテッド 膜貫通ポアを用いる二重鎖ポリヌクレオチド配列決定のためのヘアピンループ方法
CA2855824C (en) 2011-11-14 2021-07-20 The Regents Of The University Of California Device for polymer sequencing through a nanopore by measuring iconic current and methods thereof
US20140099726A1 (en) * 2012-10-10 2014-04-10 Two Pore Guys, Inc. Device for characterizing polymers
JP2016512605A (ja) * 2013-03-13 2016-04-28 アリゾナ ボード オブ リージェンツ オン ビハーフ オブ アリゾナ ステート ユニバーシティ 転位制御のためのシステム、デバイス、および方法
EP2994751B1 (en) * 2013-05-06 2018-10-10 Two Pore Guys, Inc. A method of biological target detection using a nanopore and a fusion protein binding agent
KR102245192B1 (ko) * 2013-05-06 2021-04-29 온테라 인크. 나노포어를 이용한 표적 검출
EP3274293A4 (en) * 2015-03-23 2018-08-22 The University of North Carolina at Chapel Hill Method for identification and enumeration of nucleic acid sequences, expression, splice variant, translocation, copy, or dna methylation changes using combined nuclease, ligase, polymerase, terminal transferase, and sequencing reactions
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Also Published As

Publication number Publication date
KR20210129726A (ko) 2021-10-28
JP7038147B2 (ja) 2022-03-17
EP3642607A1 (en) 2020-04-29
CA3067993A1 (en) 2018-12-27
KR20200042894A (ko) 2020-04-24
EP3642607A4 (en) 2021-04-14
US20180372713A1 (en) 2018-12-27
WO2018236673A1 (en) 2018-12-27
KR102377508B1 (ko) 2022-03-23
US20210405020A1 (en) 2021-12-30
JP2020524801A (ja) 2020-08-20
CA3067993C (en) 2024-02-27
JP2022088415A (ja) 2022-06-14
US11099169B2 (en) 2021-08-24
CN111065917A (zh) 2020-04-24
KR102315815B1 (ko) 2021-10-25

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